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result sql = Cetuximab-conjugated magneto-fluorescent silica nanoparticles for in vivo colon cancer targeting and imaging.
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result sql = Magneto-fluorescent silica nanoparticles were conjugated with cetuximab for the targeting and imaging of colon cancer. In this study, cetuximab-conjugated magneto-fluorescent nanoparticles (MFSN-Ctx) could specifically target colon cancer cells that expressed EGFR on their cell membranes, and specific fluorescence was detected. MFSN-Ctx produced significant MRI signal changes in a human colon cancer xenograft mouse model. Intravenous injection of MFSN-Ctx resulted in faster uptake as compared to intraperitoneal injection, indicating that MFSN-Ctx had different kinetic properties in tumors based on the method of injection. The local concentration of MFSN-Ctx in a tumor was amplified by the use of an external magnetic field. These results demonstrate the potential application of MFSN-Ctx for the detection of EGFR-expressing colon cancer using in vivo imaging approaches.
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result sql = Cetuximab-conjugated magneto-fluorescent silica nanoparticles for in vivo colon cancer targeting and imaging.
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result sql = Magneto-fluorescent silica nanoparticles were conjugated with cetuximab for the targeting and imaging of colon cancer. In this study, cetuximab-conjugated magneto-fluorescent nanoparticles (MFSN-Ctx) could specifically target colon cancer cells that expressed EGFR on their cell membranes, and specific fluorescence was detected. MFSN-Ctx produced significant MRI signal changes in a human colon cancer xenograft mouse model. Intravenous injection of MFSN-Ctx resulted in faster uptake as compared to intraperitoneal injection, indicating that MFSN-Ctx had different kinetic properties in tumors based on the method of injection. The local concentration of MFSN-Ctx in a tumor was amplified by the use of an external magnetic field. These results demonstrate the potential application of MFSN-Ctx for the detection of EGFR-expressing colon cancer using in vivo imaging approaches.
Publication: Cancer Lett. 2010 Dec 18 ;299(1)::63-71.
Publication Date: 2010 Dec 18
Study Author(s): Cho, Young-Seok;Yoon, Tae-Jong;Jang, Eue-Soon;Soo Hong, Kwan;Young Lee, Shin;Ran Kim, Ok;Park, Cheongsoo;Kim, Yong-Jin;Yi, Gyu-Chul;Chang, Kiyuk;
Institution: Department of Internal Medicine, The Catholic University of Korea, 505, Banpo-dong, Seoul 137701, Republic of Korea.
Shortcut link to this study:
Publication Date: 2010 Dec 18
Study Author(s): Cho, Young-Seok;Yoon, Tae-Jong;Jang, Eue-Soon;Soo Hong, Kwan;Young Lee, Shin;Ran Kim, Ok;Park, Cheongsoo;Kim, Yong-Jin;Yi, Gyu-Chul;Chang, Kiyuk;
Institution: Department of Internal Medicine, The Catholic University of Korea, 505, Banpo-dong, Seoul 137701, Republic of Korea.
Shortcut link to this study:
Magneto-fluorescent silica nanoparticles were conjugated with cetuximab for the targeting and imaging of colon cancer. In this study, cetuximab-conjugated magneto-fluorescent nanoparticles (MFSN-Ctx) could specifically target colon cancer cells that expressed EGFR on their cell membranes, and specific fluorescence was detected. MFSN-Ctx produced significant MRI signal changes in a human colon cancer xenograft mouse model. Intravenous injection of MFSN-Ctx resulted in faster uptake as compared to intraperitoneal injection, indicating that MFSN-Ctx had different kinetic properties in tumors based on the method of injection. The local concentration of MFSN-Ctx in a tumor was amplified by the use of an external magnetic field. These results demonstrate the potential application of MFSN-Ctx for the detection of EGFR-expressing colon cancer using in vivo imaging approaches.
PMID: 20826046
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