|
|
char = G;code = 71
char = e;code = 101
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char = i;code = 105
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char = i;code = 105
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char = r;code = 114
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char = s;code = 115
char = t;code = 116
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char = t;code = 116
char = e;code = 101
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char = n;code = 110
char = c;code = 99
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char = g;code = 103
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char = h;code = 104
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = t;code = 116
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = c;code = 99
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char = ;code = 32
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char = o;code = 111
char = p;code = 112
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char = i;code = 105
char = s;code = 115
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char = p;code = 112
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = w;code = 119
char = a;code = 97
char = y;code = 121
char = s;code = 115
char = .;code = 46
result sql = Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways.
Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways.char = T;code = 84
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char = e;code = 101
char = ;code = 32
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char = r;code = 114
char = o;code = 111
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char = r;code = 114
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char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
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char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
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char = s;code = 115
char = ;code = 32
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char = s;code = 115
char = s;code = 115
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = w;code = 119
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char = e;code = 101
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char = c;code = 99
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char = l;code = 108
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char = y;code = 121
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char = r;code = 114
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char = .;code = 46
char = ;code = 32
char = H;code = 72
char = e;code = 101
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char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = o;code = 111
char = l;code = 108
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = a;code = 97
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char = l;code = 108
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char = c;code = 99
char = c;code = 99
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char = r;code = 114
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char = n;code = 110
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char = m;code = 109
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char = o;code = 111
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char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = i;code = 105
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char = l;code = 108
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char = a;code = 97
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char = r;code = 114
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char = ;code = 32
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char = g;code = 103
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char = P;code = 80
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char = G;code = 71
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char = a;code = 97
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char = o;code = 111
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char = m;code = 109
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char = l;code = 108
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char = ;code = 32
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char = d;code = 100
char = ;code = 32
char = B;code = 66
char = c;code = 99
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char = l;code = 108
char = y;code = 121
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char = p;code = 112
char = r;code = 114
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char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = P;code = 80
char = C;code = 67
char = -;code = 45
char = 3;code = 51
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = i;code = 105
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char = i;code = 105
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char = F;code = 70
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char = e;code = 101
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result sql = The progression of prostate cancer is associated with escape from cell cycle arrest and apoptosis under androgen-depleted conditions. Here, we found that geraniol, a naturally occurring monoterpene, induces cell cycle arrest and apoptosis in cultured cells and tumor grafted mice using PC-3 prostate cancer cells. Geraniol modulated the expression of various cell cycle regulators and Bcl-2 family proteins in PC-3 cells in vitro and in vivo. Furthermore, we showed that the combination of sub-optimal doses of geraniol and docetaxel noticeably suppresses prostate cancer growth in cultured cells and tumor xenograft mice. Therefore, our findings provide insight into unraveling the mechanisms underlying escape from cell cycle arrest and apoptosis and developing therapeutic strategies against prostate cancer.
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result sql = Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways.
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result sql = The progression of prostate cancer is associated with escape from cell cycle arrest and apoptosis under androgen-depleted conditions. Here, we found that geraniol, a naturally occurring monoterpene, induces cell cycle arrest and apoptosis in cultured cells and tumor grafted mice using PC-3 prostate cancer cells. Geraniol modulated the expression of various cell cycle regulators and Bcl-2 family proteins in PC-3 cells in vitro and in vivo. Furthermore, we showed that the combination of sub-optimal doses of geraniol and docetaxel noticeably suppresses prostate cancer growth in cultured cells and tumor xenograft mice. Therefore, our findings provide insight into unraveling the mechanisms underlying escape from cell cycle arrest and apoptosis and developing therapeutic strategies against prostate cancer.
Publication: Biochem. Biophys. Res. Commun. 2011 Apr 1 ;407(1)::129-34. :doi: 10.1016/j.bbrc.2011.02.124.
Publication Date: 2011 Apr 1
Study Author(s): Kim, Su-Hwa;Bae, Hyun Cheol;Park, Eun-Jung;Lee, Chae Ryun;Kim, Byung-Joo;Lee, Sanghoon;Park, Hyun Ho;Kim, Sung-Joon;So, Insuk;Kim, Tae Woo;Jeon, Ju-Hong;
Institution: Department of Physiology, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea.
Shortcut link to this study:
Publication Date: 2011 Apr 1
Study Author(s): Kim, Su-Hwa;Bae, Hyun Cheol;Park, Eun-Jung;Lee, Chae Ryun;Kim, Byung-Joo;Lee, Sanghoon;Park, Hyun Ho;Kim, Sung-Joon;So, Insuk;Kim, Tae Woo;Jeon, Ju-Hong;
Institution: Department of Physiology, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea.
Shortcut link to this study:
The progression of prostate cancer is associated with escape from cell cycle arrest and apoptosis under androgen-depleted conditions. Here, we found that geraniol, a naturally occurring monoterpene, induces cell cycle arrest and apoptosis in cultured cells and tumor grafted mice using PC-3 prostate cancer cells. Geraniol modulated the expression of various cell cycle regulators and Bcl-2 family proteins in PC-3 cells in vitro and in vivo. Furthermore, we showed that the combination of sub-optimal doses of geraniol and docetaxel noticeably suppresses prostate cancer growth in cultured cells and tumor xenograft mice. Therefore, our findings provide insight into unraveling the mechanisms underlying escape from cell cycle arrest and apoptosis and developing therapeutic strategies against prostate cancer.
PMID: 21371438
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