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result sql = Solid-state studies of the triclinic (Z' = 2) antiprotozoal drug ternidazole.
Solid-state studies of the triclinic (Z' = 2) antiprotozoal drug ternidazole.
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char = n;code = 110
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char = ;code = 32
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char = s;code = 115
char = ;code = 32
char = m;code = 109
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char = t;code = 116
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = k;code = 107
char = e;code = 101
char = l;code = 108
char = y;code = 121
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char = h;code = 104
char = e;code = 101
char = ;code = 32
char = s;code = 115
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char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = o;code = 111
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result sql = The solid-state properties of antiprotozoal ternidazole (3-(2-methyl-5-nitroimidazol-1-yl)-propan-1-ol) have been studied. Crystals are triclinic in the temperature interval between 100 and 333 K (melting point) with two different molecular conformations present in the asymmetric unit (Z' = 2) and two of each conformer make up a tetramer held together by hydrogen bonding. Its melting enthalpy at 333 K is 25.65 (± 1.29) kJ · mol(-1). Linear plots were obtained for the melting temperature versus pressure (dP/dT = 5.67 (± 0.08) MPa · K(-1)] and the glass transition versus pressure [dP/dT = 7.73 (±1.76) MPa · K(-1)]. No crystalline polymorphism could be detected; thus, the single-crystal structure that has been found is most likely the stable one.

Publication: J Pharm Sci 2011 Jun ;100(6)::2258-66. :doi: 10.1002/jps.22460.
Publication Date: 2011 Jun
Study Author(s): Mahé, Nathalie;Perrin, Marc-Antoine;Barrio, Maria;Nicolaï, Béatrice;Rietveld, Ivo B;Tamarit, Josep-Lluís;Céolin, René;
Institution: Laboratoire de Chimie Physique (former EA4066), Faculté de Pharmacie, Université Paris Descartes, 75006 Paris, France.
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The solid-state properties of antiprotozoal ternidazole (3-(2-methyl-5-nitroimidazol-1-yl)-propan-1-ol) have been studied. Crystals are triclinic in the temperature interval between 100 and 333 K (melting point) with two different molecular conformations present in the asymmetric unit (Z' = 2) and two of each conformer make up a tetramer held together by hydrogen bonding. Its melting enthalpy at 333 K is 25.65 (± 1.29) kJ · mol(-1). Linear plots were obtained for the melting temperature versus pressure (dP/dT = 5.67 (± 0.08) MPa · K(-1)] and the glass transition versus pressure [dP/dT = 7.73 (±1.76) MPa · K(-1)]. No crystalline polymorphism could be detected; thus, the single-crystal structure that has been found is most likely the stable one.
PMID: 21246558

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