char = S;code = 83 char = o;code = 111 char = l;code = 108 char = i;code = 105 char = d;code = 100 char = -;code = 45 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = i;code = 105 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = i;code = 105 char = c;code = 99 char = l;code = 108 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = (;code = 40 char = Z;code = 90 char = ';code = 39 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = 2;code = 50 char = );code = 41 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = t;code = 116 char = o;code = 111 char = z;code = 122 char = o;code = 111 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = d;code = 100 char = r;code = 114 char = u;code = 117 char = g;code = 103 char = ;code = 32 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = n;code = 110 char = i;code = 105 char = d;code = 100 char = a;code = 97 char = z;code = 122 char = o;code = 111 char = l;code = 108 char = e;code = 101 char = .;code = 46 result sql = Solid-state studies of the triclinic (Z' = 2) antiprotozoal drug ternidazole.
Solid-state studies of the triclinic (Z' = 2) antiprotozoal drug ternidazole.char = T;code = 84 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = o;code = 111 char = l;code = 108 char = i;code = 105 char = d;code = 100 char = -;code = 45 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = t;code = 116 char = o;code = 111 char = z;code = 122 char = o;code = 111 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = n;code = 110 char = i;code = 105 char = d;code = 100 char = a;code = 97 char = z;code = 122 char = o;code = 111 char = l;code = 108 char = e;code = 101 char = ;code = 32 char = (;code = 40 char = 3;code = 51 char = -;code = 45 char = (;code = 40 char = 2;code = 50 char = -;code = 45 char = m;code = 109 char = e;code = 101 char = t;code = 116 char = h;code = 104 char = y;code = 121 char = l;code = 108 char = -;code = 45 char = 5;code = 53 char = -;code = 45 char = n;code = 110 char = i;code = 105 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = i;code = 105 char = m;code = 109 char = i;code = 105 char = d;code = 100 char = a;code = 97 char = z;code = 122 char = o;code = 111 char = l;code = 108 char = -;code = 45 char = 1;code = 49 char = -;code = 45 char = y;code = 121 char = l;code = 108 char = );code = 41 char = -;code = 45 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = a;code = 97 char = n;code = 110 char = -;code = 45 char = 1;code = 49 char = -;code = 45 char = o;code = 111 char = l;code = 108 char = );code = 41 char = ;code = 32 char = h;code = 104 char = a;code = 97 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = i;code = 105 char = e;code = 101 char = d;code = 100 char = .;code = 46 char = ;code = 32 char = C;code = 67 char = r;code = 114 char = y;code = 121 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = l;code = 108 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = i;code = 105 char = c;code = 99 char = l;code = 108 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = e;code = 101 char = m;code = 109 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = t;code = 116 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = 1;code = 49 char = 0;code = 48 char = 0;code = 48 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = 3;code = 51 char = 3;code = 51 char = 3;code = 51 char = ;code = 32 char = K;code = 75 char = ;code = 32 char = (;code = 40 char = m;code = 109 char = e;code = 101 char = l;code = 108 char = t;code = 116 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = p;code = 112 char = o;code = 111 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = );code = 41 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = t;code = 116 char = w;code = 119 char = o;code = 111 char = ;code = 32 char = d;code = 100 char = i;code = 105 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = l;code = 108 char = e;code = 101 char = c;code = 99 char = u;code = 117 char = l;code = 108 char = a;code = 97 char = r;code = 114 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = m;code = 109 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = s;code = 115 char = y;code = 121 char = m;code = 109 char = m;code = 109 char = e;code = 101 char = t;code = 116 char = r;code = 114 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = u;code = 117 char = n;code = 110 char = i;code = 105 char = t;code = 116 char = ;code = 32 char = (;code = 40 char = Z;code = 90 char = ';code = 39 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = 2;code = 50 char = );code = 41 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = w;code = 119 char = o;code = 111 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = e;code = 101 char = a;code = 97 char = c;code = 99 char = h;code = 104 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = m;code = 109 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = m;code = 109 char = a;code = 97 char = k;code = 107 char = e;code = 101 char = ;code = 32 char = u;code = 117 char = p;code = 112 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = t;code = 116 char = e;code = 101 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = m;code = 109 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = h;code = 104 char = e;code = 101 char = l;code = 108 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = g;code = 103 char = e;code = 101 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = b;code = 98 char = y;code = 121 char = ;code = 32 char = h;code = 104 char = y;code = 121 char = d;code = 100 char = r;code = 114 char = o;code = 111 char = g;code = 103 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = b;code = 98 char = o;code = 111 char = n;code = 110 char = d;code = 100 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = .;code = 46 char = ;code = 32 char = I;code = 73 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = m;code = 109 char = e;code = 101 char = l;code = 108 char = t;code = 116 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = l;code = 108 char = p;code = 112 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = 3;code = 51 char = 3;code = 51 char = 3;code = 51 char = ;code = 32 char = K;code = 75 char = ;code = 32 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = 2;code = 50 char = 5;code = 53 char = .;code = 46 char = 6;code = 54 char = 5;code = 53 char = ;code = 32 char = (;code = 40 char = &;code = 38 char = #;code = 35 char = 1;code = 49 char = 7;code = 55 char = 7;code = 55 char = ;;code = 59 char = ;code = 32 char = 1;code = 49 char = .;code = 46 char = 2;code = 50 char = 9;code = 57 char = );code = 41 char = ;code = 32 char = k;code = 107 char = J;code = 74 char = ;code = 32 char = &;code = 38 char = #;code = 35 char = 1;code = 49 char = 8;code = 56 char = 3;code = 51 char = ;;code = 59 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = l;code = 108 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = .;code = 46 char = ;code = 32 char = L;code = 76 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = a;code = 97 char = r;code = 114 char = ;code = 32 char = p;code = 112 char = l;code = 108 char = o;code = 111 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = b;code = 98 char = t;code = 116 char = a;code = 97 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = m;code = 109 char = e;code = 101 char = l;code = 108 char = t;code = 116 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = t;code = 116 char = e;code = 101 char = m;code = 109 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = (;code = 40 char = d;code = 100 char = P;code = 80 char = /;code = 47 char = d;code = 100 char = T;code = 84 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = 5;code = 53 char = .;code = 46 char = 6;code = 54 char = 7;code = 55 char = ;code = 32 char = (;code = 40 char = &;code = 38 char = #;code = 35 char = 1;code = 49 char = 7;code = 55 char = 7;code = 55 char = ;;code = 59 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 8;code = 56 char = );code = 41 char = ;code = 32 char = M;code = 77 char = P;code = 80 char = a;code = 97 char = ;code = 32 char = &;code = 38 char = #;code = 35 char = 1;code = 49 char = 8;code = 56 char = 3;code = 51 char = ;;code = 59 char = ;code = 32 char = K;code = 75 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ];code = 93 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = g;code = 103 char = l;code = 108 char = a;code = 97 char = s;code = 115 char = s;code = 115 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = n;code = 110 char = s;code = 115 char = i;code = 105 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = [;code = 91 char = d;code = 100 char = P;code = 80 char = /;code = 47 char = d;code = 100 char = T;code = 84 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = 7;code = 55 char = .;code = 46 char = 7;code = 55 char = 3;code = 51 char = ;code = 32 char = (;code = 40 char = &;code = 38 char = #;code = 35 char = 1;code = 49 char = 7;code = 55 char = 7;code = 55 char = ;;code = 59 char = 1;code = 49 char = .;code = 46 char = 7;code = 55 char = 6;code = 54 char = );code = 41 char = ;code = 32 char = M;code = 77 char = P;code = 80 char = a;code = 97 char = ;code = 32 char = &;code = 38 char = #;code = 35 char = 1;code = 49 char = 8;code = 56 char = 3;code = 51 char = ;;code = 59 char = ;code = 32 char = K;code = 75 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ];code = 93 char = .;code = 46 char = ;code = 32 char = N;code = 78 char = o;code = 111 char = ;code = 32 char = c;code = 99 char = r;code = 114 char = y;code = 121 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = l;code = 108 char = l;code = 108 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = o;code = 111 char = l;code = 108 char = y;code = 121 char = m;code = 109 char = o;code = 111 char = r;code = 114 char = p;code = 112 char = h;code = 104 char = i;code = 105 char = s;code = 115 char = m;code = 109 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = u;code = 117 char = l;code = 108 char = d;code = 100 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = t;code = 116 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;;code = 59 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = u;code = 117 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = l;code = 108 char = e;code = 101 char = -;code = 45 char = c;code = 99 char = r;code = 114 char = y;code = 121 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = u;code = 117 char = c;code = 99 char = t;code = 116 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = h;code = 104 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = u;code = 117 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = l;code = 108 char = i;code = 105 char = k;code = 107 char = e;code = 101 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = b;code = 98 char = l;code = 108 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = .;code = 46 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 result sql = The solid-state properties of antiprotozoal ternidazole (3-(2-methyl-5-nitroimidazol-1-yl)-propan-1-ol) have been studied. Crystals are triclinic in the temperature interval between 100 and 333 K (melting point) with two different molecular conformations present in the asymmetric unit (Z' = 2) and two of each conformer make up a tetramer held together by hydrogen bonding. Its melting enthalpy at 333 K is 25.65 (± 1.29) kJ · mol(-1). Linear plots were obtained for the melting temperature versus pressure (dP/dT = 5.67 (± 0.08) MPa · K(-1)] and the glass transition versus pressure [dP/dT = 7.73 (±1.76) MPa · K(-1)]. No crystalline polymorphism could be detected; thus, the single-crystal structure that has been found is most likely the stable one.
Publication: J Pharm Sci 2011 Jun ;100(6)::2258-66. :doi: 10.1002/jps.22460.
Publication Date: 2011 Jun
Study Author(s): Mahé, Nathalie;Perrin, Marc-Antoine;Barrio, Maria;Nicolaï, Béatrice;Rietveld, Ivo B;Tamarit, Josep-Lluís;Céolin, René;
Institution: Laboratoire de Chimie Physique (former EA4066), Faculté de Pharmacie, Université Paris Descartes, 75006 Paris, France.
Shortcut link to this study:
The solid-state properties of antiprotozoal ternidazole (3-(2-methyl-5-nitroimidazol-1-yl)-propan-1-ol) have been studied. Crystals are triclinic in the temperature interval between 100 and 333 K (melting point) with two different molecular conformations present in the asymmetric unit (Z' = 2) and two of each conformer make up a tetramer held together by hydrogen bonding. Its melting enthalpy at 333 K is 25.65 (± 1.29) kJ · mol(-1). Linear plots were obtained for the melting temperature versus pressure (dP/dT = 5.67 (± 0.08) MPa · K(-1)] and the glass transition versus pressure [dP/dT = 7.73 (±1.76) MPa · K(-1)]. No crystalline polymorphism could be detected; thus, the single-crystal structure that has been found is most likely the stable one.
PMID: 21246558