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result sql = The NF-κB is best known for its role in inflammation. Here we show that constitutive NF-κB activity in cancer cells promotes the biosynthesis of redox scavenger glutathione (GSH), which in turn confers resistance to oxidative stress. Inhibition of NF-κB significantly decreases GSH in several lines of human leukemia and prostate cancer cells possessing high or moderate NF-κB activities. Concomitantly, NF-κB inhibition by pharmacological and molecular means sensitizes "NF-κB positive" cancer cells to chemically-induced oxidative stress and death. We propose that inhibition of NF-κB can reduce intracellular GSH in "NF-κB-positive" cancers thereby improving the efficacy of oxidative stress-based anti-cancer therapy.
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result sql = Nuclear Factor-κB modulates cellular glutathione and prevents oxidative stress in cancer cells.
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result sql = The NF-κB is best known for its role in inflammation. Here we show that constitutive NF-κB activity in cancer cells promotes the biosynthesis of redox scavenger glutathione (GSH), which in turn confers resistance to oxidative stress. Inhibition of NF-κB significantly decreases GSH in several lines of human leukemia and prostate cancer cells possessing high or moderate NF-κB activities. Concomitantly, NF-κB inhibition by pharmacological and molecular means sensitizes "NF-κB positive" cancer cells to chemically-induced oxidative stress and death. We propose that inhibition of NF-κB can reduce intracellular GSH in "NF-κB-positive" cancers thereby improving the efficacy of oxidative stress-based anti-cancer therapy.
Publication: Cancer Lett. 2010 Dec 18 ;299(1)::45-53. :doi: 10.1016/j.canlet.2010.08.002.
Publication Date: 2010 Dec 18
Study Author(s): Meng, Qinghang;Peng, Zhimin;Chen, Liang;Si, Jutong;Dong, Zhongyun;Xia, Ying;
Institution: Department of Environmental Health, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, United States.
Shortcut link to this study:
Publication Date: 2010 Dec 18
Study Author(s): Meng, Qinghang;Peng, Zhimin;Chen, Liang;Si, Jutong;Dong, Zhongyun;Xia, Ying;
Institution: Department of Environmental Health, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, United States.
Shortcut link to this study:
The NF-κB is best known for its role in inflammation. Here we show that constitutive NF-κB activity in cancer cells promotes the biosynthesis of redox scavenger glutathione (GSH), which in turn confers resistance to oxidative stress. Inhibition of NF-κB significantly decreases GSH in several lines of human leukemia and prostate cancer cells possessing high or moderate NF-κB activities. Concomitantly, NF-κB inhibition by pharmacological and molecular means sensitizes "NF-κB positive" cancer cells to chemically-induced oxidative stress and death. We propose that inhibition of NF-κB can reduce intracellular GSH in "NF-κB-positive" cancers thereby improving the efficacy of oxidative stress-based anti-cancer therapy.
PMID: 20810208
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