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char = l;code = 108
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char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = s;code = 115
char = u;code = 117
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char = 1;code = 49
char = A;code = 65
char = 1;code = 49
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char = d;code = 100
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char = g;code = 103
char = l;code = 108
char = u;code = 117
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char = a;code = 97
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = S;code = 83
char = -;code = 45
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = P;code = 80
char = 1;code = 49
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = k;code = 107
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ';code = 39
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = r;code = 114
char = v;code = 118
char = i;code = 105
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = .;code = 46
result sql = Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients' survival.
Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients' survival.
char = <;code = 60
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char = <;code = 60
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char = e;code = 101
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char = h;code = 104
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char = m;code = 109
char = s;code = 115
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char = U;code = 85
char = L;code = 76
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char = 1;code = 49
char = A;code = 65
char = 1;code = 49
char = ;code = 32
char = a;code = 97
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char = G;code = 71
char = S;code = 83
char = T;code = 84
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char = e;code = 101
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char = o;code = 111
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char = o;code = 111
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char = e;code = 101
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char = a;code = 97
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char = ;code = 32
char = c;code = 99
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char = n;code = 110
char = c;code = 99
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char = r;code = 114
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = v;code = 118
char = e;code = 101
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char = o;code = 111
char = p;code = 112
char = m;code = 109
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char = ;code = 32
char = a;code = 97
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char = e;code = 101
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = y;code = 121
char = ;code = 32
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char = e;code = 101
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char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
char = c;code = 99
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = c;code = 99
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = o;code = 111
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
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char = b;code = 98
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char = a;code = 97
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char = o;code = 111
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char = i;code = 105
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char = e;code = 101
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char = i;code = 105
char = f;code = 102
char = i;code = 105
char = e;code = 101
char = d;code = 100
char = .;code = 46
char = <;code = 60
char = b;code = 98
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char = >;code = 62
char = <;code = 60
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char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
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char = M;code = 77
char = E;code = 69
char = T;code = 84
char = H;code = 72
char = O;code = 79
char = D;code = 68
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
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char = >;code = 62
char = W;code = 87
char = e;code = 101
char = ;code = 32
char = e;code = 101
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char = o;code = 111
char = l;code = 108
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char = i;code = 105
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char = ;code = 32
char = a;code = 97
char = ;code = 32
char = S;code = 83
char = w;code = 119
char = e;code = 101
char = d;code = 100
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char = s;code = 115
char = h;code = 104
char = ;code = 32
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char = p;code = 112
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char = y;code = 121
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char = i;code = 105
char = n;code = 110
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char = ;code = 32
char = P;code = 80
char = C;code = 67
char = R;code = 82
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char = t;code = 116
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char = a;code = 97
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char = ;code = 32
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char = h;code = 104
char = ;code = 32
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char = p;code = 112
char = h;code = 104
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char = s;code = 115
char = m;code = 109
char = ;code = 32
char = (;code = 40
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char = F;code = 70
char = L;code = 76
char = P;code = 80
char = );code = 41
char = .;code = 46
char = <;code = 60
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char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
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char = >;code = 62
char = R;code = 82
char = E;code = 69
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char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
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char = <;code = 60
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char = >;code = 62
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char = L;code = 76
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char = 1;code = 49
char = A;code = 65
char = 1;code = 49
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char = *;code = 42
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char = g;code = 103
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char = e;code = 101
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char = (;code = 40
char = O;code = 79
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char = 4;code = 52
char = 9;code = 57
char = ,;code = 44
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char = 5;code = 53
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char = C;code = 67
char = I;code = 73
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char = 1;code = 49
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char = 2;code = 50
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char = l;code = 108
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char = C;code = 67
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char = G;code = 71
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char = ;code = 32
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char = i;code = 105
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char = ;code = 32
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char = r;code = 114
char = o;code = 111
char = g;code = 103
char = n;code = 110
char = o;code = 111
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = a;code = 97
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result sql = AIM : To examine whether polymorphisms in SULT1A1 and GSTP1 genes contribute to colorectal cancer development and whether they are associated with clinicopathological variables are not well identified.

METHODS : We examined the genotypes of 125 colorectal cancer patients and 666 healthy controls in a Swedish population by using PCR-restriction fragment length polymorphism (RFLP).

RESULTS : SULT1A1 *2/*2 genotype (OR=2.49, 95%CI=1.48-4.19, P=0.0002) and *2 allele (OR=1.56, 95%CI=1.16-2.10, P=0.002) had an effect on colorectal cancer susceptibility, while GSTP1 genotype was without effect. However, GSTP1 G-type predicted a worse prognosis in the patients independently of gender, age, Dukes' stage, growth pattern, and differentiation (P=0.03).

CONCLUSION : Polymorphism in SULT1A1 may predispose to colorectal cancer and GSTP1 may be a biological indicator of prognosis in the patients.

Publication: World J. Gastroenterol. 2005 Nov 21 ;11(43)::6875-9.
Publication Date: 2005 Nov 21
Study Author(s): Sun, Xiao-Feng;Ahmadi, Ahmad;Arbman, Gunnar;Wallin, Asa;Asklid, Daniel;Zhang, Hong;
Institution: Department of Oncology, Institute of Biomedicine and Surgery, University of Linkoping, S-581 85 Linkoping, Sweden. [email protected]
Shortcut link to this study:
AIM : To examine whether polymorphisms in SULT1A1 and GSTP1 genes contribute to colorectal cancer development and whether they are associated with clinicopathological variables are not well identified.

METHODS : We examined the genotypes of 125 colorectal cancer patients and 666 healthy controls in a Swedish population by using PCR-restriction fragment length polymorphism (RFLP).

RESULTS : SULT1A1 *2/*2 genotype (OR=2.49, 95%CI=1.48-4.19, P=0.0002) and *2 allele (OR=1.56, 95%CI=1.16-2.10, P=0.002) had an effect on colorectal cancer susceptibility, while GSTP1 genotype was without effect. However, GSTP1 G-type predicted a worse prognosis in the patients independently of gender, age, Dukes' stage, growth pattern, and differentiation (P=0.03).

CONCLUSION : Polymorphism in SULT1A1 may predispose to colorectal cancer and GSTP1 may be a biological indicator of prognosis in the patients.
PMID: 16425401

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