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char = i;code = 105
char = o;code = 111
char = g;code = 103
char = e;code = 101
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char = v;code = 118
char = i;code = 105
char = t;code = 116
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char = f;code = 102
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char = G;code = 71
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char = n;code = 110
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char = r;code = 114
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char = s;code = 115
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char = g;code = 103
char = e;code = 101
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char = e;code = 101
char = x;code = 120
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char = t;code = 116
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char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = .;code = 46
result sql = Anti-angiogenic activity of Gynura segetum leaf extracts and its fractions.
Anti-angiogenic activity of Gynura segetum leaf extracts and its fractions.
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char = b;code = 98
char = >;code = 62
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char = T;code = 84
char = H;code = 72
char = N;code = 78
char = O;code = 79
char = P;code = 80
char = H;code = 72
char = A;code = 65
char = R;code = 82
char = M;code = 77
char = A;code = 65
char = C;code = 67
char = O;code = 79
char = L;code = 76
char = O;code = 79
char = G;code = 71
char = I;code = 73
char = C;code = 67
char = A;code = 65
char = L;code = 76
char = ;code = 32
char = R;code = 82
char = E;code = 69
char = L;code = 76
char = E;code = 69
char = V;code = 86
char = A;code = 65
char = N;code = 78
char = C;code = 67
char = E;code = 69
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
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char = g;code = 103
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char = a;code = 97
char = l;code = 108
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char = r;code = 114
char = o;code = 111
char = p;code = 112
char = e;code = 101
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char = e;code = 101
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char = e;code = 101
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char = p;code = 112
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char = l;code = 108
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char = <;code = 60
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char = <;code = 60
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char = >;code = 62
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char = O;code = 79
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char = s;code = 115
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char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = e;code = 101
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char = c;code = 99
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char = e;code = 101
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char = r;code = 114
char = a;code = 97
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char = t;code = 116
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char = <;code = 60
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char = <;code = 60
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char = I;code = 73
char = A;code = 65
char = L;code = 76
char = S;code = 83
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char = A;code = 65
char = N;code = 78
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char = <;code = 60
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char = s;code = 115
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char = s;code = 115
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char = s;code = 115
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char = <;code = 60
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char = R;code = 82
char = E;code = 69
char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
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char = e;code = 101
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char = ;code = 32
char = a;code = 97
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char = e;code = 101
char = ;code = 32
char = f;code = 102
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char = r;code = 114
char = ;code = 32
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char = t;code = 116
char = e;code = 101
char = c;code = 99
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char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = a;code = 97
char = g;code = 103
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = t;code = 116
char = ;code = 32
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char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = .;code = 46
result sql = ETHNOPHARMACOLOGICAL RELEVANCE : Gynura segetum is a popular medicinal plant in Indonesia and Malaysia, known to possess various medicinal properties especially for treatment of cancer, diabetes and hypertension.

AIM OF THE STUDY : This study was carried out to evaluate the anti-angiogenic effect of Gynura segetum leaves extracts and its fractions. The chemical compositions of the active extracts were also determined.

MATERIALS AND METHODS : The anti-angiogenic activity of Gynura segetum leaves extracts and its fractions was evaluated in vivo using the chick embryo chorioallantoic membrane (CAM) assay. Gas chromatography-mass spectrometry (GC-MS) analysis was carried out to identify the chemical compositions of the active extracts.

RESULTS : The CAM treated with Gynura segetum leaves extracts and its fractions (100μg/disc) showed a significantly greater anti-angiogenic effect compared to the positive control suramin (50μg/disc). Chemical analysis of the active extracts from the leaves of Gynura segetum yielded nine known compounds: undecane (1), neophytadine (2), hexadecanoic acid, methyl ester (3), 9,12-octadecadienoic acid, methyl ester (4), 9,12,15-octadecatrienoic acid, methyl ester (5), phytol (6), tetradecanal (7), octadecanoic acid, methyl ester (8) and γ-sitosterol (9).

CONCLUSIONS : These results suggested that Gynura segetum has anti-angiogenic activity. The plant may be used as a potential source for protection against cancer.

Publication: J Ethnopharmacol 2011 Mar 24 ;134(2)::221-7. :doi: 10.1016/j.jep.2010.12.007.
Publication Date: 2011 Mar 24
Study Author(s): Seow, Lay-Jing;Beh, Hooi-Kheng;Majid, Amin Malik Shah Abdul;Murugaiyah, Vikneswaran;Ismail, Norhayati;Asmawi, Mohd Zaini;
Institution: School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia. [email protected]
Shortcut link to this study:
ETHNOPHARMACOLOGICAL RELEVANCE : Gynura segetum is a popular medicinal plant in Indonesia and Malaysia, known to possess various medicinal properties especially for treatment of cancer, diabetes and hypertension.

AIM OF THE STUDY : This study was carried out to evaluate the anti-angiogenic effect of Gynura segetum leaves extracts and its fractions. The chemical compositions of the active extracts were also determined.

MATERIALS AND METHODS : The anti-angiogenic activity of Gynura segetum leaves extracts and its fractions was evaluated in vivo using the chick embryo chorioallantoic membrane (CAM) assay. Gas chromatography-mass spectrometry (GC-MS) analysis was carried out to identify the chemical compositions of the active extracts.

RESULTS : The CAM treated with Gynura segetum leaves extracts and its fractions (100μg/disc) showed a significantly greater anti-angiogenic effect compared to the positive control suramin (50μg/disc). Chemical analysis of the active extracts from the leaves of Gynura segetum yielded nine known compounds: undecane (1), neophytadine (2), hexadecanoic acid, methyl ester (3), 9,12-octadecadienoic acid, methyl ester (4), 9,12,15-octadecatrienoic acid, methyl ester (5), phytol (6), tetradecanal (7), octadecanoic acid, methyl ester (8) and γ-sitosterol (9).

CONCLUSIONS : These results suggested that Gynura segetum has anti-angiogenic activity. The plant may be used as a potential source for protection against cancer.
PMID: 21167271

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