|
|
char = R;code = 82
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char = r;code = 114
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char = r;code = 114
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char = A;code = 65
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char = P;code = 80
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char = .;code = 46
result sql = Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.
Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.char = R;code = 82
char = e;code = 101
char = s;code = 115
char = v;code = 118
char = e;code = 101
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char = a;code = 97
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char = o;code = 111
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char = ;code = 32
char = a;code = 97
char = ;code = 32
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = u;code = 117
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char = m;code = 109
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char = s;code = 115
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char = o;code = 111
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char = a;code = 97
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char = l;code = 108
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char = c;code = 99
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result sql = Resveratrol is a natural polyphenolic compound with cancer chemopreventive activity. However, our understanding of the molecular mechanism responsible for resveratrol-induced apoptosis is still very limited. Here, we used MCF-7 and MDA-MB231 breast cancer cells as a model to demonstrate that resveratrol induced the expression of ASPP1, a new member of the ASPP (apoptosis stimulation protein of p53) family, which plays an important role in the regulation of apoptosis. Moreover, resveratrol enhanced apoptosis of MCF-7/ASPP1 cells, accompanied by higher expression of bax and p21. In contrast, siRNA-mediated knockdown of ASPP1 inhibited apoptosis in MB231 cells. Furthermore, we found that higher levels of ASPP1 were associated with adenovirus-mediated overexpression of E2F1 while siRNA-mediated E2F1 knockdown led to down-regulation of ASPP1. In conclusion, our results demonstrate that overexpression of ASPP1 rendered MCF-7 and MDA-MB231 breast cancer cells more sensitive to resveratrol-mediated apoptosis via the E2F pathway, thus suggesting that ASPP1 may represent a novel therapeutic target for resveratrol in human breast cancer.
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result sql = Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.
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result sql = Resveratrol is a natural polyphenolic compound with cancer chemopreventive activity. However, our understanding of the molecular mechanism responsible for resveratrol-induced apoptosis is still very limited. Here, we used MCF-7 and MDA-MB231 breast cancer cells as a model to demonstrate that resveratrol induced the expression of ASPP1, a new member of the ASPP (apoptosis stimulation protein of p53) family, which plays an important role in the regulation of apoptosis. Moreover, resveratrol enhanced apoptosis of MCF-7/ASPP1 cells, accompanied by higher expression of bax and p21. In contrast, siRNA-mediated knockdown of ASPP1 inhibited apoptosis in MB231 cells. Furthermore, we found that higher levels of ASPP1 were associated with adenovirus-mediated overexpression of E2F1 while siRNA-mediated E2F1 knockdown led to down-regulation of ASPP1. In conclusion, our results demonstrate that overexpression of ASPP1 rendered MCF-7 and MDA-MB231 breast cancer cells more sensitive to resveratrol-mediated apoptosis via the E2F pathway, thus suggesting that ASPP1 may represent a novel therapeutic target for resveratrol in human breast cancer.
Publication: Oncol. Rep. 2011 Jun ;25(6)::1713-9. :doi: 10.3892/or.2011.1248.
Publication Date: 2011 Jun
Study Author(s): Shi, Yujie;Yang, Shihe;Troup, Sandi;Lu, Xin;Callaghan, Steve;Park, David S;Xing, Ying;Yang, Xiaohe;
Institution: Department of Physiology, College of Basic Medical Science, Zhengzhou University, Zhengzhou 450001, Henan, PR China.
Shortcut link to this study:
Publication Date: 2011 Jun
Study Author(s): Shi, Yujie;Yang, Shihe;Troup, Sandi;Lu, Xin;Callaghan, Steve;Park, David S;Xing, Ying;Yang, Xiaohe;
Institution: Department of Physiology, College of Basic Medical Science, Zhengzhou University, Zhengzhou 450001, Henan, PR China.
Shortcut link to this study:
Resveratrol is a natural polyphenolic compound with cancer chemopreventive activity. However, our understanding of the molecular mechanism responsible for resveratrol-induced apoptosis is still very limited. Here, we used MCF-7 and MDA-MB231 breast cancer cells as a model to demonstrate that resveratrol induced the expression of ASPP1, a new member of the ASPP (apoptosis stimulation protein of p53) family, which plays an important role in the regulation of apoptosis. Moreover, resveratrol enhanced apoptosis of MCF-7/ASPP1 cells, accompanied by higher expression of bax and p21. In contrast, siRNA-mediated knockdown of ASPP1 inhibited apoptosis in MB231 cells. Furthermore, we found that higher levels of ASPP1 were associated with adenovirus-mediated overexpression of E2F1 while siRNA-mediated E2F1 knockdown led to down-regulation of ASPP1. In conclusion, our results demonstrate that overexpression of ASPP1 rendered MCF-7 and MDA-MB231 breast cancer cells more sensitive to resveratrol-mediated apoptosis via the E2F pathway, thus suggesting that ASPP1 may represent a novel therapeutic target for resveratrol in human breast cancer.
PMID: 21479363
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