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result sql = Hammada scoparia flavonoids and rutin kill adherent and chemoresistant leukemic cells.
Hammada scoparia flavonoids and rutin kill adherent and chemoresistant leukemic cells.
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result sql = In search for compounds able to reduce cell adhesion-mediated drug resistance (CAM-DR), we studied effects of Hammada scoparia extracts on leukemic cells adherent or in suspension. We show that H. scoparia flavonoidic fraction and its compound rutin induce apoptosis specifically in adherent leukemic cells and abolish CAM-DR. Importantly, rutin inhibited survival of adherent leukemic progenitors (CD34(+)38(-)123(+)) but spared normal progenitors (CD34(+)38(-)). The pro-apoptotic effects of rutin were correlated with a decrease of active GSK3β and inhibitors of GSK3β reproduced rutin-induced cytotoxicity. This study uncovers the potential of H. scoparia flavonoids and rutin to overcome CAM-DR in acute myeloid leukemia.

Publication: Leuk. Res. 2011 Aug ;35(8)::1093-101. :doi: 10.1016/j.leukres.2010.12.011.
Publication Date: 2011 Aug
Study Author(s): Bourogaa, Ezzeddine;Bertrand, Jessica;Despeaux, Mathieu;Jarraya, Raoudha;Fabre, Nicolas;Payrastre, Laurence;Demur, Cécile;Fournié, Jean-Jacques;Damak, Mohamed;Feki, Abdelfattah El;Racaud-Sultan, Claire;
Institution: Laboratoire de Chimie des Substances Naturelles, Sfax, Tunisia.
Shortcut link to this study:
In search for compounds able to reduce cell adhesion-mediated drug resistance (CAM-DR), we studied effects of Hammada scoparia extracts on leukemic cells adherent or in suspension. We show that H. scoparia flavonoidic fraction and its compound rutin induce apoptosis specifically in adherent leukemic cells and abolish CAM-DR. Importantly, rutin inhibited survival of adherent leukemic progenitors (CD34(+)38(-)123(+)) but spared normal progenitors (CD34(+)38(-)). The pro-apoptotic effects of rutin were correlated with a decrease of active GSK3β and inhibitors of GSK3β reproduced rutin-induced cytotoxicity. This study uncovers the potential of H. scoparia flavonoids and rutin to overcome CAM-DR in acute myeloid leukemia.
PMID: 21216465

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