|
|
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char = h;code = 104
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char = o;code = 111
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char = i;code = 105
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char = .;code = 46
result sql = Glutathione and glutathione-related enzymes in colorectal cancer patients.
Glutathione and glutathione-related enzymes in colorectal cancer patients.char = I;code = 73
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char = r;code = 114
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char = ;code = 32
char = m;code = 109
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char = h;code = 104
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char = e;code = 101
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char = o;code = 111
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char = a;code = 97
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char = b;code = 98
char = e;code = 101
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char = n;code = 110
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char = o;code = 111
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char = l;code = 108
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char = e;code = 101
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char = (;code = 40
char = G;code = 71
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char = ;code = 32
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char = );code = 41
char = ,;code = 44
char = ;code = 32
char = g;code = 103
char = l;code = 108
char = u;code = 117
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = t;code = 116
char = a;code = 97
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char = e;code = 101
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char = (;code = 40
char = G;code = 71
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char = ;code = 32
char = R;code = 82
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char = S;code = 83
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char = r;code = 114
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = G;code = 71
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char = );code = 41
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char = b;code = 98
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char = .;code = 46
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char = I;code = 73
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char = G;code = 71
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char = H;code = 72
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char = l;code = 108
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char = ;code = 32
char = G;code = 71
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char = H;code = 72
char = ;code = 32
char = P;code = 80
char = x;code = 120
char = ,;code = 44
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char = G;code = 71
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char = H;code = 72
char = ;code = 32
char = R;code = 82
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char = ,;code = 44
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char = G;code = 71
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char = c;code = 99
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char = l;code = 108
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char = a;code = 97
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char = t;code = 116
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char = m;code = 109
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char = ;code = 32
char = (;code = 40
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char = =;code = 61
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char = 2;code = 50
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char = m;code = 109
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char = a;code = 97
char = g;code = 103
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char = 5;code = 53
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char = +;code = 43
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char = 8;code = 56
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char = 3;code = 51
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char = .;code = 46
char = ;code = 32
char = E;code = 69
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char = o;code = 111
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result sql = In recent years much attention has been focused on the role of glutathione (GSH) and GSH-related enzymes such as glutathione peroxidase (GSH Px), glutathione reductase (GSH Red), and glutathione S-transferase (GST) in the inhibition of free radical-induced carcinogenesis. In this study, erythrocyte GSH levels and activities of GSH Px, GSH Red, and GST were determined in patients with colorectal tumors (n = 20, mean age 54.5 +/- 8.3 yr). Erythrocyte GSH Red and GST activities were significantly higher in patients with colorectal tumors. Erythrocyte GSH levels and GSH Px activities were found to be significantly decreased in the patients. When the patients were classified based on their clinical grading (Dukes classifications), there was no significant difference in studied parameters between Dukes B and Dukes C. Our results suggest that oxidative stress may play an important role in colorectal tumorigenesis and that these events have no effect on the clinical grading of the colorectal tumor.
char = l;code = 108
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char = h;code = 104
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char = e;code = 101
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char = n;code = 110
char = d;code = 100
char = ;code = 32
char = g;code = 103
char = l;code = 108
char = u;code = 117
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char = t;code = 116
char = h;code = 104
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = e;code = 101
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char = e;code = 101
char = l;code = 108
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char = c;code = 99
char = o;code = 111
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char = o;code = 111
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char = .;code = 46
result sql = Glutathione and glutathione-related enzymes in colorectal cancer patients.
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result sql = In recent years much attention has been focused on the role of glutathione (GSH) and GSH-related enzymes such as glutathione peroxidase (GSH Px), glutathione reductase (GSH Red), and glutathione S-transferase (GST) in the inhibition of free radical-induced carcinogenesis. In this study, erythrocyte GSH levels and activities of GSH Px, GSH Red, and GST were determined in patients with colorectal tumors (n = 20, mean age 54.5 +/- 8.3 yr). Erythrocyte GSH Red and GST activities were significantly higher in patients with colorectal tumors. Erythrocyte GSH levels and GSH Px activities were found to be significantly decreased in the patients. When the patients were classified based on their clinical grading (Dukes classifications), there was no significant difference in studied parameters between Dukes B and Dukes C. Our results suggest that oxidative stress may play an important role in colorectal tumorigenesis and that these events have no effect on the clinical grading of the colorectal tumor.
Publication: J. Toxicol. Environ. Health Part A 2003 Mar 14 ;66(5)::411-5.
Publication Date: 2003 Mar 14
Study Author(s): Saygili, Eyüp Ilker;Akcay, Tülay;Konukoglu, Dildar;Papilla, Ciğdem;
Institution: Department of Biochemistry, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey. [email protected]
Shortcut link to this study:
Publication Date: 2003 Mar 14
Study Author(s): Saygili, Eyüp Ilker;Akcay, Tülay;Konukoglu, Dildar;Papilla, Ciğdem;
Institution: Department of Biochemistry, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey. [email protected]
Shortcut link to this study:
In recent years much attention has been focused on the role of glutathione (GSH) and GSH-related enzymes such as glutathione peroxidase (GSH Px), glutathione reductase (GSH Red), and glutathione S-transferase (GST) in the inhibition of free radical-induced carcinogenesis. In this study, erythrocyte GSH levels and activities of GSH Px, GSH Red, and GST were determined in patients with colorectal tumors (n = 20, mean age 54.5 +/- 8.3 yr). Erythrocyte GSH Red and GST activities were significantly higher in patients with colorectal tumors. Erythrocyte GSH levels and GSH Px activities were found to be significantly decreased in the patients. When the patients were classified based on their clinical grading (Dukes classifications), there was no significant difference in studied parameters between Dukes B and Dukes C. Our results suggest that oxidative stress may play an important role in colorectal tumorigenesis and that these events have no effect on the clinical grading of the colorectal tumor.
PMID: 12712629
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