|
|
char = B;code = 66
char = u;code = 117
char = t;code = 116
char = y;code = 121
char = r;code = 114
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = ;code = 32
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char = u;code = 117
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char = s;code = 115
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char = a;code = 97
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = a;code = 97
char = ;code = 32
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char = x;code = 120
char = i;code = 105
char = d;code = 100
char = a;code = 97
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char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = t;code = 116
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char = s;code = 115
char = s;code = 115
char = ;code = 32
char = i;code = 105
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char = J;code = 74
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char = r;code = 114
char = k;code = 107
char = a;code = 97
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char = ;code = 32
char = T;code = 84
char = -;code = 45
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = Butyric acid induces apoptosis via oxidative stress in Jurkat T-cells.
Butyric acid induces apoptosis via oxidative stress in Jurkat T-cells.char = R;code = 82
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char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
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char = n;code = 110
char = ;code = 32
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = R;code = 82
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char = S;code = 83
char = );code = 41
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
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char = e;code = 101
char = s;code = 115
char = s;code = 115
char = e;code = 101
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char = a;code = 97
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char = ;code = 32
char = f;code = 102
char = o;code = 111
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = c;code = 99
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char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = T;code = 84
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char = l;code = 108
char = ;code = 32
char = a;code = 97
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char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
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char = i;code = 105
char = s;code = 115
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char = ;code = 32
char = b;code = 98
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char = a;code = 97
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char = l;code = 108
char = u;code = 117
char = l;code = 108
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char = m;code = 109
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char = a;code = 97
char = b;code = 98
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char = p;code = 112
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char = i;code = 105
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char = d;code = 100
char = o;code = 111
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char = o;code = 111
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char = a;code = 97
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = b;code = 98
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = e;code = 101
char = r;code = 114
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char = a;code = 97
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = o;code = 111
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char = d;code = 100
char = e;code = 101
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char = e;code = 101
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char = ;code = 32
char = o;code = 111
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char = a;code = 97
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char = t;code = 116
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = i;code = 105
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char = p;code = 112
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = R;code = 82
char = O;code = 79
char = S;code = 83
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char = i;code = 105
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char = m;code = 109
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char = o;code = 111
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char = s;code = 115
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char = g;code = 103
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char = a;code = 97
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char = c;code = 99
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char = o;code = 111
char = r;code = 114
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char = i;code = 105
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char = i;code = 105
char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = s;code = 115
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char = w;code = 119
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char = y;code = 121
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char = u;code = 117
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char = s;code = 115
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char = b;code = 98
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char = t;code = 116
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char = c;code = 99
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char = i;code = 105
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char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = T;code = 84
char = -;code = 45
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = N;code = 78
char = -;code = 45
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = t;code = 116
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char = L;code = 76
char = -;code = 45
char = C;code = 67
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char = t;code = 116
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char = (;code = 40
char = N;code = 78
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char = C;code = 67
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char = a;code = 97
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char = a;code = 97
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char = e;code = 101
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char = B;code = 66
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char = 2;code = 50
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char = b;code = 98
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char = g;code = 103
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result sql = Reactive oxygen species (ROS) are essential for the induction of T-cell apoptosis by butyric acid, an extracellular metabolite of periodontopathic bacteria. To determine the involvement of oxidative stress in apoptosis pathways, we investigated the contribution of ROS in mitochondrial signaling pathways, death-receptor-initiated signaling pathway, and endoplasmic reticulum stress in butyric-acid-induced T-cell apoptosis. N-acetyl-L-Cysteine (NAC) abrogated mitochondrial injury, cytochrome c, AIF, and Smac release, and Bcl-2 and Bcl-xL suppression and Bax and Bad activation induced by butyric acid. However, the decrease in cFLIP expression by butyric acid was not restored by treatment with NAC; increases in caspase-4 and -10 activities by butyric acid were completely abrogated by NAC. NAC also affected the elevation of GRP78 and CHOP/GADD153 expression by butyric acid. These results suggest that butyric acid is involved in mitochondrial-dysfunction- and endoplasmic reticulum stress-mediated apoptosis in human Jurkat T-cells via a ROS-dependent mechanism.
char = u;code = 117
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char = c;code = 99
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = i;code = 105
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char = d;code = 100
char = u;code = 117
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char = ;code = 32
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char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
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char = s;code = 115
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char = o;code = 111
char = x;code = 120
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char = d;code = 100
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
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char = ;code = 32
char = s;code = 115
char = t;code = 116
char = r;code = 114
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char = s;code = 115
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
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char = .;code = 46
result sql = Butyric acid induces apoptosis via oxidative stress in Jurkat T-cells.
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result sql = Reactive oxygen species (ROS) are essential for the induction of T-cell apoptosis by butyric acid, an extracellular metabolite of periodontopathic bacteria. To determine the involvement of oxidative stress in apoptosis pathways, we investigated the contribution of ROS in mitochondrial signaling pathways, death-receptor-initiated signaling pathway, and endoplasmic reticulum stress in butyric-acid-induced T-cell apoptosis. N-acetyl-L-Cysteine (NAC) abrogated mitochondrial injury, cytochrome c, AIF, and Smac release, and Bcl-2 and Bcl-xL suppression and Bax and Bad activation induced by butyric acid. However, the decrease in cFLIP expression by butyric acid was not restored by treatment with NAC; increases in caspase-4 and -10 activities by butyric acid were completely abrogated by NAC. NAC also affected the elevation of GRP78 and CHOP/GADD153 expression by butyric acid. These results suggest that butyric acid is involved in mitochondrial-dysfunction- and endoplasmic reticulum stress-mediated apoptosis in human Jurkat T-cells via a ROS-dependent mechanism.
Publication: J. Dent. Res. 2010 Jul ;89(7)::689-94. :doi: 10.1177/0022034510365456.
Publication Date: 2010 Jul
Study Author(s): Kurita-Ochiai, T;Ochiai, K;
Institution: Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan. [email protected]
Shortcut link to this study:
Publication Date: 2010 Jul
Study Author(s): Kurita-Ochiai, T;Ochiai, K;
Institution: Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan. [email protected]
Shortcut link to this study:
Reactive oxygen species (ROS) are essential for the induction of T-cell apoptosis by butyric acid, an extracellular metabolite of periodontopathic bacteria. To determine the involvement of oxidative stress in apoptosis pathways, we investigated the contribution of ROS in mitochondrial signaling pathways, death-receptor-initiated signaling pathway, and endoplasmic reticulum stress in butyric-acid-induced T-cell apoptosis. N-acetyl-L-Cysteine (NAC) abrogated mitochondrial injury, cytochrome c, AIF, and Smac release, and Bcl-2 and Bcl-xL suppression and Bax and Bad activation induced by butyric acid. However, the decrease in cFLIP expression by butyric acid was not restored by treatment with NAC; increases in caspase-4 and -10 activities by butyric acid were completely abrogated by NAC. NAC also affected the elevation of GRP78 and CHOP/GADD153 expression by butyric acid. These results suggest that butyric acid is involved in mitochondrial-dysfunction- and endoplasmic reticulum stress-mediated apoptosis in human Jurkat T-cells via a ROS-dependent mechanism.
PMID: 20439934
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