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result sql = Association between thyroid hormones, lipids and oxidative stress biomarkers in overt hypothyroidism.
Association between thyroid hormones, lipids and oxidative stress biomarkers in overt hypothyroidism.char = <;code = 60
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result sql = BACKGROUND : The aim of this study was to investigate the effect of hypothyroidism on lipid peroxidation and the antioxidant profile, as well as to evaluate the interaction between thyroid hormones and biomarkers of oxidative stress in patients with overt hypothyroidism. We also evaluated the influence of cholesterol concentrations on biomarkers of oxidative stress in these same patients.
METHODS : Total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and vitamin E were measured in 20 subjects with overt hypothyroidism (OH) and 20 controls.
RESULTS : TC, LDL cholesterol, triglycerides, TBARS, SOD, CAT, and vitamin E were significantly higher in the OH group. Significant correlation was observed for TSH and SOD, CAT, vitamin E and TBARS. Correlation was observed for triiodothyronine (T3) and SOD, CAT, vitamin E and TBARS. Significant correlation was also observed for free thyroxine and vitamin E and TBARS. However, correlation between T3 and CAT remained significant after controlling for TC concentrations.
CONCLUSIONS : Overt hypothyroidism is associated with an increase in oxidative stress, and hypercholesterolemia has a stronger influence on development of oxidative stress in hypothyroid conditions compared with thyroid hormones.
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result sql = Association between thyroid hormones, lipids and oxidative stress biomarkers in overt hypothyroidism.
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char = l;code = 108
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char = a;code = 97
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char = ;code = 32
char = t;code = 116
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char = a;code = 97
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char = u;code = 117
char = a;code = 97
char = t;code = 116
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = i;code = 105
char = n;code = 110
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char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
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char = o;code = 111
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char = b;code = 98
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char = t;code = 116
char = w;code = 119
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char = e;code = 101
char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = y;code = 121
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char = i;code = 105
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char = r;code = 114
char = m;code = 109
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char = e;code = 101
char = s;code = 115
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char = a;code = 97
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char = a;code = 97
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char = k;code = 107
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char = r;code = 114
char = s;code = 115
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char = f;code = 102
char = ;code = 32
char = o;code = 111
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char = d;code = 100
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
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char = s;code = 115
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
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char = i;code = 105
char = n;code = 110
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char = p;code = 112
char = a;code = 97
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char = e;code = 101
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char = t;code = 116
char = s;code = 115
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = e;code = 101
char = r;code = 114
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char = h;code = 104
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char = p;code = 112
char = o;code = 111
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char = h;code = 104
char = y;code = 121
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char = o;code = 111
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char = d;code = 100
char = i;code = 105
char = s;code = 115
char = m;code = 109
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char = ;code = 32
char = W;code = 87
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char = ;code = 32
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
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char = e;code = 101
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char = a;code = 97
char = l;code = 108
char = u;code = 117
char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
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char = e;code = 101
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char = i;code = 105
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char = f;code = 102
char = l;code = 108
char = u;code = 117
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char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = o;code = 111
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char = e;code = 101
char = s;code = 115
char = t;code = 116
char = e;code = 101
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char = o;code = 111
char = l;code = 108
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char = c;code = 99
char = o;code = 111
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
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char = o;code = 111
char = n;code = 110
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char = b;code = 98
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char = o;code = 111
char = m;code = 109
char = a;code = 97
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char = k;code = 107
char = e;code = 101
char = r;code = 114
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = o;code = 111
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char = i;code = 105
char = d;code = 100
char = a;code = 97
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char = v;code = 118
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char = t;code = 116
char = r;code = 114
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char = s;code = 115
char = s;code = 115
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char = i;code = 105
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char = t;code = 116
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char = s;code = 115
char = e;code = 101
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char = s;code = 115
char = a;code = 97
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char = e;code = 101
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char = p;code = 112
char = a;code = 97
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char = i;code = 105
char = e;code = 101
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char = t;code = 116
char = s;code = 115
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char = <;code = 60
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char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = M;code = 77
char = E;code = 69
char = T;code = 84
char = H;code = 72
char = O;code = 79
char = D;code = 68
char = S;code = 83
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char = :;code = 58
char = ;code = 32
char = <;code = 60
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char = b;code = 98
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char = o;code = 111
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char = a;code = 97
char = l;code = 108
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char = e;code = 101
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char = l;code = 108
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char = T;code = 84
char = C;code = 67
char = );code = 41
char = ,;code = 44
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char = h;code = 104
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char = h;code = 104
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char = t;code = 116
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char = o;code = 111
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char = H;code = 72
char = D;code = 68
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char = ;code = 32
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char = e;code = 101
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char = t;code = 116
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char = r;code = 114
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char = l;code = 108
char = ,;code = 44
char = ;code = 32
char = l;code = 108
char = o;code = 111
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char = d;code = 100
char = e;code = 101
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char = s;code = 115
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char = t;code = 116
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char = L;code = 76
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char = T;code = 84
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char = A;code = 65
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char = ,;code = 44
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char = O;code = 79
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char = ,;code = 44
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char = C;code = 67
char = A;code = 65
char = T;code = 84
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char = E;code = 69
char = ;code = 32
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char = O;code = 79
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char = ;code = 32
char = a;code = 97
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char = c;code = 99
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char = n;code = 110
char = t;code = 116
char = r;code = 114
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char = l;code = 108
char = s;code = 115
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char = >;code = 62
char = <;code = 60
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char = r;code = 114
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char = <;code = 60
char = b;code = 98
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char = R;code = 82
char = E;code = 69
char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
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char = >;code = 62
char = T;code = 84
char = C;code = 67
char = ,;code = 44
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char = L;code = 76
char = D;code = 68
char = L;code = 76
char = ;code = 32
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char = A;code = 65
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char = S;code = 83
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char = S;code = 83
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char = H;code = 72
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char = g;code = 103
char = r;code = 114
char = o;code = 111
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char = T;code = 84
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char = H;code = 72
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char = C;code = 67
char = A;code = 65
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char = T;code = 84
char = B;code = 66
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char = S;code = 83
char = .;code = 46
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char = S;code = 83
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char = C;code = 67
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char = E;code = 69
char = ;code = 32
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char = T;code = 84
char = B;code = 66
char = A;code = 65
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char = S;code = 83
char = .;code = 46
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char = r;code = 114
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char = l;code = 108
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result sql = BACKGROUND : The aim of this study was to investigate the effect of hypothyroidism on lipid peroxidation and the antioxidant profile, as well as to evaluate the interaction between thyroid hormones and biomarkers of oxidative stress in patients with overt hypothyroidism. We also evaluated the influence of cholesterol concentrations on biomarkers of oxidative stress in these same patients.
METHODS : Total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and vitamin E were measured in 20 subjects with overt hypothyroidism (OH) and 20 controls.
RESULTS : TC, LDL cholesterol, triglycerides, TBARS, SOD, CAT, and vitamin E were significantly higher in the OH group. Significant correlation was observed for TSH and SOD, CAT, vitamin E and TBARS. Correlation was observed for triiodothyronine (T3) and SOD, CAT, vitamin E and TBARS. Significant correlation was also observed for free thyroxine and vitamin E and TBARS. However, correlation between T3 and CAT remained significant after controlling for TC concentrations.
CONCLUSIONS : Overt hypothyroidism is associated with an increase in oxidative stress, and hypercholesterolemia has a stronger influence on development of oxidative stress in hypothyroid conditions compared with thyroid hormones.
Publication: Clin. Chem. Lab. Med. 2010 Nov ;48(11)::1635-9. :doi: 10.1515/CCLM.2010.309.
Publication Date: 2010 Nov
Study Author(s): Santi, Adriana;Duarte, Marta Maria Medeiros Frescura;Moresco, Rafael Noal;Menezes, Charlene;Bagatini, Margarete Dulce;Schetinger, Maria Rosa Chitolina;Loro, Vania Lucia;
Institution: Departamento de Fisiologia e Farmacologia, Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, RS, Brazil.
Shortcut link to this study:
Publication Date: 2010 Nov
Study Author(s): Santi, Adriana;Duarte, Marta Maria Medeiros Frescura;Moresco, Rafael Noal;Menezes, Charlene;Bagatini, Margarete Dulce;Schetinger, Maria Rosa Chitolina;Loro, Vania Lucia;
Institution: Departamento de Fisiologia e Farmacologia, Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, RS, Brazil.
Shortcut link to this study:
BACKGROUND : The aim of this study was to investigate the effect of hypothyroidism on lipid peroxidation and the antioxidant profile, as well as to evaluate the interaction between thyroid hormones and biomarkers of oxidative stress in patients with overt hypothyroidism. We also evaluated the influence of cholesterol concentrations on biomarkers of oxidative stress in these same patients.
METHODS : Total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and vitamin E were measured in 20 subjects with overt hypothyroidism (OH) and 20 controls.
RESULTS : TC, LDL cholesterol, triglycerides, TBARS, SOD, CAT, and vitamin E were significantly higher in the OH group. Significant correlation was observed for TSH and SOD, CAT, vitamin E and TBARS. Correlation was observed for triiodothyronine (T3) and SOD, CAT, vitamin E and TBARS. Significant correlation was also observed for free thyroxine and vitamin E and TBARS. However, correlation between T3 and CAT remained significant after controlling for TC concentrations.
CONCLUSIONS : Overt hypothyroidism is associated with an increase in oxidative stress, and hypercholesterolemia has a stronger influence on development of oxidative stress in hypothyroid conditions compared with thyroid hormones.
METHODS : Total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and vitamin E were measured in 20 subjects with overt hypothyroidism (OH) and 20 controls.
RESULTS : TC, LDL cholesterol, triglycerides, TBARS, SOD, CAT, and vitamin E were significantly higher in the OH group. Significant correlation was observed for TSH and SOD, CAT, vitamin E and TBARS. Correlation was observed for triiodothyronine (T3) and SOD, CAT, vitamin E and TBARS. Significant correlation was also observed for free thyroxine and vitamin E and TBARS. However, correlation between T3 and CAT remained significant after controlling for TC concentrations.
CONCLUSIONS : Overt hypothyroidism is associated with an increase in oxidative stress, and hypercholesterolemia has a stronger influence on development of oxidative stress in hypothyroid conditions compared with thyroid hormones.
PMID: 20704527
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