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char = e;code = 101
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char = m;code = 109
char = a;code = 97
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char = t;code = 116
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char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = ;code = 32
char = T;code = 84
char = N;code = 78
char = F;code = 70
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char = a;code = 97
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char = p;code = 112
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char = a;code = 97
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char = s;code = 115
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char = e;code = 101
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char = m;code = 109
char = a;code = 97
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char = r;code = 114
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char = K;code = 75
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char = a;code = 97
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char = P;code = 80
char = ;code = 32
char = <;code = 60
char = ;code = 32
char = .;code = 46
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char = a;code = 97
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char = I;code = 73
char = K;code = 75
char = K;code = 75
char = -;code = 45
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = a;code = 97
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char = 7;code = 55
char = 3;code = 51
char = %;code = 37
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char = P;code = 80
char = ;code = 32
char = <;code = 60
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char = .;code = 46
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char = ;code = 32
char = p;code = 112
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char = o;code = 111
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char = o;code = 111
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char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = T;code = 84
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = I;code = 73
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char = m;code = 109
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char = s;code = 115
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char = e;code = 101
char = r;code = 114
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char = R;code = 82
char = N;code = 78
char = A;code = 65
char = ;code = 32
char = (;code = 40
char = m;code = 109
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char = N;code = 78
char = A;code = 65
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char = ;code = 32
char = (;code = 40
char = ;code = 32
char = a;code = 97
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char = p;code = 112
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char = a;code = 97
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char = %;code = 37
char = ,;code = 44
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char = P;code = 80
char = ;code = 32
char = <;code = 60
char = ;code = 32
char = .;code = 46
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char = e;code = 101
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char = a;code = 97
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char = e;code = 101
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char = G;code = 71
char = L;code = 76
char = U;code = 85
char = T;code = 84
char = 4;code = 52
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char = m;code = 109
char = R;code = 82
char = N;code = 78
char = A;code = 65
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
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char = %;code = 37
char = ,;code = 44
char = ;code = 32
char = P;code = 80
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char = ;code = 32
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char = l;code = 108
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char = ;code = 32
char = T;code = 84
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = a;code = 97
char = l;code = 108
char = p;code = 112
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char = a;code = 97
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char = I;code = 73
char = L;code = 76
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char = 6;code = 54
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char = p;code = 112
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char = a;code = 97
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char = i;code = 105
char = z;code = 122
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char = I;code = 73
char = K;code = 75
char = K;code = 75
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char = i;code = 105
char = o;code = 111
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char = T;code = 84
char = N;code = 78
char = F;code = 70
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char = a;code = 97
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char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = I;code = 73
char = L;code = 76
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char = 6;code = 54
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char = U;code = 85
char = T;code = 84
char = 4;code = 52
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char = m;code = 109
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char = N;code = 78
char = A;code = 65
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char = a;code = 97
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char = f;code = 102
char = f;code = 102
char = e;code = 101
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result sql = Considering that inflammation contributes to obesity-induced insulin resistance and that statins have been reported to have other effects beyond cholesterol lowering, the present study aimed to investigate whether atorvastatin treatment has anti-inflammatory action in white adipose tissue of obese mice, consequently improving insulin sensitivity. Insulin sensitivity in vivo (by insulin tolerance test); metabolic-hormonal profile; plasma tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and adiponectin; adipose tissue immunohistochemistry; glucose transporter (GLUT) 4; adiponectin; TNF-alpha; IL-1 beta; and IL-6 gene expression; and I kappaB kinase (IKK)-alpha/beta activity were assessed in 23-week-old monosodium glutamate-induced obese mice untreated or treated with atorvastatin for 4 weeks. Insulin-resistant obese mice had increased plasma triglyceride, insulin, TNF-alpha, and IL-6 plasma levels. Adipose tissue of obese animals showed increased macrophage infiltration, IKK-alpha (42%, P < .05) and IKK-beta (73%, P < .05) phosphorylation, and TNF-alpha and IL-6 messenger RNA (mRNA) ( approximately 15%, P < .05) levels, and decreased GLUT4 mRNA and protein (30%, P < .05) levels. Atorvastatin treatment lowered cholesterol, triglyceride, insulin, TNF-alpha, and IL-6 plasma levels, and restored whole-body insulin sensitivity. In adipose tissue, atorvastatin decreased macrophage infiltration and normalized IKK-alpha/beta phosphorylation; TNF-alpha, IL-6, and GLUT4 mRNA; and GLUT4 protein to control levels. The present findings demonstrate that atorvastatin has anti-inflammatory effects on adipose tissue of obese mice, which may be important to its local and whole-body insulin-sensitization effects.
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result sql = Anti-inflammatory effect of atorvastatin ameliorates insulin resistance in monosodium glutamate-treated obese mice.
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char = e;code = 101
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char = t;code = 116
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char = a;code = 97
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char = e;code = 101
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char = a;code = 97
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char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = n;code = 110
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char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = 4;code = 52
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = e;code = 101
char = k;code = 107
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char = s;code = 115
char = u;code = 117
char = l;code = 108
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char = n;code = 110
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char = i;code = 105
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = n;code = 110
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char = o;code = 111
char = b;code = 98
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = m;code = 109
char = i;code = 105
char = c;code = 99
char = e;code = 101
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char = h;code = 104
char = a;code = 97
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
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char = a;code = 97
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char = e;code = 101
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char = ;code = 32
char = p;code = 112
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char = a;code = 97
char = s;code = 115
char = m;code = 109
char = a;code = 97
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char = t;code = 116
char = r;code = 114
char = i;code = 105
char = g;code = 103
char = l;code = 108
char = y;code = 121
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char = e;code = 101
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char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = ;code = 32
char = T;code = 84
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = ,;code = 44
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = I;code = 73
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char = -;code = 45
char = 6;code = 54
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char = p;code = 112
char = l;code = 108
char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = l;code = 108
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = d;code = 100
char = i;code = 105
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = s;code = 115
char = s;code = 115
char = u;code = 117
char = e;code = 101
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char = o;code = 111
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char = ;code = 32
char = o;code = 111
char = b;code = 98
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
char = l;code = 108
char = s;code = 115
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char = s;code = 115
char = h;code = 104
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = c;code = 99
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = g;code = 103
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = f;code = 102
char = i;code = 105
char = l;code = 108
char = t;code = 116
char = r;code = 114
char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = I;code = 73
char = K;code = 75
char = K;code = 75
char = -;code = 45
char = a;code = 97
char = l;code = 108
char = p;code = 112
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char = a;code = 97
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char = 4;code = 52
char = 2;code = 50
char = %;code = 37
char = ,;code = 44
char = ;code = 32
char = P;code = 80
char = ;code = 32
char = <;code = 60
char = ;code = 32
char = .;code = 46
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char = 5;code = 53
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = I;code = 73
char = K;code = 75
char = K;code = 75
char = -;code = 45
char = b;code = 98
char = e;code = 101
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char = a;code = 97
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char = (;code = 40
char = 7;code = 55
char = 3;code = 51
char = %;code = 37
char = ,;code = 44
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char = P;code = 80
char = ;code = 32
char = <;code = 60
char = ;code = 32
char = .;code = 46
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char = 5;code = 53
char = );code = 41
char = ;code = 32
char = p;code = 112
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char = o;code = 111
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char = p;code = 112
char = h;code = 104
char = o;code = 111
char = r;code = 114
char = y;code = 121
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char = i;code = 105
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char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = T;code = 84
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = a;code = 97
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char = d;code = 100
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char = I;code = 73
char = L;code = 76
char = -;code = 45
char = 6;code = 54
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char = m;code = 109
char = e;code = 101
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char = s;code = 115
char = e;code = 101
char = n;code = 110
char = g;code = 103
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = R;code = 82
char = N;code = 78
char = A;code = 65
char = ;code = 32
char = (;code = 40
char = m;code = 109
char = R;code = 82
char = N;code = 78
char = A;code = 65
char = );code = 41
char = ;code = 32
char = (;code = 40
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = r;code = 114
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char = x;code = 120
char = i;code = 105
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = l;code = 108
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char = 1;code = 49
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char = %;code = 37
char = ,;code = 44
char = ;code = 32
char = P;code = 80
char = ;code = 32
char = <;code = 60
char = ;code = 32
char = .;code = 46
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char = 5;code = 53
char = );code = 41
char = ;code = 32
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char = v;code = 118
char = e;code = 101
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char = d;code = 100
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char = d;code = 100
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char = c;code = 99
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = G;code = 71
char = L;code = 76
char = U;code = 85
char = T;code = 84
char = 4;code = 52
char = ;code = 32
char = m;code = 109
char = R;code = 82
char = N;code = 78
char = A;code = 65
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = 3;code = 51
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char = %;code = 37
char = ,;code = 44
char = ;code = 32
char = P;code = 80
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char = .;code = 46
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char = 5;code = 53
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char = v;code = 118
char = e;code = 101
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char = a;code = 97
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char = a;code = 97
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char = a;code = 97
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char = m;code = 109
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char = e;code = 101
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char = c;code = 99
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char = l;code = 108
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char = t;code = 116
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char = g;code = 103
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char = u;code = 117
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = T;code = 84
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = I;code = 73
char = L;code = 76
char = -;code = 45
char = 6;code = 54
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char = p;code = 112
char = l;code = 108
char = a;code = 97
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char = e;code = 101
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char = b;code = 98
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char = y;code = 121
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char = u;code = 117
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char = e;code = 101
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char = s;code = 115
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char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
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char = a;code = 97
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char = i;code = 105
char = p;code = 112
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char = s;code = 115
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char = i;code = 105
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char = s;code = 115
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char = e;code = 101
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char = ;code = 32
char = a;code = 97
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char = o;code = 111
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char = a;code = 97
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char = a;code = 97
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char = i;code = 105
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char = c;code = 99
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char = e;code = 101
char = d;code = 100
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char = m;code = 109
char = a;code = 97
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char = p;code = 112
char = h;code = 104
char = a;code = 97
char = g;code = 103
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char = i;code = 105
char = l;code = 108
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char = i;code = 105
char = z;code = 122
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char = d;code = 100
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char = I;code = 73
char = K;code = 75
char = K;code = 75
char = -;code = 45
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char = p;code = 112
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char = b;code = 98
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char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = T;code = 84
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = a;code = 97
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char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = I;code = 73
char = L;code = 76
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char = 6;code = 54
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = G;code = 71
char = L;code = 76
char = U;code = 85
char = T;code = 84
char = 4;code = 52
char = ;code = 32
char = m;code = 109
char = R;code = 82
char = N;code = 78
char = A;code = 65
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = G;code = 71
char = L;code = 76
char = U;code = 85
char = T;code = 84
char = 4;code = 52
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char = p;code = 112
char = r;code = 114
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char = t;code = 116
char = e;code = 101
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char = e;code = 101
char = v;code = 118
char = e;code = 101
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char = s;code = 115
char = .;code = 46
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char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = p;code = 112
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char = i;code = 105
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char = i;code = 105
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char = l;code = 108
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char = a;code = 97
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char = o;code = 111
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char = y;code = 121
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char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = p;code = 112
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char = s;code = 115
char = s;code = 115
char = u;code = 117
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = o;code = 111
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char = e;code = 101
char = s;code = 115
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char = m;code = 109
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char = c;code = 99
char = e;code = 101
char = ,;code = 44
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char = w;code = 119
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char = i;code = 105
char = c;code = 99
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char = m;code = 109
char = a;code = 97
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char = b;code = 98
char = e;code = 101
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char = i;code = 105
char = m;code = 109
char = p;code = 112
char = o;code = 111
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char = a;code = 97
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char = t;code = 116
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char = t;code = 116
char = o;code = 111
char = ;code = 32
char = i;code = 105
char = t;code = 116
char = s;code = 115
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char = l;code = 108
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result sql = Considering that inflammation contributes to obesity-induced insulin resistance and that statins have been reported to have other effects beyond cholesterol lowering, the present study aimed to investigate whether atorvastatin treatment has anti-inflammatory action in white adipose tissue of obese mice, consequently improving insulin sensitivity. Insulin sensitivity in vivo (by insulin tolerance test); metabolic-hormonal profile; plasma tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and adiponectin; adipose tissue immunohistochemistry; glucose transporter (GLUT) 4; adiponectin; TNF-alpha; IL-1 beta; and IL-6 gene expression; and I kappaB kinase (IKK)-alpha/beta activity were assessed in 23-week-old monosodium glutamate-induced obese mice untreated or treated with atorvastatin for 4 weeks. Insulin-resistant obese mice had increased plasma triglyceride, insulin, TNF-alpha, and IL-6 plasma levels. Adipose tissue of obese animals showed increased macrophage infiltration, IKK-alpha (42%, P < .05) and IKK-beta (73%, P < .05) phosphorylation, and TNF-alpha and IL-6 messenger RNA (mRNA) ( approximately 15%, P < .05) levels, and decreased GLUT4 mRNA and protein (30%, P < .05) levels. Atorvastatin treatment lowered cholesterol, triglyceride, insulin, TNF-alpha, and IL-6 plasma levels, and restored whole-body insulin sensitivity. In adipose tissue, atorvastatin decreased macrophage infiltration and normalized IKK-alpha/beta phosphorylation; TNF-alpha, IL-6, and GLUT4 mRNA; and GLUT4 protein to control levels. The present findings demonstrate that atorvastatin has anti-inflammatory effects on adipose tissue of obese mice, which may be important to its local and whole-body insulin-sensitization effects.
Publication: Metab. Clin. Exp. 2010 Mar ;59(3)::395-9. :doi: 10.1016/j.metabol.2009.08.011.
Publication Date: 2010 Mar
Study Author(s): Furuya, Daniela T;Poletto, Ana C;Favaro, Rodolfo R;Martins, Joilson O;Zorn, Telma M T;Machado, Ubiratan F;
Institution: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, Brasil. [email protected]
Shortcut link to this study:
Publication Date: 2010 Mar
Study Author(s): Furuya, Daniela T;Poletto, Ana C;Favaro, Rodolfo R;Martins, Joilson O;Zorn, Telma M T;Machado, Ubiratan F;
Institution: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, Brasil. [email protected]
Shortcut link to this study:
Considering that inflammation contributes to obesity-induced insulin resistance and that statins have been reported to have other effects beyond cholesterol lowering, the present study aimed to investigate whether atorvastatin treatment has anti-inflammatory action in white adipose tissue of obese mice, consequently improving insulin sensitivity. Insulin sensitivity in vivo (by insulin tolerance test); metabolic-hormonal profile; plasma tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and adiponectin; adipose tissue immunohistochemistry; glucose transporter (GLUT) 4; adiponectin; TNF-alpha; IL-1 beta; and IL-6 gene expression; and I kappaB kinase (IKK)-alpha/beta activity were assessed in 23-week-old monosodium glutamate-induced obese mice untreated or treated with atorvastatin for 4 weeks. Insulin-resistant obese mice had increased plasma triglyceride, insulin, TNF-alpha, and IL-6 plasma levels. Adipose tissue of obese animals showed increased macrophage infiltration, IKK-alpha (42%, P < .05) and IKK-beta (73%, P < .05) phosphorylation, and TNF-alpha and IL-6 messenger RNA (mRNA) ( approximately 15%, P < .05) levels, and decreased GLUT4 mRNA and protein (30%, P < .05) levels. Atorvastatin treatment lowered cholesterol, triglyceride, insulin, TNF-alpha, and IL-6 plasma levels, and restored whole-body insulin sensitivity. In adipose tissue, atorvastatin decreased macrophage infiltration and normalized IKK-alpha/beta phosphorylation; TNF-alpha, IL-6, and GLUT4 mRNA; and GLUT4 protein to control levels. The present findings demonstrate that atorvastatin has anti-inflammatory effects on adipose tissue of obese mice, which may be important to its local and whole-body insulin-sensitization effects.
PMID: 19800637
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