char = [;code = 91
char = M;code = 77
char = e;code = 101
char = t;code = 116
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = n;code = 110
char = -;code = 45
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = o;code = 111
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = t;code = 116
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = s;code = 115
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = s;code = 115
char = :;code = 58
char = ;code = 32
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = s;code = 115
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = p;code = 112
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = A;code = 65
char = 2;code = 50
char = /;code = 47
char = l;code = 108
char = y;code = 121
char = s;code = 115
char = o;code = 111
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = s;code = 115
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = d;code = 100
char = y;code = 121
char = l;code = 108
char = c;code = 99
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = p;code = 112
char = o;code = 111
char = a;code = 97
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = w;code = 119
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = ];code = 93
char = .;code = 46
result sql = [Metformin prevents non-alcoholic fatty liver disease in rats: role of phospholipase A2/lysophosphatidylcholine lipoapoptosis pathway in hepatocytes].

[Metformin prevents non-alcoholic fatty liver disease in rats: role of phospholipase A2/lysophosphatidylcholine lipoapoptosis pathway in hepatocytes].

char = <;code = 60
char = b;code = 98
char = >;code = 62
char = O;code = 79
char = B;code = 66
char = J;code = 74
char = E;code = 69
char = C;code = 67
char = T;code = 84
char = I;code = 73
char = V;code = 86
char = E;code = 69
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = T;code = 84
char = o;code = 111
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = v;code = 118
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = g;code = 103
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = n;code = 110
char = -;code = 45
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = o;code = 111
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = t;code = 116
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = s;code = 115
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = N;code = 78
char = A;code = 65
char = F;code = 70
char = L;code = 76
char = D;code = 68
char = );code = 41
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = s;code = 115
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = p;code = 112
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = A;code = 65
char = 2;code = 50
char = /;code = 47
char = l;code = 108
char = y;code = 121
char = s;code = 115
char = o;code = 111
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = s;code = 115
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = d;code = 100
char = y;code = 121
char = l;code = 108
char = c;code = 99
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = w;code = 119
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = p;code = 112
char = o;code = 111
char = a;code = 97
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = N;code = 78
char = A;code = 65
char = F;code = 70
char = L;code = 76
char = D;code = 68
char = ;code = 32
char = m;code = 109
char = o;code = 111
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char = e;code = 101
char = l;code = 108
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = -;code = 45
char = f;code = 102
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = e;code = 101
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char = .;code = 46
char = <;code = 60
char = b;code = 98
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char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = M;code = 77
char = E;code = 69
char = T;code = 84
char = H;code = 72
char = O;code = 79
char = D;code = 68
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = M;code = 77
char = a;code = 97
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = S;code = 83
char = D;code = 68
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = n;code = 110
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 3;code = 51
char = 6;code = 54
char = );code = 41
char = ;code = 32
char = w;code = 119
char = e;code = 101
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char = e;code = 101
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = o;code = 111
char = m;code = 109
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = e;code = 101
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = 1;code = 49
char = 2;code = 50
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = e;code = 101
char = a;code = 97
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = t;code = 116
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = d;code = 100
char = r;code = 114
char = u;code = 117
char = g;code = 103
char = s;code = 115
char = :;code = 58
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = I;code = 73
char = :;code = 58
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = d;code = 100
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = e;code = 101
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char = ,;code = 44
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = I;code = 73
char = I;code = 73
char = :;code = 58
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = -;code = 45
char = f;code = 102
char = a;code = 97
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char = ;code = 32
char = d;code = 100
char = i;code = 105
char = e;code = 101
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char = ,;code = 44
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = I;code = 73
char = I;code = 73
char = I;code = 73
char = :;code = 58
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = -;code = 45
char = f;code = 102
char = a;code = 97
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char = ;code = 32
char = d;code = 100
char = i;code = 105
char = e;code = 101
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = f;code = 102
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char = r;code = 114
char = m;code = 109
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char = n;code = 110
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = e;code = 101
char = n;code = 110
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char = w;code = 119
char = e;code = 101
char = e;code = 101
char = k;code = 107
char = s;code = 115
char = ;code = 32
char = l;code = 108
char = a;code = 97
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char = ;code = 32
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char = w;code = 119
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char = e;code = 101
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char = a;code = 97
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char = f;code = 102
char = i;code = 105
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char = d;code = 100
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char = t;code = 116
char = h;code = 104
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char = i;code = 105
char = r;code = 114
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char = b;code = 98
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char = w;code = 119
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = l;code = 108
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char = v;code = 118
char = e;code = 101
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char = w;code = 119
char = e;code = 101
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = t;code = 116
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = o;code = 111
char = b;code = 98
char = t;code = 116
char = a;code = 97
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char = n;code = 110
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char = d;code = 100
char = ,;code = 44
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = r;code = 114
char = u;code = 117
char = m;code = 109
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char = l;code = 108
char = i;code = 105
char = p;code = 112
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char = d;code = 100
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char = m;code = 109
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char = i;code = 105
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char = u;code = 117
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char = i;code = 105
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char = r;code = 114
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char = s;code = 115
char = t;code = 116
char = a;code = 97
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char = c;code = 99
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char = i;code = 105
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char = t;code = 116
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char = p;code = 112
char = h;code = 104
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char = o;code = 111
char = l;code = 108
char = i;code = 105
char = p;code = 112
char = a;code = 97
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char = e;code = 101
char = ;code = 32
char = A;code = 65
char = 2;code = 50
char = ;code = 32
char = (;code = 40
char = s;code = 115
char = P;code = 80
char = L;code = 76
char = A;code = 65
char = 2;code = 50
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = l;code = 108
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char = (;code = 40
char = L;code = 76
char = P;code = 80
char = C;code = 67
char = );code = 41
char = ;code = 32
char = l;code = 108
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char = v;code = 118
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char = d;code = 100
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char = o;code = 111
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char = a;code = 97
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char = a;code = 97
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char = m;code = 109
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char = a;code = 97
char = s;code = 115
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = .;code = 46
char = ;code = 32
char = P;code = 80
char = h;code = 104
char = o;code = 111
char = s;code = 115
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = p;code = 112
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = A;code = 65
char = 2;code = 50
char = ;code = 32
char = m;code = 109
char = R;code = 82
char = N;code = 78
char = A;code = 65
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = q;code = 113
char = u;code = 117
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = c;code = 99
char = r;code = 114
char = i;code = 105
char = p;code = 112
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = -;code = 45
char = p;code = 112
char = o;code = 111
char = l;code = 108
char = y;code = 121
char = m;code = 109
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = i;code = 105
char = n;code = 110
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char = r;code = 114
char = e;code = 101
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = (;code = 40
char = R;code = 82
char = T;code = 84
char = -;code = 45
char = P;code = 80
char = C;code = 67
char = R;code = 82
char = );code = 41
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = d;code = 100
char = d;code = 100
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = i;code = 105
char = s;code = 115
char = s;code = 115
char = u;code = 117
char = e;code = 101
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = y;code = 121
char = z;code = 122
char = e;code = 101
char = d;code = 100
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = R;code = 82
char = E;code = 69
char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = C;code = 67
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = d;code = 100
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = t;code = 116
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = ';code = 39
char = s;code = 115
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = t;code = 116
char = ;code = 32
char = (;code = 40
char = g;code = 103
char = );code = 41
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = 6;code = 54
char = .;code = 46
char = 9;code = 57
char = 2;code = 50
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 2;code = 50
char = .;code = 46
char = 4;code = 52
char = 9;code = 57
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char = v;code = 118
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = 1;code = 49
char = 2;code = 50
char = .;code = 46
char = 1;code = 49
char = 6;code = 54
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 8;code = 56
char = 2;code = 50
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = (;code = 40
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 3;code = 51
char = 4;code = 52
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 0;code = 48
char = 4;code = 52
char = ;code = 32
char = v;code = 118
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 2;code = 50
char = 6;code = 54
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 0;code = 48
char = 2;code = 50
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = r;code = 114
char = u;code = 117
char = m;code = 109
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char = a;code = 97
char = l;code = 108
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = U;code = 85
char = /;code = 47
char = L;code = 76
char = );code = 41
char = ;code = 32
char = (;code = 40
char = 4;code = 52
char = 5;code = 53
char = .;code = 46
char = 4;code = 52
char = 3;code = 51
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char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 9;code = 57
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char = 7;code = 55
char = 3;code = 51
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char = v;code = 118
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = 2;code = 50
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char = .;code = 46
char = 4;code = 52
char = 2;code = 50
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char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 6;code = 54
char = .;code = 46
char = 7;code = 55
char = 3;code = 51
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = g;code = 103
char = l;code = 108
char = y;code = 121
char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = d;code = 100
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = m;code = 109
char = m;code = 109
char = o;code = 111
char = l;code = 108
char = /;code = 47
char = L;code = 76
char = );code = 41
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = .;code = 46
char = 2;code = 50
char = 2;code = 50
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
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char = 2;code = 50
char = 4;code = 52
char = ;code = 32
char = v;code = 118
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char = .;code = 46
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char = 0;code = 48
char = .;code = 46
char = 8;code = 56
char = 5;code = 53
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char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 1;code = 49
char = 9;code = 57
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char = ,;code = 44
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = o;code = 111
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char = e;code = 101
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = (;code = 40
char = m;code = 109
char = m;code = 109
char = o;code = 111
char = l;code = 108
char = /;code = 47
char = L;code = 76
char = );code = 41
char = ;code = 32
char = (;code = 40
char = 2;code = 50
char = .;code = 46
char = 0;code = 48
char = 0;code = 48
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
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char = ;;code = 59
char = ;code = 32
char = 0;code = 48
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char = 3;code = 51
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char = v;code = 118
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char = 1;code = 49
char = .;code = 46
char = 4;code = 52
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char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 3;code = 51
char = 3;code = 51
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
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char = a;code = 97
char = );code = 41
char = ;code = 32
char = (;code = 40
char = m;code = 109
char = m;code = 109
char = o;code = 111
char = l;code = 108
char = /;code = 47
char = L;code = 76
char = );code = 41
char = ;code = 32
char = (;code = 40
char = 7;code = 55
char = 4;code = 52
char = 3;code = 51
char = .;code = 46
char = 8;code = 56
char = 6;code = 54
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
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char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 3;code = 51
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char = 1;code = 49
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char = v;code = 118
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char = ;code = 32
char = 6;code = 54
char = 4;code = 52
char = 8;code = 56
char = .;code = 46
char = 4;code = 52
char = 2;code = 50
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char = &;code = 38
char = #;code = 35
char = 1;code = 49
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char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 7;code = 55
char = 8;code = 56
char = .;code = 46
char = 8;code = 56
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char = );code = 41
char = ,;code = 44
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char = l;code = 108
char = o;code = 111
char = w;code = 119
char = -;code = 45
char = d;code = 100
char = e;code = 101
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char = s;code = 115
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char = t;code = 116
char = y;code = 121
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char = p;code = 112
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
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char = m;code = 109
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char = /;code = 47
char = L;code = 76
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char = 1;code = 49
char = .;code = 46
char = 3;code = 51
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char = 1;code = 49
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char = m;code = 109
char = m;code = 109
char = o;code = 111
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char = /;code = 47
char = L;code = 76
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char = ;code = 32
char = (;code = 40
char = 2;code = 50
char = 2;code = 50
char = .;code = 46
char = 1;code = 49
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char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
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char = 7;code = 55
char = ;;code = 59
char = ;code = 32
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char = 8;code = 56
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char = &;code = 38
char = #;code = 35
char = 1;code = 49
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char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 5;code = 53
char = .;code = 46
char = 3;code = 51
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char = ,;code = 44
char = ;code = 32
char = i;code = 105
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char = u;code = 117
char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = r;code = 114
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char = s;code = 115
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = a;code = 97
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char = c;code = 99
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = x;code = 120
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char = 5;code = 53
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char = 1;code = 49
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char = &;code = 38
char = #;code = 35
char = 1;code = 49
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char = 7;code = 55
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char = ;code = 32
char = 1;code = 49
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char = 4;code = 52
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char = v;code = 118
char = s;code = 115
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char = 3;code = 51
char = .;code = 46
char = 5;code = 53
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char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 9;code = 57
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char = );code = 41
char = ,;code = 44
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = e;code = 101
char = e;code = 101
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char = f;code = 102
char = a;code = 97
char = t;code = 116
char = t;code = 116
char = y;code = 121
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char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = (;code = 40
char = m;code = 109
char = E;code = 69
char = q;code = 113
char = /;code = 47
char = L;code = 76
char = );code = 41
char = ;code = 32
char = (;code = 40
char = 0;code = 48
char = .;code = 46
char = 5;code = 53
char = 7;code = 55
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
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char = v;code = 118
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char = 3;code = 51
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char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
char = .;code = 46
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char = 7;code = 55
char = );code = 41
char = ,;code = 44
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char = L;code = 76
char = A;code = 65
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char = [;code = 91
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char = 1;code = 49
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char = 7;code = 55
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char = 0;code = 48
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char = 0;code = 48
char = 1;code = 49
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char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 9;code = 57
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char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
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char = );code = 41
char = ,;code = 44
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char = l;code = 108
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char = o;code = 111
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char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = c;code = 99
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char = l;code = 108
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char = n;code = 110
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char = #;code = 35
char = 1;code = 49
char = 8;code = 56
char = 1;code = 49
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char = m;code = 109
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char = /;code = 47
char = L;code = 76
char = );code = 41
char = ;code = 32
char = (;code = 40
char = 7;code = 55
char = 0;code = 48
char = 7;code = 55
char = .;code = 46
char = 2;code = 50
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char = &;code = 38
char = #;code = 35
char = 1;code = 49
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char = 7;code = 55
char = ;;code = 59
char = ;code = 32
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char = 4;code = 52
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char = 5;code = 53
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char = .;code = 46
char = 8;code = 56
char = 7;code = 55
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
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char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 9;code = 57
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char = 5;code = 53
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char = );code = 41
char = ,;code = 44
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char = l;code = 108
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char = p;code = 112
char = t;code = 116
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char = n;code = 110
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char = p;code = 112
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char = /;code = 47
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char = l;code = 108
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char = (;code = 40
char = 8;code = 56
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char = .;code = 46
char = 0;code = 48
char = 8;code = 56
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 1;code = 49
char = 7;code = 55
char = .;code = 46
char = 7;code = 55
char = 3;code = 51
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char = 6;code = 54
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char = .;code = 46
char = 1;code = 49
char = 1;code = 49
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 1;code = 49
char = 4;code = 52
char = .;code = 46
char = 0;code = 48
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char = ,;code = 44
char = ;code = 32
char = l;code = 108
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char = v;code = 118
char = e;code = 101
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char = t;code = 116
char = r;code = 114
char = i;code = 105
char = g;code = 103
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char = c;code = 99
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char = d;code = 100
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = m;code = 109
char = g;code = 103
char = /;code = 47
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char = );code = 41
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = 3;code = 51
char = .;code = 46
char = 5;code = 53
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char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
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char = 1;code = 49
char = 2;code = 50
char = .;code = 46
char = 0;code = 48
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char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 1;code = 49
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char = 1;code = 49
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char = );code = 41
char = ,;code = 44
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char = c;code = 99
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char = s;code = 115
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char = e;code = 101
char = r;code = 114
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char = l;code = 108
char = ;code = 32
char = (;code = 40
char = m;code = 109
char = g;code = 103
char = /;code = 47
char = g;code = 103
char = );code = 41
char = ;code = 32
char = (;code = 40
char = 2;code = 50
char = .;code = 46
char = 1;code = 49
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char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
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char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
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char = 1;code = 49
char = 5;code = 53
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char = v;code = 118
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char = ;code = 32
char = 1;code = 49
char = .;code = 46
char = 9;code = 57
char = 4;code = 52
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 1;code = 49
char = 2;code = 50
char = );code = 41
char = ;code = 32
char = (;code = 40
char = P;code = 80
char = ;code = 32
char = <;code = 60
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char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 5;code = 53
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char = ;code = 32
char = w;code = 119
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char = r;code = 114
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = t;code = 116
char = l;code = 108
char = y;code = 121
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char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
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char = n;code = 110
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char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
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char = f;code = 102
char = a;code = 97
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char = i;code = 105
char = e;code = 101
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char = r;code = 114
char = o;code = 111
char = u;code = 117
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char = .;code = 46
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char = M;code = 77
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char = e;code = 101
char = o;code = 111
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char = e;code = 101
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char = f;code = 102
char = ;code = 32
char = h;code = 104
char = e;code = 101
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char = a;code = 97
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char = i;code = 105
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char = e;code = 101
char = a;code = 97
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char = o;code = 111
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char = s;code = 115
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char = a;code = 97
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char = ;code = 32
char = s;code = 115
char = i;code = 105
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char = f;code = 102
char = i;code = 105
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char = a;code = 97
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char = t;code = 116
char = l;code = 108
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char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = s;code = 115
char = P;code = 80
char = L;code = 76
char = A;code = 65
char = 2;code = 50
char = ;code = 32
char = m;code = 109
char = R;code = 82
char = N;code = 78
char = A;code = 65
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
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char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
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char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = l;code = 108
char = y;code = 121
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char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = .;code = 46
char = ;code = 32
char = S;code = 83
char = e;code = 101
char = c;code = 99
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char = d;code = 100
char = l;code = 108
char = y;code = 121
char = ,;code = 44
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char = i;code = 105
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char = m;code = 109
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = o;code = 111
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = g;code = 103
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char = d;code = 100
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char = e;code = 101
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char = r;code = 114
char = o;code = 111
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char = p;code = 112
char = ,;code = 44
char = ;code = 32
char = e;code = 101
char = a;code = 97
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char = l;code = 108
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char = t;code = 116
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char = o;code = 111
char = r;code = 114
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char = i;code = 105
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char = a;code = 97
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char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = l;code = 108
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char = a;code = 97
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char = i;code = 105
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char = t;code = 116
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char = g;code = 103
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char = (;code = 40
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char = 4;code = 52
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char = 7;code = 55
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char = 7;code = 55
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char = 7;code = 55
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char = 1;code = 49
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char = a;code = 97
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char = e;code = 101
char = r;code = 114
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = (;code = 40
char = U;code = 85
char = /;code = 47
char = L;code = 76
char = );code = 41
char = ;code = 32
char = (;code = 40
char = 3;code = 51
char = 0;code = 48
char = .;code = 46
char = 4;code = 52
char = 0;code = 48
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char = &;code = 38
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char = .;code = 46
char = 4;code = 52
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char = 7;code = 55
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char = m;code = 109
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char = /;code = 47
char = L;code = 76
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char = ;code = 32
char = (;code = 40
char = 0;code = 48
char = .;code = 46
char = 7;code = 55
char = 5;code = 53
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char = &;code = 38
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char = 1;code = 49
char = 7;code = 55
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char = ;;code = 59
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char = 2;code = 50
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char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
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char = ;code = 32
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char = c;code = 99
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char = l;code = 108
char = e;code = 101
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char = t;code = 116
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char = r;code = 114
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char = l;code = 108
char = ;code = 32
char = (;code = 40
char = m;code = 109
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char = o;code = 111
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char = m;code = 109
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char = 1;code = 49
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char = 1;code = 49
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char = 7;code = 55
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char = 2;code = 50
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char = 1;code = 49
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char = 1;code = 49
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char = 7;code = 55
char = ;;code = 59
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char = 1;code = 49
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char = s;code = 115
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char = 5;code = 53
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char = &;code = 38
char = #;code = 35
char = 1;code = 49
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char = 7;code = 55
char = ;;code = 59
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char = 1;code = 49
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char = 4;code = 52
char = 1;code = 49
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char = v;code = 118
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char = 5;code = 53
char = .;code = 46
char = 1;code = 49
char = 0;code = 48
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char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 1;code = 49
char = .;code = 46
char = 4;code = 52
char = 5;code = 53
char = );code = 41
char = ,;code = 44
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char = s;code = 115
char = P;code = 80
char = L;code = 76
char = A;code = 65
char = 2;code = 50
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char = [;code = 91
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char = #;code = 35
char = 1;code = 49
char = 8;code = 56
char = 1;code = 49
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char = m;code = 109
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char = l;code = 108
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char = m;code = 109
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char = 1;code = 49
char = 8;code = 56
char = 3;code = 51
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char = m;code = 109
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char = );code = 41
char = ];code = 93
char = ;code = 32
char = (;code = 40
char = 0;code = 48
char = .;code = 46
char = 1;code = 49
char = 0;code = 48
char = 1;code = 49
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 0;code = 48
char = 9;code = 57
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char = v;code = 118
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char = .;code = 46
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 1;code = 49
char = 3;code = 51
char = 0;code = 48
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 1;code = 49
char = 6;code = 54
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char = ,;code = 44
char = ;code = 32
char = l;code = 108
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char = h;code = 104
char = o;code = 111
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char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = d;code = 100
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char = c;code = 99
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char = 1;code = 49
char = 8;code = 56
char = 1;code = 49
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char = m;code = 109
char = o;code = 111
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char = /;code = 47
char = L;code = 76
char = );code = 41
char = ;code = 32
char = (;code = 40
char = 5;code = 53
char = 4;code = 52
char = 9;code = 57
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char = 9;code = 57
char = 2;code = 50
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char = &;code = 38
char = #;code = 35
char = 1;code = 49
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char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = 9;code = 57
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char = 7;code = 55
char = 8;code = 56
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char = v;code = 118
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char = 7;code = 55
char = 0;code = 48
char = 7;code = 55
char = .;code = 46
char = 2;code = 50
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char = &;code = 38
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char = 1;code = 49
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char = 7;code = 55
char = ;;code = 59
char = ;code = 32
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char = 4;code = 52
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char = e;code = 101
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char = (;code = 40
char = 1;code = 49
char = 1;code = 49
char = .;code = 46
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char = &;code = 38
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char = 7;code = 55
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char = m;code = 109
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char = N;code = 78
char = A;code = 65
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char = e;code = 101
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char = >;code = 62
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result sql = OBJECTIVE : To investigate the potential preventive effects of metformin on non-alcoholic fatty liver disease (NAFLD) and roles of phospholipase A2/lysophosphatidylcholine pathway in hepatocyte lipoapoptosis in a rat NAFLD model induced by high-fat diet.

METHOD : Male SD rats (n = 36) were randomly divided into three groups with 12 rats in each and treated with different diet and drugs: group I: ordinary diet, group II: high-fat diet, group III: high-fat diet and metformin. Ten weeks later, the rats were sacrificed and their body weight and liver weight were obtained, serum lipid metabolic indexes, insulin resistance indexes and secretory phospholipase A2 (sPLA2), lysophosphatidylcholine (LPC) levels and other parameters were measured. Phospholipase A2 mRNA expression levels were measured by quantitative reverse transcription-polymerase chain reaction (RT-PCR). In addition, the histological changes of liver tissue were analyzed.

RESULT : Compared to ordinary diet group, the rat's liver weight (g) (16.92 ± 2.49 vs. 12.16 ± 0.82), hepatic exponent (0.034 ± 0.004 vs. 0.026 ± 0.002), serum alanine aminotransferase (U/L) (45.43 ± 9.73 vs. 29.42 ± 6.73), triglyceride (mmol/L) (1.22 ± 0.24 vs. 0.85 ± 0.19), cholesterol (mmol/L) (2.00 ± 0.37 vs. 1.49 ± 0.33), lipoprotein(a) (mmol/L) (743.86 ± 32.19 vs. 648.42 ± 78.87), low-density lipoprotein (mmol/L) (1.31 ± 0.35 vs. 0.65 ± 0.22), insulin (mmol/L) (22.16 ± 5.16 vs. 16.86 ± 5.35), insulin resistance index(5.10 ± 1.45 vs. 3.59 ± 0.99), free fatty acid (mEq/L) (0.57 ± 0.10 vs. 0.35 ± 0.07), sPLA2 [µmol/(min·ml)] (0.130 ± 0.016 vs. 0.098 ± 0.024), lysophosphatidylcholine (µmol/L) (707.26 ± 92.48 vs. 508.87 ± 96.50), leptin (pg/ml (80.08 ± 17.73 vs. 65.11 ± 14.09), liver triglyceride (mg/g) (13.57 ± 0.65 vs. 12.03 ± 1.14), cholesterol (mg/g) (2.19 ± 0.15 vs. 1.94 ± 0.12) (P < 0.05) were significantly increased in high-fat diet group. Moreover, degree of hepatic steatosis was significantly higher and sPLA2 mRNA expression was also significantly increased. Secondly, in comparison with high-fat diet group, early metformin treatment significantly reduced the rat's body weight (g) (394.40 ± 33.10 vs. 491.86 ± 26.45), liver weight (g) (13.24 ± 1.16 vs. 16.92 ± 2.49), serum alanine aminotransferase (U/L) (30.40 ± 4.50 vs. 45.43 ± 9.73), triglyceride (mmol/L) (0.75 ± 0.19 vs. 1.22 ± 0.24), cholesterol (mmol/L) (1.61 ± 0.38 vs. 2.00 ± 0.37), insulin (mmol/L) (16.96 ± 5.60 vs. 22.16 ± 5.16), insulin resistance index (3.75 ± 1.41 vs. 5.10 ± 1.45), sPLA2 [µmol/(min·ml)] (0.101 ± 0.009 vs. 0.130 ± 0.016), lysophosphatidylcholine (µmol/L) (549.92 ± 90.78 vs. 707.26 ± 92.48), liver triglyceride (mg/g) (11.23 ± 1.70 vs. 13.57 ± 0.65), cholesterol (mg/g) (1.97 ± 0.20 vs. 2.19 ± 0.15) (P < 0.05). Moreover, degree of hepatic steatosis was significantly lower and sPLA2 mRNA expression was also significantly decreased by metformin. Thirdly, when compared to ordinary diet group, metformin could also significantly increase hepatic exponent (0.034 ± 0.004 vs. 0.026 ± 0.002) and low-density lipoprotein level (mmol/L) (0.96 ± 0.34 vs. 0.65 ± 0.22) (P < 0.05). However, it had no impact on hepatic steatosis and sPLA2 expression (P > 0.05).

CONCLUSION : It was indicated that metformin has potent effects on improving lipid metabolism and insulin resistance in high-fat diet induced non-alcoholic fatty liver disease rat model. The liver protective mechanisms of metformin in non-alcoholic fatty liver disease may be contributed to down-regulation of secretory phospholipase A2 mRNA expression, decrease in serum secretory phospholipase A2, lysophosphatidylcholine, lower inflammatory response and protect mitochondrial function.

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