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result sql = Characterisation of spinosad resistance in the housefly Musca domestica (Diptera: Muscidae).
Characterisation of spinosad resistance in the housefly Musca domestica (Diptera: Muscidae).
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char = p;code = 112
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char = e;code = 101
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char = o;code = 111
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char = t;code = 116
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char = m;code = 109
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char = o;code = 111
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char = s;code = 115
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char = a;code = 97
char = n;code = 110
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char = e;code = 101
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char = s;code = 115
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char = r;code = 114
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char = y;code = 121
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char = l;code = 108
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
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char = o;code = 111
char = r;code = 114
char = e;code = 101
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char = h;code = 104
char = a;code = 97
char = n;code = 110
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char = n;code = 110
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = e;code = 101
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char = e;code = 101
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char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = v;code = 118
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char = d;code = 100
char = e;code = 101
char = ;code = 32
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char = e;code = 101
char = ;code = 32
char = b;code = 98
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char = i;code = 105
char = c;code = 99
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char = i;code = 105
char = n;code = 110
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
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char = o;code = 111
char = r;code = 114
char = ;code = 32
char = d;code = 100
char = e;code = 101
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char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = n;code = 110
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char = ;code = 32
char = s;code = 115
char = u;code = 117
char = c;code = 99
char = c;code = 99
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = f;code = 102
char = u;code = 117
char = l;code = 108
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char = m;code = 109
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char = e;code = 101
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char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = h;code = 104
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = e;code = 101
char = f;code = 102
char = l;code = 108
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = C;code = 67
char = o;code = 111
char = p;code = 112
char = y;code = 121
char = r;code = 114
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = t;code = 116
char = ;code = 32
char = &;code = 38
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char = 1;code = 49
char = 6;code = 54
char = 9;code = 57
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char = ;code = 32
char = 2;code = 50
char = 0;code = 48
char = 1;code = 49
char = 1;code = 49
char = ;code = 32
char = S;code = 83
char = o;code = 111
char = c;code = 99
char = i;code = 105
char = e;code = 101
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = C;code = 67
char = h;code = 104
char = e;code = 101
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = y;code = 121
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char = <;code = 60
char = b;code = 98
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char = /;code = 47
char = >;code = 62
result sql = BACKGROUND: Spinosad, a relatively new, effective and safe pesticide, has been widely used in pest control over the last 10 years. However, different levels of resistance to this insecticide have developed in some insects worldwide.

RESULTS: After continuous selection for 27 generations, a strain (SpRR) of the housefly developed 247-fold resistance to spinosad compared with the laboratory susceptible strain (CSS). The estimated realised heritability (h(2)) of spinosad resistance was 0.14. There was no significant difference in the LD(50) values and slopes between reciprocal progenies F(1) and F(1)', and values of 0.33 (F(1)) and 0.30 (F(1)') were obtained for the degree of dominance. Chi-square analysis from responses of self-bred (F(2)) and backcrosses (BC(1) and BC(2)) were highly significant, suggesting that the resistance was probably controlled by more than one gene. Synergists piperonyl butoxide (PBO), diethyl maleate (DEM) and S,S,S-tributyl phosphorotrithioate (DEF) affected the toxicity of spinosad at a low level, and demonstrated that metabolic-mediated detoxification was not an important factor in conferring resistance to spinosad in the SpRR strain.

CONCLUSION: It was concluded that spinosad resistance in the housefly was autosomal and incompletely dominant, and the resistance was probably controlled by more than one gene. These results provide the basic information for designing successful management programmes for the control of houseflies. Copyright © 2011 Society of Chemical Industry.

Publication: Pest Manag. Sci. 2011 Jan 11 ;:.
Publication Date: 2011 Jan 11
Study Author(s): Shi, Jing;Zhang, Lan;Gao, Xiwu;
Institution: Department of Entomology, China Agricultural University, Beijing, China.
Shortcut link to this study:
BACKGROUND: Spinosad, a relatively new, effective and safe pesticide, has been widely used in pest control over the last 10 years. However, different levels of resistance to this insecticide have developed in some insects worldwide.

RESULTS: After continuous selection for 27 generations, a strain (SpRR) of the housefly developed 247-fold resistance to spinosad compared with the laboratory susceptible strain (CSS). The estimated realised heritability (h(2)) of spinosad resistance was 0.14. There was no significant difference in the LD(50) values and slopes between reciprocal progenies F(1) and F(1)', and values of 0.33 (F(1)) and 0.30 (F(1)') were obtained for the degree of dominance. Chi-square analysis from responses of self-bred (F(2)) and backcrosses (BC(1) and BC(2)) were highly significant, suggesting that the resistance was probably controlled by more than one gene. Synergists piperonyl butoxide (PBO), diethyl maleate (DEM) and S,S,S-tributyl phosphorotrithioate (DEF) affected the toxicity of spinosad at a low level, and demonstrated that metabolic-mediated detoxification was not an important factor in conferring resistance to spinosad in the SpRR strain.

CONCLUSION: It was concluded that spinosad resistance in the housefly was autosomal and incompletely dominant, and the resistance was probably controlled by more than one gene. These results provide the basic information for designing successful management programmes for the control of houseflies. Copyright © 2011 Society of Chemical Industry.
PMID: 21226004

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