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result sql = EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism.
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char = o;code = 111
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char = E;code = 69
char = F;code = 70
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char = t;code = 116
char = h;code = 104
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char = i;code = 105
char = v;code = 118
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char = i;code = 105
char = g;code = 103
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char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = e;code = 101
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char = l;code = 108
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
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char = G;code = 71
char = S;code = 83
char = H;code = 72
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = o;code = 111
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char = d;code = 100
char = i;code = 105
char = z;code = 122
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char = d;code = 100
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char = G;code = 71
char = S;code = 83
char = H;code = 72
char = ;code = 32
char = i;code = 105
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char = ;code = 32
char = b;code = 98
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char = ;code = 32
char = t;code = 116
char = h;code = 104
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char = d;code = 100
char = ;code = 32
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char = c;code = 99
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char = L;code = 76
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char = e;code = 101
char = x;code = 120
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char = c;code = 99
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char = e;code = 101
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char = e;code = 101
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char = p;code = 112
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char = f;code = 102
char = e;code = 101
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char = ;code = 32
char = m;code = 109
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char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = n;code = 110
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = t;code = 116
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char = u;code = 117
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char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = o;code = 111
char = p;code = 112
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char = o;code = 111
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result sql = In this study, we show that the novel synthetic curcumin analog, EF24, induces cell cycle arrest and apoptosis by means of a redox-dependent mechanism in MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells. Cell cycle analysis demonstrated that EF24 causes a G2/M arrest in both cell lines, and that this cell cycle arrest is followed by the induction of apoptosis as evidenced by caspase-3 activation, phosphatidylserine externalization and an increased number of cells with a sub-G1 DNA fraction. In addition, we demonstrate that EF24 induces a depolarization of the mitochondrial membrane potential, suggesting that the compound may also induce apoptosis by altering mitochondrial function. EF24, like curcumin, serves as a Michael acceptor reacting with glutathione (GSH) and thioredoxin 1. Reaction of EF24 with these agents in vivo significantly reduced intracellular GSH as well as oxidized GSH in both the wild-type and Bcl-xL overexpressing HT29 human colon cancer cells. We therefore propose that the anticancer effect of a novel curcumin analog, EF24, is mediated in part by redox-mediated induction of apoptosis.
char = F;code = 70
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char = 4;code = 52
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = ;code = 32
char = s;code = 115
char = y;code = 121
char = n;code = 110
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = r;code = 114
char = c;code = 99
char = u;code = 117
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = s;code = 115
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char = a;code = 97
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
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char = i;code = 105
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char = i;code = 105
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char = c;code = 99
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char = ;code = 32
char = a;code = 97
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = o;code = 111
char = x;code = 120
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char = d;code = 100
char = e;code = 101
char = p;code = 112
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char = n;code = 110
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = m;code = 109
char = .;code = 46
result sql = EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism.
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
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char = t;code = 116
char = u;code = 117
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char = s;code = 115
char = h;code = 104
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char = e;code = 101
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result sql = In this study, we show that the novel synthetic curcumin analog, EF24, induces cell cycle arrest and apoptosis by means of a redox-dependent mechanism in MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells. Cell cycle analysis demonstrated that EF24 causes a G2/M arrest in both cell lines, and that this cell cycle arrest is followed by the induction of apoptosis as evidenced by caspase-3 activation, phosphatidylserine externalization and an increased number of cells with a sub-G1 DNA fraction. In addition, we demonstrate that EF24 induces a depolarization of the mitochondrial membrane potential, suggesting that the compound may also induce apoptosis by altering mitochondrial function. EF24, like curcumin, serves as a Michael acceptor reacting with glutathione (GSH) and thioredoxin 1. Reaction of EF24 with these agents in vivo significantly reduced intracellular GSH as well as oxidized GSH in both the wild-type and Bcl-xL overexpressing HT29 human colon cancer cells. We therefore propose that the anticancer effect of a novel curcumin analog, EF24, is mediated in part by redox-mediated induction of apoptosis.
Publication: Anticancer Drugs 2005 Mar ;16(3)::263-75.
Publication Date: 2005 Mar
Study Author(s): Adams, Brian K;Cai, Jiyang;Armstrong, Jeff;Herold, Marike;Lu, Yang J;Sun, Aiming;Snyder, James P;Liotta, Dennis C;Jones, Dean P;Shoji, Mamoru;
Institution: Program in Molecular and Systems Pharmacology, Emory University, Atlanta, GA 30322, USA.
Shortcut link to this study:
Publication Date: 2005 Mar
Study Author(s): Adams, Brian K;Cai, Jiyang;Armstrong, Jeff;Herold, Marike;Lu, Yang J;Sun, Aiming;Snyder, James P;Liotta, Dennis C;Jones, Dean P;Shoji, Mamoru;
Institution: Program in Molecular and Systems Pharmacology, Emory University, Atlanta, GA 30322, USA.
Shortcut link to this study:
In this study, we show that the novel synthetic curcumin analog, EF24, induces cell cycle arrest and apoptosis by means of a redox-dependent mechanism in MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells. Cell cycle analysis demonstrated that EF24 causes a G2/M arrest in both cell lines, and that this cell cycle arrest is followed by the induction of apoptosis as evidenced by caspase-3 activation, phosphatidylserine externalization and an increased number of cells with a sub-G1 DNA fraction. In addition, we demonstrate that EF24 induces a depolarization of the mitochondrial membrane potential, suggesting that the compound may also induce apoptosis by altering mitochondrial function. EF24, like curcumin, serves as a Michael acceptor reacting with glutathione (GSH) and thioredoxin 1. Reaction of EF24 with these agents in vivo significantly reduced intracellular GSH as well as oxidized GSH in both the wild-type and Bcl-xL overexpressing HT29 human colon cancer cells. We therefore propose that the anticancer effect of a novel curcumin analog, EF24, is mediated in part by redox-mediated induction of apoptosis.
PMID: 15711178
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