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result sql = Growth inhibition and apoptosis inducing mechanisms of curcumin on human ovarian cancer cell line A2780.
Growth inhibition and apoptosis inducing mechanisms of curcumin on human ovarian cancer cell line A2780.
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char = ;code = 32
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char = p;code = 112
char = p;code = 112
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char = a;code = 97
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char = <;code = 60
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char = >;code = 62
char = <;code = 60
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char = L;code = 76
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char = S;code = 83
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char = O;code = 79
char = N;code = 78
char = ;code = 32
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char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = C;code = 67
char = u;code = 117
char = r;code = 114
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char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = c;code = 99
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char = u;code = 117
char = l;code = 108
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char = ;code = 32
char = s;code = 115
char = i;code = 105
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char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
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char = n;code = 110
char = t;code = 116
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char = ;code = 32
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char = n;code = 110
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char = b;code = 98
char = i;code = 105
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char = e;code = 101
char = ;code = 32
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char = o;code = 111
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char = m;code = 109
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char = o;code = 111
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char = r;code = 114
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char = a;code = 97
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char = c;code = 99
char = a;code = 97
char = n;code = 110
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char = n;code = 110
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char = p;code = 112
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char = h;code = 104
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char = a;code = 97
char = t;code = 116
char = i;code = 105
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char = g;code = 103
char = ;code = 32
char = g;code = 103
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char = e;code = 101
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char = r;code = 114
char = e;code = 101
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char = s;code = 115
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char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
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char = ;code = 32
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char = a;code = 97
char = p;code = 112
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char = r;code = 114
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char = b;code = 98
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = i;code = 105
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = c;code = 99
char = h;code = 104
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char = n;code = 110
char = i;code = 105
char = s;code = 115
char = m;code = 109
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result sql = OBJECTIVE : To explore the growth inhibition effects and apoptosis inducing mechanisms of curcumin on human ovarian cancer cell line A2780.

METHODS : After treatment with 10 - 50 micromol/L curcumin for 6 - 24 h, the growth activity of A2780 cancer cells were studied by [4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) colorimetry. Cellular apoptosis was inspected by flow cytometery and acridine orange-ethidium bromide fluorescent staining methods. The fragmentation of cellular chromosome DNA was detected by DNA ladder, the ultrastructural change was observed under a transmission electron microscope, and the protein levels of nuclear factor-kappa B (NF-kappaB, P65) and cysteinyl aspartate specific protease-3 (Caspase-3) in ovarian cancer cells were measured by immunohistochemistry.

RESULTS : After treatment with various concentrations of curcumin, the growth inhibition rates of cancer cells reached 62.05% - 89.24%, with sub-G(1) peaks appearing on histogram. Part of the cancer cells showed characteristic morphological changes of apoptosis under fluorescence and electron microscopes, and the rate of apoptosis was 21.5% - 33.5%. The protein expression of NF-kappaB was decreased, while that of Caspase-3 was increased in a time-dependent manner.

CONCLUSION : Curcumin could significantly inhibit the growth of human ovarian cancer cells; inducing apoptosis through up-regulating Caspase-3 and down-regulating gene expression of NF-kappaB is probably one of its molecular mechanisms.

Publication: Chin J Integr Med 2006 Jun ;12(2)::126-31.
Publication Date: 2006 Jun
Study Author(s): Zheng, Li-duan;Tong, Qiang-song;Wu, Cui-huan;
Institution: Department of Pathology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. [email protected]
Shortcut link to this study:
OBJECTIVE : To explore the growth inhibition effects and apoptosis inducing mechanisms of curcumin on human ovarian cancer cell line A2780.

METHODS : After treatment with 10 - 50 micromol/L curcumin for 6 - 24 h, the growth activity of A2780 cancer cells were studied by [4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) colorimetry. Cellular apoptosis was inspected by flow cytometery and acridine orange-ethidium bromide fluorescent staining methods. The fragmentation of cellular chromosome DNA was detected by DNA ladder, the ultrastructural change was observed under a transmission electron microscope, and the protein levels of nuclear factor-kappa B (NF-kappaB, P65) and cysteinyl aspartate specific protease-3 (Caspase-3) in ovarian cancer cells were measured by immunohistochemistry.

RESULTS : After treatment with various concentrations of curcumin, the growth inhibition rates of cancer cells reached 62.05% - 89.24%, with sub-G(1) peaks appearing on histogram. Part of the cancer cells showed characteristic morphological changes of apoptosis under fluorescence and electron microscopes, and the rate of apoptosis was 21.5% - 33.5%. The protein expression of NF-kappaB was decreased, while that of Caspase-3 was increased in a time-dependent manner.

CONCLUSION : Curcumin could significantly inhibit the growth of human ovarian cancer cells; inducing apoptosis through up-regulating Caspase-3 and down-regulating gene expression of NF-kappaB is probably one of its molecular mechanisms.
PMID: 16800992

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