|
|
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result sql = Actions of vitamin D are mediated by the TLR4 pathway in inflammation-induced colon cancer.
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char = ;code = 32
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char = s;code = 115
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char = g;code = 103
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = i;code = 105
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char = r;code = 114
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char = g;code = 103
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char = a;code = 97
char = t;code = 116
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char = a;code = 97
char = t;code = 116
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char = 5;code = 53
char = ;code = 32
char = a;code = 97
char = r;code = 114
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char = ;code = 32
char = e;code = 101
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = p;code = 112
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result sql = Many chronic inflammatory diseases are associated with increased risk of developing cancer. In the colon, strong support for a link between chronic inflammation and cancer extends, in part, from population-based studies of persons with inflammatory bowel disease (IBD). Patients with IBD are at increased risk of developing colorectal cancer (CRC). The general consensus is that IBD results from the combined effects of genetics and environment factors known to affect the immune system. Vitamin D, an important regulator of the immune system, has been linked to IBD. Despite the strong potential reported for 1,25-dihydroxyvitamin D (1,25-OH)2D), its effects on calcium metabolism limits its application. Recently, less active vitamin D metabolites, cholecalciferol and 25-hydroxyvitamin D (25(OH)D), have gained considerable attention as promising agents against IBD-related colon cancer. Yet, their anti-proliferative properties and mechanism of action remain to be better defined. We present several signaling pathways commonly regulated by vitamin D compounds and highlight their regulation on TLR4. The efficacy of 25(OH)D and 1alpha-hydroxyviatmin D5 are evaluated using the azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced IBD-related colon carcinogenesis model. In summary, vitamin D supplementation may provide a cost-effective approach to reduce IBD related colon cancer.
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char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = D;code = 68
char = ;code = 32
char = a;code = 97
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char = e;code = 101
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char = m;code = 109
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = T;code = 84
char = L;code = 76
char = R;code = 82
char = 4;code = 52
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = w;code = 119
char = a;code = 97
char = y;code = 121
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char = i;code = 105
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char = l;code = 108
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char = m;code = 109
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char = c;code = 99
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char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = .;code = 46
result sql = Actions of vitamin D are mediated by the TLR4 pathway in inflammation-induced colon cancer.
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char = t;code = 116
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char = m;code = 109
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char = .;code = 46
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char = P;code = 80
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char = t;code = 116
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char = D;code = 68
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char = a;code = 97
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char = a;code = 97
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char = s;code = 115
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char = o;code = 111
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char = a;code = 97
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char = c;code = 99
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char = r;code = 114
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char = R;code = 82
char = C;code = 67
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char = .;code = 46
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char = s;code = 115
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char = t;code = 116
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char = a;code = 97
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char = I;code = 73
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char = r;code = 114
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char = s;code = 115
char = u;code = 117
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char = t;code = 116
char = s;code = 115
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char = f;code = 102
char = r;code = 114
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char = m;code = 109
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char = t;code = 116
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char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = f;code = 102
char = ;code = 32
char = g;code = 103
char = e;code = 101
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char = e;code = 101
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char = c;code = 99
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char = a;code = 97
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char = d;code = 100
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char = e;code = 101
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char = v;code = 118
char = i;code = 105
char = r;code = 114
char = o;code = 111
char = n;code = 110
char = m;code = 109
char = e;code = 101
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char = t;code = 116
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char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
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char = s;code = 115
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char = k;code = 107
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char = o;code = 111
char = w;code = 119
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char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = t;code = 116
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char = e;code = 101
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char = m;code = 109
char = m;code = 109
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char = s;code = 115
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char = s;code = 115
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char = i;code = 105
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char = u;code = 117
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char = a;code = 97
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char = o;code = 111
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char = b;code = 98
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char = .;code = 46
char = ;code = 32
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char = a;code = 97
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char = a;code = 97
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char = f;code = 102
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char = v;code = 118
char = e;code = 101
char = ;code = 32
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char = p;code = 112
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result sql = Many chronic inflammatory diseases are associated with increased risk of developing cancer. In the colon, strong support for a link between chronic inflammation and cancer extends, in part, from population-based studies of persons with inflammatory bowel disease (IBD). Patients with IBD are at increased risk of developing colorectal cancer (CRC). The general consensus is that IBD results from the combined effects of genetics and environment factors known to affect the immune system. Vitamin D, an important regulator of the immune system, has been linked to IBD. Despite the strong potential reported for 1,25-dihydroxyvitamin D (1,25-OH)2D), its effects on calcium metabolism limits its application. Recently, less active vitamin D metabolites, cholecalciferol and 25-hydroxyvitamin D (25(OH)D), have gained considerable attention as promising agents against IBD-related colon cancer. Yet, their anti-proliferative properties and mechanism of action remain to be better defined. We present several signaling pathways commonly regulated by vitamin D compounds and highlight their regulation on TLR4. The efficacy of 25(OH)D and 1alpha-hydroxyviatmin D5 are evaluated using the azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced IBD-related colon carcinogenesis model. In summary, vitamin D supplementation may provide a cost-effective approach to reduce IBD related colon cancer.
Publication: J. Steroid Biochem. Mol. Biol. 2010 Jul ;121(1-2)::403-7. :doi: 10.1016/j.jsbmb.2010.03.009.
Publication Date: 2010 Jul
Study Author(s): Murillo, G;Nagpal, V;Tiwari, N;Benya, R V;Mehta, R G;
Institution: Division of Carcinogenesis and Chemoprevention, IIT Research Institute, Chicago, IL 60616, USA. [email protected]
Shortcut link to this study:
Publication Date: 2010 Jul
Study Author(s): Murillo, G;Nagpal, V;Tiwari, N;Benya, R V;Mehta, R G;
Institution: Division of Carcinogenesis and Chemoprevention, IIT Research Institute, Chicago, IL 60616, USA. [email protected]
Shortcut link to this study:
Many chronic inflammatory diseases are associated with increased risk of developing cancer. In the colon, strong support for a link between chronic inflammation and cancer extends, in part, from population-based studies of persons with inflammatory bowel disease (IBD). Patients with IBD are at increased risk of developing colorectal cancer (CRC). The general consensus is that IBD results from the combined effects of genetics and environment factors known to affect the immune system. Vitamin D, an important regulator of the immune system, has been linked to IBD. Despite the strong potential reported for 1,25-dihydroxyvitamin D (1,25-OH)2D), its effects on calcium metabolism limits its application. Recently, less active vitamin D metabolites, cholecalciferol and 25-hydroxyvitamin D (25(OH)D), have gained considerable attention as promising agents against IBD-related colon cancer. Yet, their anti-proliferative properties and mechanism of action remain to be better defined. We present several signaling pathways commonly regulated by vitamin D compounds and highlight their regulation on TLR4. The efficacy of 25(OH)D and 1alpha-hydroxyviatmin D5 are evaluated using the azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced IBD-related colon carcinogenesis model. In summary, vitamin D supplementation may provide a cost-effective approach to reduce IBD related colon cancer.
PMID: 20214986
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