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char = ;;code = 59
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char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = .;code = 46
result sql = Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer.
Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer.
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char = e;code = 101
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char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
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char = r;code = 114
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char = l;code = 108
char = ;code = 32
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result sql = BACKGROUND : The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk.

METHODS : Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure these 4 gene polymorphisms in 274 controls and 164 oral cancer patients.

RESULTS : Individuals with at least 1 varied G allele of GSTP1 had a 1.53-fold risk (95% confidence interval [CI] = 1.01-2.31) of developing oral cancer compared with patients with wild-type A/A homozygotes. Oral cancer patients with at least 1 varied T allele of GSTA1 gene had a 0.42-fold risk (95% CI = 0.18-0.95) of having a tumor size >2 cm compared with patients with C/C homozygotes.

CONCLUSIONS : The varied G allele of GSTP1 may be considered as a factor contributing to increased susceptibility, whereas the T allele of GSTA1 could be a protective factor for tumor size progression in Taiwanese with oral cancer.

Publication: Head Neck 2010 Aug ;32(8)::1079-87. :doi: 10.1002/hed.21297.
Publication Date: 2010 Aug
Study Author(s): Chen, Mu-Kuan;Tsai, Hsiu-Ting;Chung, Tsung-Te;Su, Shih-Chi;Kao, Te-Yu;Tseng, Hsien-Chun;Liu, Te-Hsiung;Chiou, Hui-Ling;Yang, Shun-Fa;
Institution: Department of Otorhinolaryngology-Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan.
Shortcut link to this study:
BACKGROUND : The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk.

METHODS : Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure these 4 gene polymorphisms in 274 controls and 164 oral cancer patients.

RESULTS : Individuals with at least 1 varied G allele of GSTP1 had a 1.53-fold risk (95% confidence interval [CI] = 1.01-2.31) of developing oral cancer compared with patients with wild-type A/A homozygotes. Oral cancer patients with at least 1 varied T allele of GSTA1 gene had a 0.42-fold risk (95% CI = 0.18-0.95) of having a tumor size >2 cm compared with patients with C/C homozygotes.

CONCLUSIONS : The varied G allele of GSTP1 may be considered as a factor contributing to increased susceptibility, whereas the T allele of GSTA1 could be a protective factor for tumor size progression in Taiwanese with oral cancer.
PMID: 19953622

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