char = E;code = 69 char = f;code = 102 char = f;code = 102 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = c;code = 99 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = s;code = 115 char = a;code = 97 char = f;code = 102 char = e;code = 101 char = t;code = 116 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = b;code = 98 char = i;code = 105 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = c;code = 99 char = h;code = 104 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = .;code = 46 result sql = Efficacy and safety of lubiprostone in patients with chronic constipation.
Efficacy and safety of lubiprostone in patients with chronic constipation.char = <;code = 60 char = b;code = 98 char = >;code = 62 char = A;code = 65 char = I;code = 73 char = M;code = 77 char = S;code = 83 char = ;code = 32 char = :;code = 58 char = ;code = 32 char = <;code = 60 char = /;code = 47 char = b;code = 98 char = >;code = 62 char = T;code = 84 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = i;code = 105 char = m;code = 109 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = y;code = 121 char = ;code = 32 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = a;code = 97 char = s;code = 115 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = e;code = 101 char = f;code = 102 char = f;code = 102 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = c;code = 99 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = s;code = 115 char = a;code = 97 char = f;code = 102 char = e;code = 101 char = t;code = 116 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = b;code = 98 char = i;code = 105 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = d;code = 100 char = u;code = 117 char = l;code = 108 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = c;code = 99 char = h;code = 104 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = .;code = 46 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = >;code = 62 char = M;code = 77 char = E;code = 69 char = T;code = 84 char = H;code = 72 char = O;code = 79 char = D;code = 68 char = S;code = 83 char = ;code = 32 char = :;code = 58 char = ;code = 32 char = <;code = 60 char = /;code = 47 char = b;code = 98 char = >;code = 62 char = T;code = 84 char = h;code = 104 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = m;code = 109 char = u;code = 117 char = l;code = 108 char = t;code = 116 char = i;code = 105 char = c;code = 99 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ,;code = 44 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = a;code = 97 char = l;code = 108 char = l;code = 108 char = e;code = 101 char = l;code = 108 char = -;code = 45 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = i;code = 105 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = e;code = 101 char = n;code = 110 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = l;code = 108 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = 2;code = 50 char = 3;code = 51 char = 7;code = 55 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = c;code = 99 char = h;code = 104 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = o;code = 111 char = m;code = 109 char = i;code = 105 char = z;code = 122 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = m;code = 109 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = 4;code = 52 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = k;code = 107 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = d;code = 100 char = o;code = 111 char = u;code = 117 char = b;code = 98 char = l;code = 108 char = e;code = 101 char = -;code = 45 char = b;code = 98 char = l;code = 108 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = b;code = 98 char = i;code = 105 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = 2;code = 50 char = 4;code = 52 char = ;code = 32 char = m;code = 109 char = c;code = 99 char = g;code = 103 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = p;code = 112 char = l;code = 108 char = a;code = 97 char = c;code = 99 char = e;code = 101 char = b;code = 98 char = o;code = 111 char = ;code = 32 char = t;code = 116 char = w;code = 119 char = i;code = 105 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = i;code = 105 char = l;code = 108 char = y;code = 121 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = i;code = 105 char = m;code = 109 char = a;code = 97 char = r;code = 114 char = y;code = 121 char = ;code = 32 char = e;code = 101 char = f;code = 102 char = f;code = 102 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = c;code = 99 char = y;code = 121 char = ;code = 32 char = e;code = 101 char = n;code = 110 char = d;code = 100 char = p;code = 112 char = o;code = 111 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = n;code = 110 char = u;code = 117 char = m;code = 109 char = b;code = 98 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = s;code = 115 char = p;code = 112 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = a;code = 97 char = n;code = 110 char = e;code = 101 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = b;code = 98 char = o;code = 111 char = w;code = 119 char = e;code = 101 char = l;code = 108 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = v;code = 118 char = e;code = 101 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = S;code = 83 char = B;code = 66 char = M;code = 77 char = s;code = 115 char = );code = 41 char = ;code = 32 char = a;code = 97 char = f;code = 102 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = 1;code = 49 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = k;code = 107 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = .;code = 46 char = ;code = 32 char = S;code = 83 char = e;code = 101 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = d;code = 100 char = a;code = 97 char = r;code = 114 char = y;code = 121 char = ;code = 32 char = e;code = 101 char = v;code = 118 char = a;code = 97 char = l;code = 108 char = u;code = 117 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = c;code = 99 char = l;code = 108 char = u;code = 117 char = d;code = 100 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = S;code = 83 char = B;code = 66 char = M;code = 77 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = k;code = 107 char = s;code = 115 char = ;code = 32 char = 2;code = 50 char = ,;code = 44 char = ;code = 32 char = 3;code = 51 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = 4;code = 52 char = ;;code = 59 char = ;code = 32 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = c;code = 99 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = a;code = 97 char = g;code = 103 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = S;code = 83 char = B;code = 66 char = M;code = 77 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = 2;code = 50 char = 4;code = 52 char = ;code = 32 char = h;code = 104 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = f;code = 102 char = i;code = 105 char = r;code = 114 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = y;code = 121 char = ;code = 32 char = d;code = 100 char = o;code = 111 char = s;code = 115 char = e;code = 101 char = ;;code = 59 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = o;code = 111 char = o;code = 111 char = l;code = 108 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = y;code = 121 char = ;;code = 59 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = g;code = 103 char = r;code = 114 char = e;code = 101 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;;code = 59 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = t;code = 116 char = y;code = 121 char = ;;code = 59 char = ;code = 32 char = a;code = 97 char = b;code = 98 char = d;code = 100 char = o;code = 111 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = b;code = 98 char = l;code = 108 char = o;code = 111 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = d;code = 100 char = i;code = 105 char = s;code = 115 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = t;code = 116 char = ;;code = 59 char = ;code = 32 char = g;code = 103 char = l;code = 108 char = o;code = 111 char = b;code = 98 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = e;code = 101 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = n;code = 110 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = ;;code = 59 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = s;code = 115 char = a;code = 97 char = f;code = 102 char = e;code = 101 char = t;code = 116 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = s;code = 115 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = .;code = 46 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = >;code = 62 char = R;code = 82 char = E;code = 69 char = S;code = 83 char = U;code = 85 char = L;code = 76 char = T;code = 84 char = S;code = 83 char = ;code = 32 char = :;code = 58 char = ;code = 32 char = <;code = 60 char = /;code = 47 char = b;code = 98 char = >;code = 62 char = L;code = 76 char = u;code = 117 char = b;code = 98 char = i;code = 105 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = -;code = 45 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = e;code = 101 char = x;code = 120 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = m;code = 109 char = e;code = 101 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = n;code = 110 char = u;code = 117 char = m;code = 109 char = b;code = 98 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = S;code = 83 char = B;code = 66 char = M;code = 77 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = k;code = 107 char = ;code = 32 char = 1;code = 49 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = p;code = 112 char = l;code = 108 char = a;code = 97 char = c;code = 99 char = e;code = 101 char = b;code = 98 char = o;code = 111 char = ;code = 32 char = (;code = 40 char = 5;code = 53 char = .;code = 46 char = 8;code = 56 char = 9;code = 57 char = ;code = 32 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = 3;code = 51 char = .;code = 46 char = 9;code = 57 char = 9;code = 57 char = ,;code = 44 char = ;code = 32 char = P;code = 80 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 0;code = 48 char = 0;code = 48 char = 1;code = 49 char = );code = 41 char = ,;code = 44 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = s;code = 115 char = i;code = 105 char = g;code = 103 char = n;code = 110 char = i;code = 105 char = f;code = 102 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = c;code = 99 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = a;code = 97 char = g;code = 103 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = h;code = 104 char = a;code = 97 char = v;code = 118 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = S;code = 83 char = B;code = 66 char = M;code = 77 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = 2;code = 50 char = 4;code = 52 char = ;code = 32 char = h;code = 104 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = f;code = 102 char = i;code = 105 char = r;code = 114 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = d;code = 100 char = o;code = 111 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = (;code = 40 char = 6;code = 54 char = 1;code = 49 char = .;code = 46 char = 3;code = 51 char = %;code = 37 char = ;code = 32 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = 3;code = 51 char = 1;code = 49 char = .;code = 46 char = 4;code = 52 char = %;code = 37 char = ,;code = 44 char = ;code = 32 char = P;code = 80 char = ;code = 32 char = <;code = 60 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 0;code = 48 char = 0;code = 48 char = 1;code = 49 char = );code = 41 char = .;code = 46 char = ;code = 32 char = A;code = 65 char = t;code = 116 char = ;code = 32 char = e;code = 101 char = a;code = 97 char = c;code = 99 char = h;code = 104 char = ;code = 32 char = a;code = 97 char = s;code = 115 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ,;code = 44 char = ;code = 32 char = S;code = 83 char = B;code = 66 char = M;code = 77 char = ;code = 32 char = f;code = 102 char = r;code = 114 char = e;code = 101 char = q;code = 113 char = u;code = 117 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = c;code = 99 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = a;code = 97 char = g;code = 103 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = f;code = 102 char = u;code = 117 char = l;code = 108 char = l;code = 108 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = p;code = 112 char = o;code = 111 char = n;code = 110 char = d;code = 100 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = >;code = 62 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = =;code = 61 char = 4;code = 52 char = ;code = 32 char = S;code = 83 char = B;code = 66 char = M;code = 77 char = ;code = 32 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = k;code = 107 char = );code = 41 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = i;code = 105 char = g;code = 103 char = n;code = 110 char = i;code = 105 char = f;code = 102 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = a;code = 97 char = m;code = 109 char = o;code = 111 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = b;code = 98 char = i;code = 105 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = -;code = 45 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = p;code = 112 char = l;code = 108 char = a;code = 97 char = c;code = 99 char = e;code = 101 char = b;code = 98 char = o;code = 111 char = ;code = 32 char = (;code = 40 char = P;code = 80 char = ;code = 32 char = <;code = 60 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 1;code = 49 char = 7;code = 55 char = 1;code = 49 char = );code = 41 char = .;code = 46 char = ;code = 32 char = L;code = 76 char = u;code = 117 char = b;code = 98 char = i;code = 105 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = -;code = 45 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = p;code = 112 char = o;code = 111 char = r;code = 114 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = s;code = 115 char = i;code = 105 char = g;code = 103 char = n;code = 110 char = i;code = 105 char = f;code = 102 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = i;code = 105 char = m;code = 109 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = v;code = 118 char = e;code = 101 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = o;code = 111 char = o;code = 111 char = l;code = 108 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = y;code = 121 char = ,;code = 44 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = t;code = 116 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = l;code = 108 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = k;code = 107 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = b;code = 98 char = d;code = 100 char = o;code = 111 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = b;code = 98 char = l;code = 108 char = o;code = 111 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = k;code = 107 char = ;code = 32 char = 1;code = 49 char = .;code = 46 char = ;code = 32 char = P;code = 80 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = s;code = 115 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = e;code = 101 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = n;code = 110 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = i;code = 105 char = g;code = 103 char = n;code = 110 char = i;code = 105 char = f;code = 102 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = b;code = 98 char = i;code = 105 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = p;code = 112 char = l;code = 108 char = a;code = 97 char = c;code = 99 char = e;code = 101 char = b;code = 98 char = o;code = 111 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = l;code = 108 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = k;code = 107 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = P;code = 80 char = ;code = 32 char = <;code = 60 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 0;code = 48 char = 0;code = 48 char = 4;code = 52 char = );code = 41 char = .;code = 46 char = ;code = 32 char = G;code = 71 char = a;code = 97 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = n;code = 110 char = a;code = 97 char = l;code = 108 char = -;code = 45 char = r;code = 114 char = e;code = 101 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = d;code = 100 char = i;code = 105 char = s;code = 115 char = o;code = 111 char = r;code = 114 char = d;code = 100 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = m;code = 109 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = d;code = 100 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = b;code = 98 char = o;code = 111 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = s;code = 115 char = .;code = 46 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = >;code = 62 char = C;code = 67 char = O;code = 79 char = N;code = 78 char = C;code = 67 char = L;code = 76 char = U;code = 85 char = S;code = 83 char = I;code = 73 char = O;code = 79 char = N;code = 78 char = S;code = 83 char = ;code = 32 char = :;code = 58 char = ;code = 32 char = <;code = 60 char = /;code = 47 char = b;code = 98 char = >;code = 62 char = I;code = 73 char = n;code = 110 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = c;code = 99 char = h;code = 104 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ,;code = 44 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = b;code = 98 char = i;code = 105 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = b;code = 98 char = o;code = 111 char = w;code = 119 char = e;code = 101 char = l;code = 108 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = v;code = 118 char = e;code = 101 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = m;code = 109 char = a;code = 97 char = j;code = 106 char = o;code = 111 char = r;code = 114 char = i;code = 105 char = t;code = 116 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = i;code = 105 char = v;code = 118 char = i;code = 105 char = d;code = 100 char = u;code = 117 char = a;code = 97 char = l;code = 108 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = 2;code = 50 char = 4;code = 52 char = ;code = 32 char = h;code = 104 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = t;code = 116 char = i;code = 105 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = d;code = 100 char = o;code = 111 char = s;code = 115 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ,;code = 44 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = m;code = 109 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = v;code = 118 char = e;code = 101 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = f;code = 102 char = r;code = 114 char = e;code = 101 char = q;code = 113 char = u;code = 117 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = l;code = 108 char = l;code = 108 char = ;code = 32 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = y;code = 121 char = m;code = 109 char = p;code = 112 char = t;code = 116 char = o;code = 111 char = m;code = 109 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = 4;code = 52 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = k;code = 107 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = .;code = 46 result sql = AIMS : The aim of this study is to assess the efficacy and safety of lubiprostone in adults with chronic constipation.METHODS : This multicenter, parallel-group trial enrolled 237 patients with chronic constipation and randomized them to 4 weeks of double-blind treatment with oral lubiprostone 24 mcg or placebo twice daily. The primary efficacy endpoint was the number of spontaneous bowel movements (SBMs) after 1 week of treatment. Secondary evaluations included SBMs at weeks 2, 3, and 4; percentage of patients with a SBM within 24 h of first study dose; stool consistency; degree of straining; constipation severity; abdominal bloating and discomfort; global treatment effectiveness; and safety assessments.RESULTS : Lubiprostone-treated patients experienced greater mean numbers of SBMs at week 1 compared with placebo (5.89 versus 3.99, P = 0.0001), with significantly greater percentages having SBMs within 24 h of the first dose (61.3% versus 31.4%, P < 0.0001). At each assessment, SBM frequency and percentages of full responders (> or =4 SBM per week) were significantly greater among lubiprostone-treated patients compared with placebo (P < or = 0.0171). Lubiprostone-treated patients reported significant improvements in stool consistency, straining, and constipation severity at all weeks, and in abdominal bloating at week 1. Patient assessments of treatment effectiveness were significantly greater with lubiprostone compared with placebo at all weeks (P < 0.0004). Gastrointestinal-related disorders were the most common adverse events in both treatment groups.CONCLUSIONS : In patients with chronic constipation, lubiprostone produced a bowel movement in the majority of individuals within 24 h of initial dosing, with sustained improvement in frequency as well as other constipation symptoms over 4 weeks of treatment.
Publication: Dig. Dis. Sci. 2010 Apr ;55(4)::1090-7. :doi: 10.1007/s10620-009-1068-x.
Publication Date: 2010 Apr
Study Author(s): Barish, Charles F;Drossman, Douglas;Johanson, John F;Ueno, Ryuji;
Institution: Wake Gastroenterology, Wake Research Associates, 3100 Blue Ridge Road Suite 300, Raleigh, NC, USA.
[email protected]
Shortcut link to this study:
AIMS : The aim of this study is to assess the efficacy and safety of lubiprostone in adults with chronic constipation.METHODS : This multicenter, parallel-group trial enrolled 237 patients with chronic constipation and randomized them to 4 weeks of double-blind treatment with oral lubiprostone 24 mcg or placebo twice daily. The primary efficacy endpoint was the number of spontaneous bowel movements (SBMs) after 1 week of treatment. Secondary evaluations included SBMs at weeks 2, 3, and 4; percentage of patients with a SBM within 24 h of first study dose; stool consistency; degree of straining; constipation severity; abdominal bloating and discomfort; global treatment effectiveness; and safety assessments.RESULTS : Lubiprostone-treated patients experienced greater mean numbers of SBMs at week 1 compared with placebo (5.89 versus 3.99, P = 0.0001), with significantly greater percentages having SBMs within 24 h of the first dose (61.3% versus 31.4%, P < 0.0001). At each assessment, SBM frequency and percentages of full responders (> or =4 SBM per week) were significantly greater among lubiprostone-treated patients compared with placebo (P < or = 0.0171). Lubiprostone-treated patients reported significant improvements in stool consistency, straining, and constipation severity at all weeks, and in abdominal bloating at week 1. Patient assessments of treatment effectiveness were significantly greater with lubiprostone compared with placebo at all weeks (P < 0.0004). Gastrointestinal-related disorders were the most common adverse events in both treatment groups.CONCLUSIONS : In patients with chronic constipation, lubiprostone produced a bowel movement in the majority of individuals within 24 h of initial dosing, with sustained improvement in frequency as well as other constipation symptoms over 4 weeks of treatment.
PMID: 20012484