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result sql = Efficacy and safety of silexan, a new, orally administered lavender oil preparation, in subthreshold anxiety disorder - evidence from clinical trials.
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result sql = We review the data on the efficacy and tolerability of silexan, a novel preparation from lavender oil for oral use, in the treatment of anxiety disorders and related condition with particular attention to subthreshold generalized anxiety disorder (GAD). Three randomized, double-blind clinical trials were identified which investigated the efficacy of silexan in subsynromal anxiety disorder (vs. placebo; 10 weeks' treatment), in GAD (vs. lorazepam; 6 weeks), and in restlessness and agitation (vs. placebo; 10 weeks) according to DSM-IV and ICD-10 criteria. All trials assessed the participants' anxiety levels using the Hamilton Anxiety Scale (HAMA). Across all trials 280 patients were exposed to silexan 80 mg/day, 37 were treated with lorazepam 0.5 mg/day and 192 received placebo. Average within group HAMA total scores at baseline ranged between 24.7 and 27.1 points. Patients treated with silexan showed average HAMA total score decreases by between 10.4 ± 7.1 and 12.0 ± 7.2 points at week 6 and by between 11.8 ± 7.7 and 16.0 ± 8.3 points at week 10. In GAD silexan and lorazepam showed comparable HAMA total score reductions (90% CI for mean value difference: -2.3; 2.8 points).
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result sql = Efficacy and safety of silexan, a new, orally administered lavender oil preparation, in subthreshold anxiety disorder - evidence from clinical trials.
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char = e;code = 101
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char = e;code = 101
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char = c;code = 99
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char = i;code = 105
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char = e;code = 101
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char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = f;code = 102
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char = i;code = 105
char = n;code = 110
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char = u;code = 117
char = b;code = 98
char = s;code = 115
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char = a;code = 97
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char = a;code = 97
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char = e;code = 101
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char = i;code = 105
char = s;code = 115
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char = e;code = 101
char = r;code = 114
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char = s;code = 115
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char = ;code = 32
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = c;code = 99
char = e;code = 101
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char = ;code = 32
char = 1;code = 49
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char = w;code = 119
char = e;code = 101
char = e;code = 101
char = k;code = 107
char = s;code = 115
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char = ;code = 32
char = t;code = 116
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char = e;code = 101
char = a;code = 97
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char = n;code = 110
char = t;code = 116
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char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = G;code = 71
char = A;code = 65
char = D;code = 68
char = ;code = 32
char = (;code = 40
char = v;code = 118
char = s;code = 115
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char = ;code = 32
char = l;code = 108
char = o;code = 111
char = r;code = 114
char = a;code = 97
char = z;code = 122
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = m;code = 109
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char = ;code = 32
char = 6;code = 54
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = e;code = 101
char = k;code = 107
char = s;code = 115
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char = ,;code = 44
char = ;code = 32
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char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = r;code = 114
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char = s;code = 115
char = t;code = 116
char = l;code = 108
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = (;code = 40
char = v;code = 118
char = s;code = 115
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char = ;code = 32
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = b;code = 98
char = o;code = 111
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char = ;code = 32
char = 1;code = 49
char = 0;code = 48
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = e;code = 101
char = k;code = 107
char = s;code = 115
char = );code = 41
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = c;code = 99
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char = d;code = 100
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = D;code = 68
char = S;code = 83
char = M;code = 77
char = -;code = 45
char = I;code = 73
char = V;code = 86
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = I;code = 73
char = C;code = 67
char = D;code = 68
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char = 1;code = 49
char = 0;code = 48
char = ;code = 32
char = c;code = 99
char = r;code = 114
char = i;code = 105
char = t;code = 116
char = e;code = 101
char = r;code = 114
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char = a;code = 97
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char = ;code = 32
char = A;code = 65
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char = l;code = 108
char = ;code = 32
char = t;code = 116
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char = a;code = 97
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char = s;code = 115
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char = a;code = 97
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = e;code = 101
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char = e;code = 101
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char = a;code = 97
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char = t;code = 116
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = p;code = 112
char = a;code = 97
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char = s;code = 115
char = ';code = 39
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = x;code = 120
char = i;code = 105
char = e;code = 101
char = t;code = 116
char = y;code = 121
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char = l;code = 108
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = s;code = 115
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char = u;code = 117
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = H;code = 72
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = l;code = 108
char = t;code = 116
char = o;code = 111
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char = A;code = 65
char = n;code = 110
char = x;code = 120
char = i;code = 105
char = e;code = 101
char = t;code = 116
char = y;code = 121
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char = S;code = 83
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = H;code = 72
char = A;code = 65
char = M;code = 77
char = A;code = 65
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char = .;code = 46
char = ;code = 32
char = A;code = 65
char = c;code = 99
char = r;code = 114
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char = s;code = 115
char = ;code = 32
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char = l;code = 108
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char = a;code = 97
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char = s;code = 115
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char = a;code = 97
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char = r;code = 114
char = a;code = 97
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char = i;code = 105
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char = r;code = 114
char = o;code = 111
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char = p;code = 112
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char = H;code = 72
char = A;code = 65
char = M;code = 77
char = A;code = 65
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char = t;code = 116
char = o;code = 111
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char = a;code = 97
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char = i;code = 105
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char = P;code = 80
char = a;code = 97
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char = i;code = 105
char = e;code = 101
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char = a;code = 97
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char = H;code = 72
char = A;code = 65
char = M;code = 77
char = A;code = 65
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char = t;code = 116
char = o;code = 111
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char = a;code = 97
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char = w;code = 119
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char = e;code = 101
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char = D;code = 68
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char = b;code = 98
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char = H;code = 72
char = A;code = 65
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char = A;code = 65
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char = t;code = 116
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char = (;code = 40
char = 9;code = 57
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char = %;code = 37
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char = C;code = 67
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char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = a;code = 97
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char = :;code = 58
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char = 2;code = 50
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char = .;code = 46
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result sql = We review the data on the efficacy and tolerability of silexan, a novel preparation from lavender oil for oral use, in the treatment of anxiety disorders and related condition with particular attention to subthreshold generalized anxiety disorder (GAD). Three randomized, double-blind clinical trials were identified which investigated the efficacy of silexan in subsynromal anxiety disorder (vs. placebo; 10 weeks' treatment), in GAD (vs. lorazepam; 6 weeks), and in restlessness and agitation (vs. placebo; 10 weeks) according to DSM-IV and ICD-10 criteria. All trials assessed the participants' anxiety levels using the Hamilton Anxiety Scale (HAMA). Across all trials 280 patients were exposed to silexan 80 mg/day, 37 were treated with lorazepam 0.5 mg/day and 192 received placebo. Average within group HAMA total scores at baseline ranged between 24.7 and 27.1 points. Patients treated with silexan showed average HAMA total score decreases by between 10.4 ± 7.1 and 12.0 ± 7.2 points at week 6 and by between 11.8 ± 7.7 and 16.0 ± 8.3 points at week 10. In GAD silexan and lorazepam showed comparable HAMA total score reductions (90% CI for mean value difference: -2.3; 2.8 points).
Publication: Wien Med Wochenschr 2010 Dec ;160(21-22)::547-56. :doi: 10.1007/s10354-010-0845-7.
Publication Date: 2010 Dec
Study Author(s): Kasper, Siegfried;Gastpar, Markus;Müller, Walter E;Volz, Hans-Peter;Möller, Hans-Jürgen;Dienel, Angelika;Schläfke, Sandra;
Institution: Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria. [email protected]
Shortcut link to this study:
Publication Date: 2010 Dec
Study Author(s): Kasper, Siegfried;Gastpar, Markus;Müller, Walter E;Volz, Hans-Peter;Möller, Hans-Jürgen;Dienel, Angelika;Schläfke, Sandra;
Institution: Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria. [email protected]
Shortcut link to this study:
We review the data on the efficacy and tolerability of silexan, a novel preparation from lavender oil for oral use, in the treatment of anxiety disorders and related condition with particular attention to subthreshold generalized anxiety disorder (GAD). Three randomized, double-blind clinical trials were identified which investigated the efficacy of silexan in subsynromal anxiety disorder (vs. placebo; 10 weeks' treatment), in GAD (vs. lorazepam; 6 weeks), and in restlessness and agitation (vs. placebo; 10 weeks) according to DSM-IV and ICD-10 criteria. All trials assessed the participants' anxiety levels using the Hamilton Anxiety Scale (HAMA). Across all trials 280 patients were exposed to silexan 80 mg/day, 37 were treated with lorazepam 0.5 mg/day and 192 received placebo. Average within group HAMA total scores at baseline ranged between 24.7 and 27.1 points. Patients treated with silexan showed average HAMA total score decreases by between 10.4 ± 7.1 and 12.0 ± 7.2 points at week 6 and by between 11.8 ± 7.7 and 16.0 ± 8.3 points at week 10. In GAD silexan and lorazepam showed comparable HAMA total score reductions (90% CI for mean value difference: -2.3; 2.8 points).
PMID: 21170695
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