|
|
char = P;code = 80
char = b;code = 98
char = 2;code = 50
char = +;code = 43
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char = ;code = 32
char = e;code = 101
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char = o;code = 111
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char = o;code = 111
char = p;code = 112
char = h;code = 104
char = i;code = 105
char = l;code = 108
char = a;code = 97
char = ?;code = 63
result sql = Pb2+: an endocrine disruptor in Drosophila?
Pb2+: an endocrine disruptor in Drosophila?char = E;code = 69
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char = v;code = 118
char = i;code = 105
char = r;code = 114
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char = n;code = 110
char = m;code = 109
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char = p;code = 112
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char = u;code = 117
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char = e;code = 101
char = ;code = 32
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char = o;code = 111
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char = P;code = 80
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char = (;code = 40
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char = );code = 41
char = ;code = 32
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char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = s;code = 115
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char = h;code = 104
char = o;code = 111
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char = m;code = 109
char = o;code = 111
char = n;code = 110
char = e;code = 101
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char = d;code = 100
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char = d;code = 100
char = ;code = 32
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char = s;code = 115
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char = ;code = 32
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char = e;code = 101
char = b;code = 98
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
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char = r;code = 114
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char = ;code = 32
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char = y;code = 121
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char = o;code = 111
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char = a;code = 97
char = s;code = 115
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char = ,;code = 44
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char = a;code = 97
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = m;code = 109
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char = d;code = 100
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char = s;code = 115
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char = s;code = 115
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char = m;code = 109
char = ;code = 32
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char = r;code = 114
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char = s;code = 115
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char = g;code = 103
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char = c;code = 99
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char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = ;code = 32
char = P;code = 80
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char = ;code = 32
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char = s;code = 115
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = m;code = 109
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ,;code = 44
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char = f;code = 102
char = e;code = 101
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char = a;code = 97
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char = D;code = 68
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char = P;code = 80
char = b;code = 98
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char = ;code = 32
char = h;code = 104
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char = b;code = 98
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char = h;code = 104
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char = n;code = 110
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = a;code = 97
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char = f;code = 102
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
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char = s;code = 115
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char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = r;code = 114
char = e;code = 101
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char = o;code = 111
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char = ;code = 32
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char = e;code = 101
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char = D;code = 68
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result sql = Environmental exposure to Pb(2+) affects hormone-mediated responses in vertebrates. To help establish the fruit fly, Drosophila melanogaster, as a model system for studying such disruption, we describe effects of Pb(2+) on hormonally regulated traits. These include duration of development, longevity, females' willingness to mate, fecundity and adult locomotor activity. Developmental Pb(2+) exposure has been shown to affect gene expression in a specific region of the Drosophila genome (approximately 122 genes) involved in lead-induced changes in adult locomotion and to affect regulation of intracellular calcium levels associated with neuronal activity at identified synapses in the larval neuromuscular junction. We suggest ways in which Drosophila could become a new model system for the study of endocrine disruptors at genetic, neural and behavioral levels of analysis, particularly by use of genomic methods. This will facilitate efforts to distinguish between behavioral effects of Pb(2+) caused by direct action on neural mechanisms versus effects of Pb(+2) on behavior mediated through endocrine disruption.
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result sql = Pb2+: an endocrine disruptor in Drosophila?
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result sql = Environmental exposure to Pb(2+) affects hormone-mediated responses in vertebrates. To help establish the fruit fly, Drosophila melanogaster, as a model system for studying such disruption, we describe effects of Pb(2+) on hormonally regulated traits. These include duration of development, longevity, females' willingness to mate, fecundity and adult locomotor activity. Developmental Pb(2+) exposure has been shown to affect gene expression in a specific region of the Drosophila genome (approximately 122 genes) involved in lead-induced changes in adult locomotion and to affect regulation of intracellular calcium levels associated with neuronal activity at identified synapses in the larval neuromuscular junction. We suggest ways in which Drosophila could become a new model system for the study of endocrine disruptors at genetic, neural and behavioral levels of analysis, particularly by use of genomic methods. This will facilitate efforts to distinguish between behavioral effects of Pb(2+) caused by direct action on neural mechanisms versus effects of Pb(+2) on behavior mediated through endocrine disruption.
Publication: Physiol. Behav. 2010 Feb 9 ;99(2)::254-9. :doi: 10.1016/j.physbeh.2009.09.014.
Publication Date: 2010 Feb 9
Study Author(s): Hirsch, Helmut V B;Possidente, Debra;Possidente, Bernard;
Institution: Department of Biological Sciences, The University at Albany, SUNY, Albany, NY 12222, USA. [email protected]
Shortcut link to this study:
Publication Date: 2010 Feb 9
Study Author(s): Hirsch, Helmut V B;Possidente, Debra;Possidente, Bernard;
Institution: Department of Biological Sciences, The University at Albany, SUNY, Albany, NY 12222, USA. [email protected]
Shortcut link to this study:
Environmental exposure to Pb(2+) affects hormone-mediated responses in vertebrates. To help establish the fruit fly, Drosophila melanogaster, as a model system for studying such disruption, we describe effects of Pb(2+) on hormonally regulated traits. These include duration of development, longevity, females' willingness to mate, fecundity and adult locomotor activity. Developmental Pb(2+) exposure has been shown to affect gene expression in a specific region of the Drosophila genome (approximately 122 genes) involved in lead-induced changes in adult locomotion and to affect regulation of intracellular calcium levels associated with neuronal activity at identified synapses in the larval neuromuscular junction. We suggest ways in which Drosophila could become a new model system for the study of endocrine disruptors at genetic, neural and behavioral levels of analysis, particularly by use of genomic methods. This will facilitate efforts to distinguish between behavioral effects of Pb(2+) caused by direct action on neural mechanisms versus effects of Pb(+2) on behavior mediated through endocrine disruption.
PMID: 19800356
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