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result sql = A role for sleep disruption in cognitive impairment in children with epilepsy.
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result sql = Early-onset epilepsy is associated with a poor cognitive outcome, with the cumulative burden of both ictal and interictal epileptiform discharges likely to contribute significantly. Memory consolidation has been shown to occur during sleep in healthy children, with an associated electroencephalographic signature. This may be disrupted in children with epilepsy, who exhibit a high incidence of sleep disorders, whether directly related to their seizures or as a comorbidity. Conversely, seizure semiology may be influenced by sleep. In this review we present clinical and experimental evidence that suggests that the disruption of sleep architecture by epileptiform discharges may be an important factor contributing to cognitive impairment in children with epilepsy.
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result sql = A role for sleep disruption in cognitive impairment in children with epilepsy.
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char = s;code = 115
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char = n;code = 110
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char = e;code = 101
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char = h;code = 104
char = a;code = 97
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = r;code = 114
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char = p;code = 112
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char = c;code = 99
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char = i;code = 105
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char = t;code = 116
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char = r;code = 114
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char = ;code = 32
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char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = y;code = 121
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char = ;code = 32
char = d;code = 100
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char = d;code = 100
char = ;code = 32
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char = n;code = 110
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = i;code = 105
char = l;code = 108
char = d;code = 100
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char = e;code = 101
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char = ;code = 32
char = w;code = 119
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char = t;code = 116
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char = ;code = 32
char = e;code = 101
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char = i;code = 105
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char = i;code = 105
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char = ;code = 32
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char = ;code = 32
char = h;code = 104
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char = g;code = 103
char = h;code = 104
char = ;code = 32
char = i;code = 105
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char = i;code = 105
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char = ;code = 32
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char = e;code = 101
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char = ;code = 32
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char = i;code = 105
char = s;code = 115
char = o;code = 111
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char = d;code = 100
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char = s;code = 115
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char = ;code = 32
char = w;code = 119
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char = h;code = 104
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char = i;code = 105
char = r;code = 114
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char = ;code = 32
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char = l;code = 108
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char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = i;code = 105
char = r;code = 114
char = ;code = 32
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char = e;code = 101
char = i;code = 105
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char = u;code = 117
char = r;code = 114
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char = ;code = 32
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char = ;code = 32
char = a;code = 97
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = o;code = 111
char = r;code = 114
char = b;code = 98
char = i;code = 105
char = d;code = 100
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = ;code = 32
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char = n;code = 110
char = v;code = 118
char = e;code = 101
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char = s;code = 115
char = e;code = 101
char = l;code = 108
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char = ;code = 32
char = s;code = 115
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char = i;code = 105
char = z;code = 122
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char = e;code = 101
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = m;code = 109
char = i;code = 105
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = y;code = 121
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = b;code = 98
char = e;code = 101
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char = n;code = 110
char = f;code = 102
char = l;code = 108
char = u;code = 117
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = s;code = 115
char = l;code = 108
char = e;code = 101
char = e;code = 101
char = p;code = 112
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = v;code = 118
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char = e;code = 101
char = w;code = 119
char = ;code = 32
char = w;code = 119
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char = p;code = 112
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char = e;code = 101
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char = t;code = 116
char = ;code = 32
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char = l;code = 108
char = i;code = 105
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char = d;code = 100
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char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = ;code = 32
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char = ;code = 32
char = e;code = 101
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char = i;code = 105
char = l;code = 108
char = e;code = 101
char = p;code = 112
char = t;code = 116
char = i;code = 105
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = s;code = 115
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = p;code = 112
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = b;code = 98
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = i;code = 105
char = r;code = 114
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = i;code = 105
char = l;code = 108
char = d;code = 100
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = e;code = 101
char = p;code = 112
char = i;code = 105
char = l;code = 108
char = e;code = 101
char = p;code = 112
char = s;code = 115
char = y;code = 121
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = Early-onset epilepsy is associated with a poor cognitive outcome, with the cumulative burden of both ictal and interictal epileptiform discharges likely to contribute significantly. Memory consolidation has been shown to occur during sleep in healthy children, with an associated electroencephalographic signature. This may be disrupted in children with epilepsy, who exhibit a high incidence of sleep disorders, whether directly related to their seizures or as a comorbidity. Conversely, seizure semiology may be influenced by sleep. In this review we present clinical and experimental evidence that suggests that the disruption of sleep architecture by epileptiform discharges may be an important factor contributing to cognitive impairment in children with epilepsy.
Publication: Epilepsy Behav 2011 Mar ;20(3)::435-40. :doi: 10.1016/j.yebeh.2010.12.047.
Publication Date: 2011 Mar
Study Author(s): Chan, S;Baldeweg, T;Cross, J H;
Institution: Neurosciences Unit, UCL Institute of Child Health, London, UK.
Shortcut link to this study:
Publication Date: 2011 Mar
Study Author(s): Chan, S;Baldeweg, T;Cross, J H;
Institution: Neurosciences Unit, UCL Institute of Child Health, London, UK.
Shortcut link to this study:
Early-onset epilepsy is associated with a poor cognitive outcome, with the cumulative burden of both ictal and interictal epileptiform discharges likely to contribute significantly. Memory consolidation has been shown to occur during sleep in healthy children, with an associated electroencephalographic signature. This may be disrupted in children with epilepsy, who exhibit a high incidence of sleep disorders, whether directly related to their seizures or as a comorbidity. Conversely, seizure semiology may be influenced by sleep. In this review we present clinical and experimental evidence that suggests that the disruption of sleep architecture by epileptiform discharges may be an important factor contributing to cognitive impairment in children with epilepsy.
PMID: 21310668
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