|
|
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result sql = HDL lipids and insulin resistance.
HDL lipids and insulin resistance.char = T;code = 84
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char = o;code = 111
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char = e;code = 101
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char = f;code = 102
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char = >;code = 62
result sql = There is renewed interest in high-density lipoproteins (HDLs) due to recent findings linking atherosclerosis to the formation of dysfunctional HDL. This article focuses on the universe of HDL lipids and their potential protective or proinflammatory roles in vascular disease and insulin resistance. HDL carries a wide array of lipids including sterols, triglycerides, fat-soluble vitamins, and a large number of phospholipids, including phosphatidylcholine, sphingomyelin, and ceramide with many biological functions. Ceramide has been implicated in the pathogenesis of insulin resistance and has many proinflammatory properties. In contrast, sphingosine-1-phosphate, which is transported mainly in HDL, has anti-inflammatory properties that may be atheroprotective and may account for some of the beneficial effects of HDL. However, the complexity of the HDL lipidome is only beginning to reveal itself. The emergence of new analytical technologies should rapidly increase our understanding of the function of HDL lipids and their role in disease states.
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char = l;code = 108
char = i;code = 105
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char = i;code = 105
char = d;code = 100
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char = ;code = 32
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char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = u;code = 117
char = l;code = 108
char = i;code = 105
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char = s;code = 115
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = .;code = 46
result sql = HDL lipids and insulin resistance.
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result sql = There is renewed interest in high-density lipoproteins (HDLs) due to recent findings linking atherosclerosis to the formation of dysfunctional HDL. This article focuses on the universe of HDL lipids and their potential protective or proinflammatory roles in vascular disease and insulin resistance. HDL carries a wide array of lipids including sterols, triglycerides, fat-soluble vitamins, and a large number of phospholipids, including phosphatidylcholine, sphingomyelin, and ceramide with many biological functions. Ceramide has been implicated in the pathogenesis of insulin resistance and has many proinflammatory properties. In contrast, sphingosine-1-phosphate, which is transported mainly in HDL, has anti-inflammatory properties that may be atheroprotective and may account for some of the beneficial effects of HDL. However, the complexity of the HDL lipidome is only beginning to reveal itself. The emergence of new analytical technologies should rapidly increase our understanding of the function of HDL lipids and their role in disease states.
Publication: Curr. Diab. Rep. 2010 Feb ;10(1)::78-86. :doi: 10.1007/s11892-009-0085-7.
Publication Date: 2010 Feb
Study Author(s): Hoofnagle, Andrew N;Vaisar, Tomas;Mitra, Poulami;Chait, Alan;
Institution: Department of Laboratory Medicine, University of Washington School of Medicine, Mailstop 358055, 815 Mercer Street, Seattle, WA 98109, USA.
Shortcut link to this study:
Publication Date: 2010 Feb
Study Author(s): Hoofnagle, Andrew N;Vaisar, Tomas;Mitra, Poulami;Chait, Alan;
Institution: Department of Laboratory Medicine, University of Washington School of Medicine, Mailstop 358055, 815 Mercer Street, Seattle, WA 98109, USA.
Shortcut link to this study:
There is renewed interest in high-density lipoproteins (HDLs) due to recent findings linking atherosclerosis to the formation of dysfunctional HDL. This article focuses on the universe of HDL lipids and their potential protective or proinflammatory roles in vascular disease and insulin resistance. HDL carries a wide array of lipids including sterols, triglycerides, fat-soluble vitamins, and a large number of phospholipids, including phosphatidylcholine, sphingomyelin, and ceramide with many biological functions. Ceramide has been implicated in the pathogenesis of insulin resistance and has many proinflammatory properties. In contrast, sphingosine-1-phosphate, which is transported mainly in HDL, has anti-inflammatory properties that may be atheroprotective and may account for some of the beneficial effects of HDL. However, the complexity of the HDL lipidome is only beginning to reveal itself. The emergence of new analytical technologies should rapidly increase our understanding of the function of HDL lipids and their role in disease states.
PMID: 20425071
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