Vitamin D deficiency is associated with type 2 diabetes mellitus in HIV infection.

Publication: AIDS (London, England)
Publication Date: 2011
Study Author(s): Szep, Zsofia;Guaraldi, Giovanni;Shah, Samir S;Lo Re, Vincent;Ratcliffe, Sarah J;Orlando, Gabriella;Carli, Federica;Rossi, Rosario;Rochira, Vincenzo;Tebas, Pablo;
Institution: Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, USA. zsofia.szep@uphs.upenn.edu
Shortcut link to this study: http://science.naturalnews.com/pubmed/21178753.html
BACKGROUND : Metabolic complications, including type 2 Diabetes mellitus and metabolic syndrome, are increasingly recognized among HIV-infected individuals. Low Vitamin D levels increase the risk of type 2 diabetes mellitus, and Vitamin D supplementation has been shown to decrease the risk of type 2 diabetes mellitus in patients without HIV infection.

OBJECTIVES : The primary objective was to determine whether vitamin D deficiency (serum 25-hyrdoxyvitamin D <20 ng/ml) was associated with type 2 Diabetes mellitus among HIV-infected patients. Our secondary objective was to determine whether vitamin D deficiency was associated with metabolic syndrome in HIV.

METHODS : We conducted a cross-sectional study among participants enrolled in the prospective Modena (Italy) HIV Metabolic Clinic Cohort. Clinical and laboratory data, including history of type 2 diabetes mellitus, fasting blood glucose, components of metabolic syndrome, and 25-hydroxyvitamin D levels, were obtained for all participants.

RESULTS : After adjusting for vitamin D supplementation, sex, age, body mass index, and Hepatitis C virus co-infection, vitamin D deficiency was associated with type 2 diabetes mellitus [adjusted odds ratio (OR) 1.85; 95% confidence interval (CI) 1.03-3.32; P = 0.038]. The association between vitamin D deficiency and metabolic syndrome was not significant after adjusting for vitamin D supplementation, sex, age and Body Mass Index (adjusted OR 1.32; 95% CI 1.00-1.75; P = 0.053).

CONCLUSIONS : Our study demonstrates an association between vitamin D deficiency and type 2 Diabetes mellitus. Clinical trials are needed to better characterize the association between vitamin D deficiency and type 2 diabetes mellitus in HIV infection and to evaluate whether vitamin D is able to prevent or delay the onset of type 2 diabetes mellitus.
PMID: 21178753

Have comments? Post them here:

comments powered by Disqus

Get breaking news about nutritional cures, dangerous chemicals, superfoods and more.

Subscribe to the FREE Natural News email newsletter. Your privacy is protected.