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char = l;code = 108
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char = d;code = 100
char = ;code = 32
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char = n;code = 110
char = ;code = 32
char = v;code = 118
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char = e;code = 101
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = e;code = 101
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char = l;code = 108
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char = t;code = 116
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char = m;code = 109
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
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char = m;code = 109
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = l;code = 108
char = d;code = 100
char = .;code = 46
result sql = Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold.
Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold.
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char = R;code = 82
char = O;code = 79
char = U;code = 85
char = N;code = 78
char = D;code = 68
char = ;code = 32
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char = ;code = 32
char = <;code = 60
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char = m;code = 109
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
char = t;code = 116
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char = r;code = 114
char = y;code = 121
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char = m;code = 109
char = e;code = 101
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char = i;code = 105
char = a;code = 97
char = t;code = 116
char = o;code = 111
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char = F;code = 70
char = G;code = 71
char = F;code = 70
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char = ;code = 32
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char = F;code = 70
char = ,;code = 44
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char = 8;code = 56
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char = ;code = 32
char = I;code = 73
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char = ,;code = 44
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char = I;code = 73
char = L;code = 76
char = -;code = 45
char = 1;code = 49
char = 0;code = 48
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
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char = ;code = 32
char = I;code = 73
char = F;code = 70
char = N;code = 78
char = -;code = 45
char = a;code = 97
char = l;code = 108
char = p;code = 112
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char = a;code = 97
char = 2;code = 50
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = r;code = 114
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char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = I;code = 73
char = o;code = 111
char = t;code = 116
char = a;code = 97
char = -;code = 45
char = C;code = 67
char = a;code = 97
char = r;code = 114
char = r;code = 114
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = e;code = 101
char = n;code = 110
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = C;code = 67
char = O;code = 79
char = N;code = 78
char = C;code = 67
char = L;code = 76
char = U;code = 85
char = S;code = 83
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = I;code = 73
char = o;code = 111
char = t;code = 116
char = a;code = 97
char = -;code = 45
char = C;code = 67
char = a;code = 97
char = r;code = 114
char = r;code = 114
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = e;code = 101
char = n;code = 110
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = n;code = 110
char = a;code = 97
char = s;code = 115
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = s;code = 115
char = p;code = 112
char = r;code = 114
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = i;code = 105
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
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char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
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char = o;code = 111
char = r;code = 114
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char = f;code = 102
char = e;code = 101
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char = ;code = 32
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char = f;code = 102
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char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
char = n;code = 110
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char = ;code = 32
char = e;code = 101
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char = r;code = 114
char = l;code = 108
char = y;code = 121
char = ;code = 32
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char = y;code = 121
char = m;code = 109
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = m;code = 109
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = l;code = 108
char = d;code = 100
char = .;code = 46
char = ;code = 32
char = L;code = 76
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = f;code = 102
char = i;code = 105
char = r;code = 114
char = m;code = 109
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = s;code = 115
char = .;code = 46
result sql = BACKGROUND : The common cold, the most prevalent contagious viral disease in humans still lacks a safe and effective antiviral treatment. Iota-Carrageenan is broadly active against respiratory viruses in-vitro and has an excellent safety profile. This study investigated the efficacy and safety of an Iota-Carrageenan nasal spray in patients with common cold symptoms.

METHODS : In a randomized, double-blind, placebo-controlled exploratory trial, 35 human subjects suffering from early symptoms of common cold received Iota-Carrageenan (0.12%) in a saline solution three times daily for 4 days, compared to placebo.

RESULTS : Administration of Iota-Carrageenan nasal spray reduced the symptoms of common cold (p = 0.046) and the viral load in nasal lavages (p = 0.009) in patients with early symptoms of common cold. Pro-inflammatory mediators FGF-2, Fractalkine, GRO, G-CSF, IL-8, IL-1alpha, IP-10, IL-10, and IFN-alpha2 were reduced in the Iota-Carrageenan group.

CONCLUSIONS : Iota-Carrageenan nasal spray appears to be a promising treatment for safe and effective treatment of early symptoms of common cold. Larger trials are indicated to confirm the results.

Publication: Respir. Res. 2010 ;11:108. :doi: 10.1186/1465-9921-11-108.
Publication Date: 2010
Study Author(s): Eccles, Ron;Meier, Christiane;Jawad, Martez;Weinmüllner, Regina;Grassauer, Andreas;Prieschl-Grassauer, Eva;
Institution: Marinomed Biotechnologie GmbH, Veterinaerplatz 1, Vienna, Austria.
Shortcut link to this study:
BACKGROUND : The common cold, the most prevalent contagious viral disease in humans still lacks a safe and effective antiviral treatment. Iota-Carrageenan is broadly active against respiratory viruses in-vitro and has an excellent safety profile. This study investigated the efficacy and safety of an Iota-Carrageenan nasal spray in patients with common cold symptoms.

METHODS : In a randomized, double-blind, placebo-controlled exploratory trial, 35 human subjects suffering from early symptoms of common cold received Iota-Carrageenan (0.12%) in a saline solution three times daily for 4 days, compared to placebo.

RESULTS : Administration of Iota-Carrageenan nasal spray reduced the symptoms of common cold (p = 0.046) and the viral load in nasal lavages (p = 0.009) in patients with early symptoms of common cold. Pro-inflammatory mediators FGF-2, Fractalkine, GRO, G-CSF, IL-8, IL-1alpha, IP-10, IL-10, and IFN-alpha2 were reduced in the Iota-Carrageenan group.

CONCLUSIONS : Iota-Carrageenan nasal spray appears to be a promising treatment for safe and effective treatment of early symptoms of common cold. Larger trials are indicated to confirm the results.
PMID: 20696083

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