|
|
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result sql = Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.).
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char = T;code = 84
char = E;code = 69
char = O;code = 79
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = o;code = 111
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char = u;code = 117
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = l;code = 108
char = d;code = 100
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = j;code = 106
char = o;code = 111
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = -;code = 45
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = (;code = 40
char = 2;code = 50
char = 0;code = 48
char = %;code = 37
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char = i;code = 105
char = n;code = 110
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char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = );code = 41
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = r;code = 114
char = e;code = 101
char = s;code = 115
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = d;code = 100
char = o;code = 111
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = p;code = 112
char = o;code = 111
char = r;code = 114
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = o;code = 111
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = u;code = 117
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = T;code = 84
char = E;code = 69
char = O;code = 79
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = t;code = 116
char = h;code = 104
char = r;code = 114
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char = t;code = 116
char = i;code = 105
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char = t;code = 116
char = r;code = 114
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char = a;code = 97
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char = m;code = 109
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char = b;code = 98
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char = t;code = 116
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char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = t;code = 116
char = e;code = 101
char = a;code = 97
char = d;code = 100
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = f;code = 102
char = y;code = 121
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = s;code = 115
char = a;code = 97
char = f;code = 102
char = e;code = 101
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = t;code = 116
char = e;code = 101
char = b;code = 98
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = T;code = 84
char = E;code = 69
char = O;code = 79
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = Turmeric (Curcuma longa L., Zingiberaceae) rhizomes contain two classes of secondary metabolites, curcuminoids and the less well-studied essential oils. Having previously identified potent anti-arthritic effects of the curcuminoids in turmeric extracts in an animal model of rheumatoid arthritis (RA), studies were undertaken to determine whether the turmeric essential oils (TEO) were also joint protective using the same experimental model. Crude or refined TEO extracts dramatically inhibited joint swelling (90-100% inhibition) in female rats with streptococcal cell wall (SCW)-induced arthritis when extracts were administered via intraperitoneal injection to maximize uniform delivery. However, this anti-arthritic effect was accompanied by significant morbidity and mortality. Oral administration of a 20-fold higher dose TEO was nontoxic, but only mildly joint-protective (20% inhibition). These results do not support the isolated use of TEO for arthritis treatment but, instead, identify potential safety concerns in vertebrates exposed to TEO.
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char = t;code = 116
char = i;code = 105
char = -;code = 45
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char = t;code = 116
char = h;code = 104
char = r;code = 114
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
char = i;code = 105
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char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = e;code = 101
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char = s;code = 115
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char = o;code = 111
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char = t;code = 116
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char = m;code = 109
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char = ;code = 32
char = l;code = 108
char = o;code = 111
char = n;code = 110
char = g;code = 103
char = a;code = 97
char = ;code = 32
char = L;code = 76
char = .;code = 46
char = );code = 41
char = .;code = 46
result sql = Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.).
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char = r;code = 114
char = m;code = 109
char = e;code = 101
char = r;code = 114
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char = c;code = 99
char = u;code = 117
char = m;code = 109
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char = l;code = 108
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char = g;code = 103
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char = c;code = 99
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char = ;code = 32
char = s;code = 115
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char = c;code = 99
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char = e;code = 101
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char = o;code = 111
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char = e;code = 101
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char = h;code = 104
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char = i;code = 105
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char = i;code = 105
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char = e;code = 101
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char = e;code = 101
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char = ;code = 32
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char = h;code = 104
char = e;code = 101
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char = c;code = 99
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
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char = i;code = 105
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char = a;code = 97
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char = m;code = 109
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char = e;code = 101
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char = ;code = 32
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char = h;code = 104
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char = u;code = 117
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char = o;code = 111
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char = ;code = 32
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char = t;code = 116
char = h;code = 104
char = r;code = 114
char = i;code = 105
char = t;code = 116
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char = ;code = 32
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char = R;code = 82
char = A;code = 65
char = );code = 41
char = ,;code = 44
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char = s;code = 115
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char = u;code = 117
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char = u;code = 117
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char = e;code = 101
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char = t;code = 116
char = a;code = 97
char = k;code = 107
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char = n;code = 110
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char = o;code = 111
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char = d;code = 100
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char = e;code = 101
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char = m;code = 109
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char = e;code = 101
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = t;code = 116
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char = e;code = 101
char = ;code = 32
char = a;code = 97
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char = s;code = 115
char = o;code = 111
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char = j;code = 106
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char = e;code = 101
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char = a;code = 97
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char = l;code = 108
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char = (;code = 40
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result sql = Turmeric (Curcuma longa L., Zingiberaceae) rhizomes contain two classes of secondary metabolites, curcuminoids and the less well-studied essential oils. Having previously identified potent anti-arthritic effects of the curcuminoids in turmeric extracts in an animal model of rheumatoid arthritis (RA), studies were undertaken to determine whether the turmeric essential oils (TEO) were also joint protective using the same experimental model. Crude or refined TEO extracts dramatically inhibited joint swelling (90-100% inhibition) in female rats with streptococcal cell wall (SCW)-induced arthritis when extracts were administered via intraperitoneal injection to maximize uniform delivery. However, this anti-arthritic effect was accompanied by significant morbidity and mortality. Oral administration of a 20-fold higher dose TEO was nontoxic, but only mildly joint-protective (20% inhibition). These results do not support the isolated use of TEO for arthritis treatment but, instead, identify potential safety concerns in vertebrates exposed to TEO.
Publication: J. Agric. Food Chem. 2010 Jan 27 ;58(2)::842-9.
Publication Date: 2010 Jan 27
Study Author(s): Funk, Janet L;Frye, Jennifer B;Oyarzo, Janice N;Zhang, Huaping;Timmermann, Barbara N;
Institution: Department of Medicine, University of Arizona, Tucson, Arizona 85724, USA. [email protected]
Shortcut link to this study:
Publication Date: 2010 Jan 27
Study Author(s): Funk, Janet L;Frye, Jennifer B;Oyarzo, Janice N;Zhang, Huaping;Timmermann, Barbara N;
Institution: Department of Medicine, University of Arizona, Tucson, Arizona 85724, USA. [email protected]
Shortcut link to this study:
Turmeric (Curcuma longa L., Zingiberaceae) rhizomes contain two classes of secondary metabolites, curcuminoids and the less well-studied essential oils. Having previously identified potent anti-arthritic effects of the curcuminoids in turmeric extracts in an animal model of rheumatoid arthritis (RA), studies were undertaken to determine whether the turmeric essential oils (TEO) were also joint protective using the same experimental model. Crude or refined TEO extracts dramatically inhibited joint swelling (90-100% inhibition) in female rats with streptococcal cell wall (SCW)-induced arthritis when extracts were administered via intraperitoneal injection to maximize uniform delivery. However, this anti-arthritic effect was accompanied by significant morbidity and mortality. Oral administration of a 20-fold higher dose TEO was nontoxic, but only mildly joint-protective (20% inhibition). These results do not support the isolated use of TEO for arthritis treatment but, instead, identify potential safety concerns in vertebrates exposed to TEO.
PMID: 20025215
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