char = H;code = 72 char = u;code = 117 char = m;code = 109 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = p;code = 112 char = i;code = 105 char = l;code = 108 char = l;code = 108 char = o;code = 111 char = m;code = 109 char = a;code = 97 char = v;code = 118 char = i;code = 105 char = r;code = 114 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = c;code = 99 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = i;code = 105 char = a;code = 97 char = l;code = 108 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = i;code = 105 char = b;code = 98 char = u;code = 117 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = :;code = 58 char = ;code = 32 char = V;code = 86 char = a;code = 97 char = c;code = 99 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = e;code = 101 char = f;code = 102 char = f;code = 102 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = c;code = 99 char = y;code = 121 char = .;code = 46 result sql = Human papillomavirus vaccine trials and tribulations: Vaccine efficacy.
Human papillomavirus vaccine trials and tribulations: Vaccine efficacy.char = A;code = 65 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = D;code = 68 char = e;code = 101 char = c;code = 99 char = e;code = 101 char = m;code = 109 char = b;code = 98 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = 2;code = 50 char = 0;code = 48 char = 1;code = 49 char = 4;code = 52 char = ,;code = 44 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = 3;code = 51 char = ;code = 32 char = a;code = 97 char = p;code = 112 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = v;code = 118 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = c;code = 99 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = h;code = 104 char = u;code = 117 char = m;code = 109 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = p;code = 112 char = i;code = 105 char = l;code = 108 char = l;code = 108 char = o;code = 111 char = m;code = 109 char = a;code = 97 char = v;code = 118 char = i;code = 105 char = r;code = 114 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = H;code = 72 char = P;code = 80 char = V;code = 86 char = );code = 41 char = :;code = 58 char = ;code = 32 char = b;code = 98 char = i;code = 105 char = v;code = 118 char = a;code = 97 char = l;code = 108 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = C;code = 67 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = a;code = 97 char = r;code = 114 char = i;code = 105 char = x;code = 120 char = ;code = 32 char = (;code = 40 char = G;code = 71 char = l;code = 108 char = a;code = 97 char = x;code = 120 char = o;code = 111 char = S;code = 83 char = m;code = 109 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = K;code = 75 char = l;code = 108 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ,;code = 44 char = ;code = 32 char = N;code = 78 char = e;code = 101 char = w;code = 119 char = ;code = 32 char = Y;code = 89 char = o;code = 111 char = r;code = 114 char = k;code = 107 char = ,;code = 44 char = ;code = 32 char = N;code = 78 char = Y;code = 89 char = );code = 41 char = ,;code = 44 char = ;code = 32 char = q;code = 113 char = u;code = 117 char = a;code = 97 char = d;code = 100 char = r;code = 114 char = i;code = 105 char = v;code = 118 char = a;code = 97 char = l;code = 108 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = G;code = 71 char = a;code = 97 char = r;code = 114 char = d;code = 100 char = a;code = 97 char = s;code = 115 char = i;code = 105 char = l;code = 108 char = ;code = 32 char = (;code = 40 char = M;code = 77 char = e;code = 101 char = r;code = 114 char = c;code = 99 char = k;code = 107 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = C;code = 67 char = o;code = 111 char = ,;code = 44 char = ;code = 32 char = K;code = 75 char = e;code = 101 char = n;code = 110 char = i;code = 105 char = l;code = 108 char = w;code = 119 char = o;code = 111 char = r;code = 114 char = t;code = 116 char = h;code = 104 char = ,;code = 44 char = ;code = 32 char = N;code = 78 char = J;code = 74 char = );code = 41 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = 9;code = 57 char = -;code = 45 char = v;code = 118 char = a;code = 97 char = l;code = 108 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = G;code = 71 char = a;code = 97 char = r;code = 114 char = d;code = 100 char = a;code = 97 char = s;code = 115 char = i;code = 105 char = l;code = 108 char = -;code = 45 char = 9;code = 57 char = ;code = 32 char = (;code = 40 char = M;code = 77 char = e;code = 101 char = r;code = 114 char = c;code = 99 char = k;code = 107 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = C;code = 67 char = o;code = 111 char = );code = 41 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = g;code = 103 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = d;code = 100 char = o;code = 111 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = $;code = 36 char = 1;code = 49 char = 2;code = 50 char = 0;code = 48 char = ,;code = 44 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = d;code = 100 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = 3;code = 51 char = -;code = 45 char = d;code = 100 char = o;code = 111 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = u;code = 117 char = r;code = 114 char = s;code = 115 char = e;code = 101 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = q;code = 113 char = u;code = 117 char = a;code = 97 char = d;code = 100 char = r;code = 114 char = i;code = 105 char = v;code = 118 char = a;code = 97 char = l;code = 108 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = c;code = 99 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = d;code = 100 char = e;code = 101 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = d;code = 100 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = o;code = 111 char = r;code = 114 char = l;code = 108 char = d;code = 100 char = w;code = 119 char = i;code = 105 char = d;code = 100 char = e;code = 101 char = .;code = 46 char = ;code = 32 char = A;code = 65 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = b;code = 98 char = i;code = 105 char = v;code = 118 char = a;code = 97 char = l;code = 108 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = 9;code = 57 char = -;code = 45 char = v;code = 118 char = a;code = 97 char = l;code = 108 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = c;code = 99 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = c;code = 99 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = i;code = 105 char = d;code = 100 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = s;code = 115 char = a;code = 97 char = f;code = 102 char = e;code = 101 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = t;code = 116 char = h;code = 104 char = o;code = 111 char = u;code = 117 char = g;code = 103 char = h;code = 104 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = r;code = 114 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = h;code = 104 char = a;code = 97 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = i;code = 105 char = s;code = 115 char = e;code = 101 char = d;code = 100 char = .;code = 46 char = ;code = 32 char = I;code = 73 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = d;code = 100 char = d;code = 100 char = i;code = 105 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = i;code = 105 char = m;code = 109 char = m;code = 109 char = u;code = 117 char = n;code = 110 char = i;code = 105 char = z;code = 122 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = g;code = 103 char = a;code = 97 char = i;code = 105 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = a;code = 97 char = r;code = 114 char = g;code = 103 char = e;code = 101 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = H;code = 72 char = P;code = 80 char = V;code = 86 char = ;code = 32 char = t;code = 116 char = y;code = 121 char = p;code = 112 char = e;code = 101 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = e;code = 101 char = v;code = 118 char = i;code = 105 char = d;code = 100 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = r;code = 114 char = o;code = 111 char = s;code = 115 char = s;code = 115 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = t;code = 116 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = g;code = 103 char = a;code = 97 char = i;code = 105 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = o;code = 111 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = t;code = 116 char = y;code = 121 char = p;code = 112 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = H;code = 72 char = P;code = 80 char = V;code = 86 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = n;code = 110 char = u;code = 117 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = m;code = 109 char = e;code = 101 char = d;code = 100 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = e;code = 101 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = v;code = 118 char = i;code = 105 char = e;code = 101 char = w;code = 119 char = ;code = 32 char = e;code = 101 char = v;code = 118 char = a;code = 97 char = l;code = 108 char = u;code = 117 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = d;code = 100 char = i;code = 105 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = c;code = 99 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = u;code = 117 char = r;code = 114 char = r;code = 114 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = m;code = 109 char = a;code = 97 char = r;code = 114 char = k;code = 107 char = e;code = 101 char = t;code = 116 char = ;;code = 59 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = t;code = 116 char = ;code = 32 char = I;code = 73 char = I;code = 73 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = c;code = 99 char = u;code = 117 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = -;code = 45 char = e;code = 101 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = n;code = 110 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = c;code = 99 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ,;code = 44 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = H;code = 72 char = P;code = 80 char = V;code = 86 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = c;code = 99 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = g;code = 103 char = r;code = 114 char = a;code = 97 char = m;code = 109 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = u;code = 117 char = r;code = 114 char = r;code = 114 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = t;code = 116 char = u;code = 117 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = g;code = 103 char = l;code = 108 char = o;code = 111 char = b;code = 98 char = e;code = 101 char = ,;code = 44 char = ;code = 32 char = e;code = 101 char = f;code = 102 char = f;code = 102 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = c;code = 99 char = y;code = 121 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = s;code = 115 char = a;code = 97 char = f;code = 102 char = e;code = 101 char = t;code = 116 char = y;code = 121 char = .;code = 46 result sql = As of December 2014, there were 3 approved vaccines for human papillomavirus (HPV): bivalent Cervarix (GlaxoSmithKline, New York, NY), quadrivalent Gardasil (Merck and Co, Kenilworth, NJ), and 9-valent Gardasil-9 (Merck and Co). The average cost per dose is $120, with a recommended 3-dose course. The quadrivalent vaccine is the most widely administered worldwide. As with the bivalent and 9-valent vaccines, the vaccine is considered safe, although concerns have been raised. In addition to immunization against the targeted HPV types, there is evidence that there is cross protection against other types of HPV. This continuing medical education review evaluates the differences in vaccines that are currently on the market; part II focuses on the cost-effectiveness of vaccination, the HPV vaccination programs currently instituted around the globe, efficacy, and safety.
Publication: J. Am. Acad. Dermatol. 2015 Nov;73(5):759-67; quiz 767-8.
Publication Date: Nov 2015
Study Author(s): Handler Nancy S NS ; Handler Marc Z MZ ; Majewski Slawomir S ; Schwartz Robert A RA ;
Institution: Dermatology, Rutgers University New Jersey Medical School, Newark, New Jersey; University of Nebraska Medical Center, College of Medicine, Omaha, Nebraska.
Shortcut link to this study:
As of December 2014, there were 3 approved vaccines for human papillomavirus (HPV): bivalent Cervarix (GlaxoSmithKline, New York, NY), quadrivalent Gardasil (Merck and Co, Kenilworth, NJ), and 9-valent Gardasil-9 (Merck and Co). The average cost per dose is $120, with a recommended 3-dose course. The quadrivalent vaccine is the most widely administered worldwide. As with the bivalent and 9-valent vaccines, the vaccine is considered safe, although concerns have been raised. In addition to immunization against the targeted HPV types, there is evidence that there is cross protection against other types of HPV. This continuing medical education review evaluates the differences in vaccines that are currently on the market; part II focuses on the cost-effectiveness of vaccination, the HPV vaccination programs currently instituted around the globe, efficacy, and safety.
PMID: 26475535