char = O;code = 79
char = R;code = 82
char = A;code = 65
char = I;code = 73
char = 1;code = 49
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char = a;code = 97
char = l;code = 108
char = c;code = 99
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char = u;code = 117
char = m;code = 109
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char = i;code = 105
char = n;code = 110
char = f;code = 102
char = l;code = 108
char = u;code = 117
char = x;code = 120
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char = a;code = 97
char = c;code = 99
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = b;code = 98
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = .;code = 46
result sql = ORAI1-mediated calcium influx in lactation and in breast cancer.
ORAI1-mediated calcium influx in lactation and in breast cancer.
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = n;code = 110
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char = r;code = 114
char = y;code = 121
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char = o;code = 111
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char = ;code = 32
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = i;code = 105
char = u;code = 117
char = m;code = 109
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char = i;code = 105
char = n;code = 110
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = m;code = 109
char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
char = r;code = 114
char = y;code = 121
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char = p;code = 112
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char = e;code = 101
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char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = f;code = 102
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char = o;code = 111
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char = e;code = 101
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char = a;code = 97
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char = p;code = 112
char = l;code = 108
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char = m;code = 109
char = a;code = 97
char = ;code = 32
char = (;code = 40
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char = e;code = 101
char = .;code = 46
char = ,;code = 44
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char = c;code = 99
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char = i;code = 105
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char = i;code = 105
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char = m;code = 109
char = s;code = 115
char = );code = 41
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char = d;code = 100
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char = a;code = 97
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char = i;code = 105
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = o;code = 111
char = r;code = 114
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = t;code = 116
char = o;code = 111
char = o;code = 111
char = d;code = 100
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = i;code = 105
char = u;code = 117
char = m;code = 109
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char = c;code = 99
char = h;code = 104
char = a;code = 97
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char = n;code = 110
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char = d;code = 100
char = ;code = 32
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char = u;code = 117
char = m;code = 109
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char = s;code = 115
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char = ;code = 32
char = a;code = 97
char = ;code = 32
char = k;code = 107
char = e;code = 101
char = y;code = 121
char = ;code = 32
char = f;code = 102
char = e;code = 101
char = a;code = 97
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char = u;code = 117
char = r;code = 114
char = e;code = 101
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char = o;code = 111
char = f;code = 102
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char = s;code = 115
char = o;code = 111
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char = s;code = 115
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char = d;code = 100
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char = g;code = 103
char = ;code = 32
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char = e;code = 101
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char = e;code = 101
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char = c;code = 99
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = i;code = 105
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = f;code = 102
char = l;code = 108
char = u;code = 117
char = x;code = 120
char = ;code = 32
char = p;code = 112
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char = t;code = 116
char = h;code = 104
char = w;code = 119
char = a;code = 97
char = y;code = 121
char = s;code = 115
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char = m;code = 109
char = a;code = 97
char = y;code = 121
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char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
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char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = y;code = 121
char = o;code = 111
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = b;code = 98
char = i;code = 105
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = y;code = 121
char = .;code = 46
char = ;code = 32
char = W;code = 87
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = h;code = 104
char = o;code = 111
char = w;code = 119
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = s;code = 115
char = t;code = 116
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char = r;code = 114
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char = -;code = 45
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = c;code = 99
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char = u;code = 117
char = m;code = 109
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = f;code = 102
char = l;code = 108
char = u;code = 117
char = x;code = 120
char = ;code = 32
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char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = O;code = 79
char = r;code = 114
char = a;code = 97
char = i;code = 105
char = 1;code = 49
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = d;code = 100
char = u;code = 117
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = c;code = 99
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = w;code = 119
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = O;code = 79
char = r;code = 114
char = a;code = 97
char = i;code = 105
char = 1;code = 49
char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = i;code = 105
char = v;code = 118
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
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char = S;code = 83
char = t;code = 116
char = i;code = 105
char = m;code = 109
char = 1;code = 49
char = ,;code = 44
char = ;code = 32
char = b;code = 98
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char = t;code = 116
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char = n;code = 110
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char = t;code = 116
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char = S;code = 83
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char = i;code = 105
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char = d;code = 100
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char = m;code = 109
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char = ;code = 32
char = s;code = 115
char = i;code = 105
char = R;code = 82
char = N;code = 78
char = A;code = 65
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char = r;code = 114
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char = d;code = 100
char = u;code = 117
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char = e;code = 101
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char = a;code = 97
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char = ;code = 32
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char = a;code = 97
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char = c;code = 99
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char = r;code = 114
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char = t;code = 116
char = s;code = 115
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char = g;code = 103
char = g;code = 103
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = c;code = 99
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char = c;code = 99
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char = h;code = 104
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = g;code = 103
char = h;code = 104
char = ;code = 32
char = O;code = 79
char = r;code = 114
char = a;code = 97
char = i;code = 105
char = 1;code = 49
char = ,;code = 44
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char = a;code = 97
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char = v;code = 118
char = a;code = 97
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char = S;code = 83
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char = i;code = 105
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char = I;code = 73
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char = I;code = 73
char = 1;code = 49
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char = s;code = 115
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char = R;code = 82
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result sql = The entry of calcium into the mammary epithelial cell from the maternal plasma (i.e., calcium influx mechanisms) during lactation is poorly understood. As alterations in calcium channels and pumps are a key feature of some cancers, including breast cancer, understanding these calcium influx pathways may have significance beyond mammary biology. We show that the store-operated calcium influx protein, Orai1, is increased during lactation whereas the Orai1 activator Stim1, but not Stim2, is downregulated. Stim2 siRNA reduced basal calcium levels in a lactation model. Our results suggest that calcium influx is remodeled in mammary epithelial cells during lactation, with calcium influx increased through Orai1, activated by Stim2. Breast cancer cell lines had increased levels of ORAI1. ORAI1 siRNA in breast cancer cells reduced store-operated calcium entry and remodeled the calcium influx associated with invasive stimuli. Analysis of microarray data from 295 breast cancers showed that the transcriptional breast cancer subtype with the poorest prognosis (basal) was associated with an altered relationship between the ORAI1 regulators STIM1 and STIM2, and that women with breast cancers with STIM1(high)/STIM2(low) tumors had a significantly poorer prognosis. Our studies show that during lactation there is a remodeling in the nature of calcium influx and that alteration in the ORAI1 influx pathway may be a feature of some breast cancers, particularly those with the poorest prognosis. Our studies suggest that this pathway may be a novel therapeutic target for breast cancer treatment in these women.

Publication: Mol. Cancer Ther. 2011 Mar ;10(3)::448-60. :doi: 10.1158/1535-7163.MCT-10-0923.
Publication Date: 2011 Mar
Study Author(s): McAndrew, Damara;Grice, Desma M;Peters, Amelia A;Davis, Felicity M;Stewart, Teneale;Rice, Michelle;Smart, Chanel E;Brown, Melissa A;Kenny, Paraic A;Roberts-Thomson, Sarah J;Monteith, Gregory R;
Institution: School of Pharmacy, The University of Queensland, Brisbane, Queensland Australia, 4072.
Shortcut link to this study:
The entry of calcium into the mammary epithelial cell from the maternal plasma (i.e., calcium influx mechanisms) during lactation is poorly understood. As alterations in calcium channels and pumps are a key feature of some cancers, including breast cancer, understanding these calcium influx pathways may have significance beyond mammary biology. We show that the store-operated calcium influx protein, Orai1, is increased during lactation whereas the Orai1 activator Stim1, but not Stim2, is downregulated. Stim2 siRNA reduced basal calcium levels in a lactation model. Our results suggest that calcium influx is remodeled in mammary epithelial cells during lactation, with calcium influx increased through Orai1, activated by Stim2. Breast cancer cell lines had increased levels of ORAI1. ORAI1 siRNA in breast cancer cells reduced store-operated calcium entry and remodeled the calcium influx associated with invasive stimuli. Analysis of microarray data from 295 breast cancers showed that the transcriptional breast cancer subtype with the poorest prognosis (basal) was associated with an altered relationship between the ORAI1 regulators STIM1 and STIM2, and that women with breast cancers with STIM1(high)/STIM2(low) tumors had a significantly poorer prognosis. Our studies show that during lactation there is a remodeling in the nature of calcium influx and that alteration in the ORAI1 influx pathway may be a feature of some breast cancers, particularly those with the poorest prognosis. Our studies suggest that this pathway may be a novel therapeutic target for breast cancer treatment in these women.
PMID: 21224390

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