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result sql = Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model.
Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model.
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result sql = Curcumin can decrease viable cells through the induction of apoptosis in human lung cancer NCI-H460 cells in vitro. However, there are no reports that curcumin can inhibit cancer cells in vivo. In this study, NCI-H460 lung tumour cells were implanted directly into nude mice and divided randomly into four groups to be treated with vehicle, curcumin (30 mg/kg of body weight), curcumin (45 mg/kg of body weight) and doxorubicin (8 mg/kg of body weight). Each agent was injected once every 4 days intraperitoneally (i.p.), with treatment starting 4 weeks after inoculation with the NCI-H460 cells. Treatment with 30 mg/kg and 45 mg/kg of curcumin or with 8 mg/kg of doxorubicin resulted in a reduction in tumour incidence, size and weight compared with the control group. The findings indicate that curcumin can inhibit tumour growth in a NCI-H460 xenograft animal model in vivo.

Publication: Phytother Res 2010 Feb ;24(2)::189-92. :doi: 10.1002/ptr.2905.
Publication Date: 2010 Feb
Study Author(s): Su, Chin-Cheng;Yang, Jai-Sing;Lu, Chi-Cheng;Chiang, Jo-Hua;Wu, Chang-Lin;Lin, Jen-Jyh;Lai, Kuang-Chi;Hsia, Te-Chun;Lu, Hsu-Feng;Fan, Ming-Jen;Chung, Jing-Gung;
Institution: Division of General Surgery, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien 970, Taiwan.
Shortcut link to this study:
Curcumin can decrease viable cells through the induction of apoptosis in human lung cancer NCI-H460 cells in vitro. However, there are no reports that curcumin can inhibit cancer cells in vivo. In this study, NCI-H460 lung tumour cells were implanted directly into nude mice and divided randomly into four groups to be treated with vehicle, curcumin (30 mg/kg of body weight), curcumin (45 mg/kg of body weight) and doxorubicin (8 mg/kg of body weight). Each agent was injected once every 4 days intraperitoneally (i.p.), with treatment starting 4 weeks after inoculation with the NCI-H460 cells. Treatment with 30 mg/kg and 45 mg/kg of curcumin or with 8 mg/kg of doxorubicin resulted in a reduction in tumour incidence, size and weight compared with the control group. The findings indicate that curcumin can inhibit tumour growth in a NCI-H460 xenograft animal model in vivo.
PMID: 20077433

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