|
|
char = G;code = 71
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char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = .;code = 46
result sql = Genistein-induced neuroendocrine differentiation of prostate cancer cells.
Genistein-induced neuroendocrine differentiation of prostate cancer cells.char = <;code = 60
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char = K;code = 75
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char = <;code = 60
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char = (;code = 40
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char = (;code = 40
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char = A;code = 65
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char = <;code = 60
char = b;code = 98
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char = H;code = 72
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char = :;code = 58
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char = <;code = 60
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char = L;code = 76
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char = C;code = 67
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char = W;code = 87
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char = s;code = 115
char = t;code = 116
char = e;code = 101
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char = n;code = 110
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char = ,;code = 44
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char = d;code = 100
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char = N;code = 78
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result sql = BACKGROUND : Neuroendocrine (NE) cells are present in normal prostate and their number appears to be increased in advanced prostate cancer (PCA). In this study, we studied the effect of the phytoestrogen, genistein, on NE differentiation of LNCaP cells in vitro.
METHODS : Neuroendocrine marker expression of LNCaP cells exposed to genistein was measured by immunohistochemistry, Western blot, and real-time PCR methods. Western blot analysis was used to study cell cycle and signaling pathways induced by genistein treatment.
RESULTS : Six days after continuous genistein treatment, the majority of genistein-surviving cancer cells underwent transdifferentiation into a NE-like phenotype overexpressing the NE markers chromogranin A, synaptophysin, serotonin, and beta-III tubulin. This NE differentiation process was associated with upregulation of the cell cycle modulators p21, p27, and p53, and activation of the MAPK and STAT3 pathways.
CONCLUSION : Our data indicate that genistein evokes not only apoptosis but also NE transdifferentiation of PCA cells.
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result sql = Genistein-induced neuroendocrine differentiation of prostate cancer cells.
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char = n;code = 110
char = g;code = 103
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = N;code = 78
char = E;code = 69
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = r;code = 114
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char = p;code = 112
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char = ,;code = 44
char = ;code = 32
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char = e;code = 101
char = r;code = 114
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char = o;code = 111
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char = i;code = 105
char = n;code = 110
char = ,;code = 44
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = -;code = 45
char = I;code = 73
char = I;code = 73
char = I;code = 73
char = ;code = 32
char = t;code = 116
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char = b;code = 98
char = u;code = 117
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char = i;code = 105
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char = s;code = 115
char = ;code = 32
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char = s;code = 115
char = s;code = 115
char = o;code = 111
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char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = u;code = 117
char = p;code = 112
char = r;code = 114
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char = g;code = 103
char = u;code = 117
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char = a;code = 97
char = t;code = 116
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char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = c;code = 99
char = l;code = 108
char = e;code = 101
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char = m;code = 109
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char = d;code = 100
char = u;code = 117
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char = a;code = 97
char = t;code = 116
char = o;code = 111
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char = s;code = 115
char = ;code = 32
char = p;code = 112
char = 2;code = 50
char = 1;code = 49
char = ,;code = 44
char = ;code = 32
char = p;code = 112
char = 2;code = 50
char = 7;code = 55
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = p;code = 112
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char = ;code = 32
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char = h;code = 104
char = e;code = 101
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char = A;code = 65
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char = A;code = 65
char = T;code = 84
char = 3;code = 51
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char = a;code = 97
char = y;code = 121
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char = <;code = 60
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char = r;code = 114
char = /;code = 47
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char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
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char = C;code = 67
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char = O;code = 79
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char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = e;code = 101
char = v;code = 118
char = o;code = 111
char = k;code = 107
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = b;code = 98
char = u;code = 117
char = t;code = 116
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
char = ;code = 32
char = N;code = 78
char = E;code = 69
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = d;code = 100
char = i;code = 105
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = P;code = 80
char = C;code = 67
char = A;code = 65
char = ;code = 32
char = c;code = 99
char = e;code = 101
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char = l;code = 108
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result sql = BACKGROUND : Neuroendocrine (NE) cells are present in normal prostate and their number appears to be increased in advanced prostate cancer (PCA). In this study, we studied the effect of the phytoestrogen, genistein, on NE differentiation of LNCaP cells in vitro.
METHODS : Neuroendocrine marker expression of LNCaP cells exposed to genistein was measured by immunohistochemistry, Western blot, and real-time PCR methods. Western blot analysis was used to study cell cycle and signaling pathways induced by genistein treatment.
RESULTS : Six days after continuous genistein treatment, the majority of genistein-surviving cancer cells underwent transdifferentiation into a NE-like phenotype overexpressing the NE markers chromogranin A, synaptophysin, serotonin, and beta-III tubulin. This NE differentiation process was associated with upregulation of the cell cycle modulators p21, p27, and p53, and activation of the MAPK and STAT3 pathways.
CONCLUSION : Our data indicate that genistein evokes not only apoptosis but also NE transdifferentiation of PCA cells.
Publication: Prostate 2006 Aug 1 ;66(11)::1136-43.
Publication Date: 2006 Aug 1
Study Author(s): Pinski, Jacek;Wang, Qingcai;Quek, Marcus L;Cole, Ariana;Cooc, Janine;Danenberg, Kathleen;Danenberg, Peter V;
Institution: Division of Medical Oncology, University of Southern California Keck School of Medicine, USC/Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA. [email protected]
Shortcut link to this study:
Publication Date: 2006 Aug 1
Study Author(s): Pinski, Jacek;Wang, Qingcai;Quek, Marcus L;Cole, Ariana;Cooc, Janine;Danenberg, Kathleen;Danenberg, Peter V;
Institution: Division of Medical Oncology, University of Southern California Keck School of Medicine, USC/Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA. [email protected]
Shortcut link to this study:
BACKGROUND : Neuroendocrine (NE) cells are present in normal prostate and their number appears to be increased in advanced prostate cancer (PCA). In this study, we studied the effect of the phytoestrogen, genistein, on NE differentiation of LNCaP cells in vitro.
METHODS : Neuroendocrine marker expression of LNCaP cells exposed to genistein was measured by immunohistochemistry, Western blot, and real-time PCR methods. Western blot analysis was used to study cell cycle and signaling pathways induced by genistein treatment.
RESULTS : Six days after continuous genistein treatment, the majority of genistein-surviving cancer cells underwent transdifferentiation into a NE-like phenotype overexpressing the NE markers chromogranin A, synaptophysin, serotonin, and beta-III tubulin. This NE differentiation process was associated with upregulation of the cell cycle modulators p21, p27, and p53, and activation of the MAPK and STAT3 pathways.
CONCLUSION : Our data indicate that genistein evokes not only apoptosis but also NE transdifferentiation of PCA cells.
METHODS : Neuroendocrine marker expression of LNCaP cells exposed to genistein was measured by immunohistochemistry, Western blot, and real-time PCR methods. Western blot analysis was used to study cell cycle and signaling pathways induced by genistein treatment.
RESULTS : Six days after continuous genistein treatment, the majority of genistein-surviving cancer cells underwent transdifferentiation into a NE-like phenotype overexpressing the NE markers chromogranin A, synaptophysin, serotonin, and beta-III tubulin. This NE differentiation process was associated with upregulation of the cell cycle modulators p21, p27, and p53, and activation of the MAPK and STAT3 pathways.
CONCLUSION : Our data indicate that genistein evokes not only apoptosis but also NE transdifferentiation of PCA cells.
PMID: 16652383
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