Scientific studies on Ebola

Last updated: September 25, 2013
Protection against lethal challenge by Ebola virus-like particles produced in insect cells.

Successful topical respiratory tract immunization of primates against Ebola virus.
Journal of virology

Tackling Ebola: new insights into prophylactic and therapeutic intervention strategies.
Genome medicine

Phosphoinositide-3 kinase-Akt pathway controls cellular entry of Ebola virus.
PLoS pathogens

Enhanced protection against Ebola virus mediated by an improved adenovirus-based vaccine.
PloS one

Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.
PLoS pathogens

Requirements for cell rounding and surface protein down-regulation by Ebola virus glycoprotein.

Ebola haemorrhagic fever.

Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America

Effective post-exposure treatment of Ebola infection.
PLoS pathogens

ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity.
Proceedings of the National Academy of Sciences of the United States of America

Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein.
Journal of virology

The VP35 protein of Ebola virus impairs dendritic cell maturation induced by virus and lipopolysaccharide.
The Journal of general virology

Protection of nonhuman primates against two species of Ebola virus infection with a single complex adenovirus vector.
Clinical and vaccine immunology : CVI

Human Ebola outbreak resulting from direct exposure to fruit bats in Luebo, Democratic Republic of Congo, 2007.
Vector borne and zoonotic diseases (Larchmont, N.Y.)

Cross-platform evaluation of commercial real-time reverse transcription PCR master mix kits using a quantitative 5'nuclease assay for Ebola virus.
Molecular and cellular probes

A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.
Molecular pharmacology

Single-injection vaccine protects nonhuman primates against infection with marburg virus and three species of ebola virus.
Journal of virology

Structural and functional characterization of Reston Ebola virus VP35 interferon inhibitory domain.
Journal of molecular biology

Inhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virus.
Journal of virology

Lessons learned during active epidemiological surveillance of ebola and marburg viral hemorrhagic fever epidemics in Africa.
East African journal of public health

A replication defective recombinant Ad5 vaccine expressing Ebola virus GP is safe and immunogenic in healthy adults.

Ebola virus infection of human PBMCs causes massive death of macrophages, CD4 and CD8 T cell sub-populations in vitro.

Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys.
PLoS pathogens

Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana.
Plant biotechnology journal

Full-length Ebola glycoprotein accumulates in the endoplasmic reticulum.
Virology journal

Measuring the strength of interaction between the Ebola fusion peptide and lipid rafts: implications for membrane fusion and virus infection.
PloS one

High-dose mannose-binding lectin therapy for Ebola virus infection.
The Journal of infectious diseases

Replication-deficient ebolavirus as a vaccine candidate.
Journal of virology

Potential for Ebola transmission between gorilla and chimpanzee social groups.
The American naturalist

Proteolytic processing of the Ebola virus glycoprotein is not critical for Ebola virus replication in nonhuman primates.
Journal of virology

Mapping of the VP40-binding regions of the nucleoprotein of Ebola virus.
Journal of virology

Development of a broad-spectrum antiviral with activity against Ebola virus.
Antiviral research

Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates.
Journal of virology

Large serological survey showing cocirculation of Ebola and Marburg viruses in Gabonese bat populations, and a high seroprevalence of both viruses in Rousettus aegyptiacus.
BMC infectious diseases

A filovirus-unique region of Ebola virus nucleoprotein confers aberrant migration and mediates its incorporation into virions.
Journal of virology

Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery.
PLoS pathogens

Ebola hemorrhagic fever associated with novel virus strain, Uganda, 2007-2008.
Emerging infectious diseases

The 1995 Kikwit Ebola outbreak--model of virus properties on system capacity and function: a lesson for future viral epidemics.
American journal of disaster medicine