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result sql = Can anthracycline therapy for pediatric malignancies be less cardiotoxic?
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result sql = Anthracyclines have a central role in the treatment of cancer in pediatric patients but confer an increased risk of cardiac dysfunction. Several strategies have been employed to help reduce anthracycline-induced cardiotoxicity, including pretreating the patient with the iron chelator dexrazoxane and infusing the dose of anthracycline over a longer period. Much focus has also been placed on the development of methods that decrease the toxicity of parent compounds, specifically through the use of drug carriers such as liposomes, and on the development of new, potentially less toxic anthracycline derivatives, such as amrubicin and pixantrone. We provide a review of these strategies, focusing on studies in pediatric patients when available, and support the idea that anthracycline therapy can be less cardiotoxic in pediatric patients.
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result sql = Can anthracycline therapy for pediatric malignancies be less cardiotoxic?
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char = t;code = 116
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result sql = Anthracyclines have a central role in the treatment of cancer in pediatric patients but confer an increased risk of cardiac dysfunction. Several strategies have been employed to help reduce anthracycline-induced cardiotoxicity, including pretreating the patient with the iron chelator dexrazoxane and infusing the dose of anthracycline over a longer period. Much focus has also been placed on the development of methods that decrease the toxicity of parent compounds, specifically through the use of drug carriers such as liposomes, and on the development of new, potentially less toxic anthracycline derivatives, such as amrubicin and pixantrone. We provide a review of these strategies, focusing on studies in pediatric patients when available, and support the idea that anthracycline therapy can be less cardiotoxic in pediatric patients.
Publication: Curr Oncol Rep 2010 Nov ;12(6)::411-9. :doi: 10.1007/s11912-010-0129-9.
Publication Date: 2010 Nov
Study Author(s): Fulbright, Joy M;Huh, Winston;Anderson, Pete;Chandra, Joya;
Institution: Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, USA. [email protected]
Shortcut link to this study:
Publication Date: 2010 Nov
Study Author(s): Fulbright, Joy M;Huh, Winston;Anderson, Pete;Chandra, Joya;
Institution: Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, USA. [email protected]
Shortcut link to this study:
Anthracyclines have a central role in the treatment of cancer in pediatric patients but confer an increased risk of cardiac dysfunction. Several strategies have been employed to help reduce anthracycline-induced cardiotoxicity, including pretreating the patient with the iron chelator dexrazoxane and infusing the dose of anthracycline over a longer period. Much focus has also been placed on the development of methods that decrease the toxicity of parent compounds, specifically through the use of drug carriers such as liposomes, and on the development of new, potentially less toxic anthracycline derivatives, such as amrubicin and pixantrone. We provide a review of these strategies, focusing on studies in pediatric patients when available, and support the idea that anthracycline therapy can be less cardiotoxic in pediatric patients.
PMID: 20820959
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