|
|
char = S;code = 83
char = y;code = 121
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char = s;code = 115
char = ;code = 32
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char = d;code = 100
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char = r;code = 114
char = o;code = 111
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char = ;code = 32
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char = o;code = 111
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char = l;code = 108
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char = n;code = 110
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char = a;code = 97
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = .;code = 46
result sql = Synthesis of 3-amino-4-hydroxy coumarin and dihydroxy-phenyl coumarins as novel anticoagulants.
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char = a;code = 97
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char = u;code = 117
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char = d;code = 100
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char = i;code = 105
char = t;code = 116
char = h;code = 104
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char = o;code = 111
char = m;code = 109
char = b;code = 98
char = o;code = 111
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char = c;code = 99
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char = a;code = 97
char = c;code = 99
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char = i;code = 105
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char = i;code = 105
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char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
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char = h;code = 104
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char = e;code = 101
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char = b;code = 98
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char = i;code = 105
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char = a;code = 97
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char = 3;code = 51
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char = A;code = 65
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char = ,;code = 44
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char = 5;code = 53
char = ,;code = 44
char = 7;code = 55
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char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = x;code = 120
char = y;code = 121
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char = 4;code = 52
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result sql = Natural and synthetic coumarin derivatives have been shown to possess several beneficial pharmacological effects. The anticoagulation and antithrombotic activities of the 4-hydroxy coumarin derivatives are well known. In this study, besides the 4-hydroxy substituent phenyl and p-methylphenyl derivatives were synthesized and confirmed on the basis of their spectral data. 3-Amino-4-hydroxy coumarin, 5,7-dihydroxy-4-phenyl coumarin and 7,8-dihydroxy-3-(4-methylphenyl)coumarin were tested in rats to determine whether they had any effect on vitamin K inhibition by investigating the prothrombin time (PT). PT values of coumarin derivatives were compared with those of warfarin (CAS 81-81-2), which is the most commonly used anticoagulant. 7,8-Dihydroxy-3-(4-methylphenyl)coumarin increased PT when compared to saline treated control group and other coumarins synthesized, 3-amino-4-hydroxy coumarin and 5,7-dihydroxy-4-phenyl coumarin.
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char = o;code = 111
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char = .;code = 46
result sql = Synthesis of 3-amino-4-hydroxy coumarin and dihydroxy-phenyl coumarins as novel anticoagulants.
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result sql = Natural and synthetic coumarin derivatives have been shown to possess several beneficial pharmacological effects. The anticoagulation and antithrombotic activities of the 4-hydroxy coumarin derivatives are well known. In this study, besides the 4-hydroxy substituent phenyl and p-methylphenyl derivatives were synthesized and confirmed on the basis of their spectral data. 3-Amino-4-hydroxy coumarin, 5,7-dihydroxy-4-phenyl coumarin and 7,8-dihydroxy-3-(4-methylphenyl)coumarin were tested in rats to determine whether they had any effect on vitamin K inhibition by investigating the prothrombin time (PT). PT values of coumarin derivatives were compared with those of warfarin (CAS 81-81-2), which is the most commonly used anticoagulant. 7,8-Dihydroxy-3-(4-methylphenyl)coumarin increased PT when compared to saline treated control group and other coumarins synthesized, 3-amino-4-hydroxy coumarin and 5,7-dihydroxy-4-phenyl coumarin.
Publication: Arzneimittelforschung 2010 ;60(10)::617-20. :doi: 10.1055/s-0031-1296335.
Publication Date: 2010
Study Author(s): Danis, Ozkan;Yuce-Dursun, Basak;Gunduz, Cihan;Ogan, Ayse;Sener, Goksel;Bulut, Mustafa;Yarat, Aysen;
Institution: Marmara University, Faculty of Science and Letters, Department of Chemistry, Goztepe, Istanbul, Turkey. [email protected]
Shortcut link to this study:
Publication Date: 2010
Study Author(s): Danis, Ozkan;Yuce-Dursun, Basak;Gunduz, Cihan;Ogan, Ayse;Sener, Goksel;Bulut, Mustafa;Yarat, Aysen;
Institution: Marmara University, Faculty of Science and Letters, Department of Chemistry, Goztepe, Istanbul, Turkey. [email protected]
Shortcut link to this study:
Natural and synthetic coumarin derivatives have been shown to possess several beneficial pharmacological effects. The anticoagulation and antithrombotic activities of the 4-hydroxy coumarin derivatives are well known. In this study, besides the 4-hydroxy substituent phenyl and p-methylphenyl derivatives were synthesized and confirmed on the basis of their spectral data. 3-Amino-4-hydroxy coumarin, 5,7-dihydroxy-4-phenyl coumarin and 7,8-dihydroxy-3-(4-methylphenyl)coumarin were tested in rats to determine whether they had any effect on vitamin K inhibition by investigating the prothrombin time (PT). PT values of coumarin derivatives were compared with those of warfarin (CAS 81-81-2), which is the most commonly used anticoagulant. 7,8-Dihydroxy-3-(4-methylphenyl)coumarin increased PT when compared to saline treated control group and other coumarins synthesized, 3-amino-4-hydroxy coumarin and 5,7-dihydroxy-4-phenyl coumarin.
PMID: 21125812
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