|
|
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result sql = AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells.
AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells.char = A;code = 65
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result sql = AMP-activated protein kinase (AMPK), an evolutionarily conserved serine/threonine protein kinase, serves as an energy sensor in all eukaryotic cells. Recent findings suggest that AMPK activation strongly suppresses cell proliferation and induces cell apoptosis in a variety of cancer cells. Our study demonstrated that chemopreventive agent curcumin strongly activates AMPK in a p38-dependent manner in CaOV3 ovarian cancer cells. Pretreatment of cells with compound C (AMPK inhibitor) and SB203580 (p38 inhibitor) attenuates curcumin-induced cell death. We also observed that curcumin induces p53 phosphorylation (Ser 15) and both compound C and SB203580 pretreatment inhibit p53 phosphorylation. Collectively, our data suggest that AMPK is a new molecular target of curcumin and AMPK activation partially contributes to the cytotoxic effect of curcumin in ovarian cancer cells.
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result sql = AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells.
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result sql = AMP-activated protein kinase (AMPK), an evolutionarily conserved serine/threonine protein kinase, serves as an energy sensor in all eukaryotic cells. Recent findings suggest that AMPK activation strongly suppresses cell proliferation and induces cell apoptosis in a variety of cancer cells. Our study demonstrated that chemopreventive agent curcumin strongly activates AMPK in a p38-dependent manner in CaOV3 ovarian cancer cells. Pretreatment of cells with compound C (AMPK inhibitor) and SB203580 (p38 inhibitor) attenuates curcumin-induced cell death. We also observed that curcumin induces p53 phosphorylation (Ser 15) and both compound C and SB203580 pretreatment inhibit p53 phosphorylation. Collectively, our data suggest that AMPK is a new molecular target of curcumin and AMPK activation partially contributes to the cytotoxic effect of curcumin in ovarian cancer cells.
Publication: Oncol. Rep. 2008 Dec ;20(6)::1553-9.
Publication Date: 2008 Dec
Study Author(s): Pan, Wei;Yang, Hui;Cao, Cong;Song, Xiuzu;Wallin, Brittany;Kivlin, Rebecca;Lu, Shan;Hu, Gang;Di, Wen;Wan, Yinsheng;
Institution: Department of Biology, Providence College, Providence, RI 02908, USA.
Shortcut link to this study:
Publication Date: 2008 Dec
Study Author(s): Pan, Wei;Yang, Hui;Cao, Cong;Song, Xiuzu;Wallin, Brittany;Kivlin, Rebecca;Lu, Shan;Hu, Gang;Di, Wen;Wan, Yinsheng;
Institution: Department of Biology, Providence College, Providence, RI 02908, USA.
Shortcut link to this study:
AMP-activated protein kinase (AMPK), an evolutionarily conserved serine/threonine protein kinase, serves as an energy sensor in all eukaryotic cells. Recent findings suggest that AMPK activation strongly suppresses cell proliferation and induces cell apoptosis in a variety of cancer cells. Our study demonstrated that chemopreventive agent curcumin strongly activates AMPK in a p38-dependent manner in CaOV3 ovarian cancer cells. Pretreatment of cells with compound C (AMPK inhibitor) and SB203580 (p38 inhibitor) attenuates curcumin-induced cell death. We also observed that curcumin induces p53 phosphorylation (Ser 15) and both compound C and SB203580 pretreatment inhibit p53 phosphorylation. Collectively, our data suggest that AMPK is a new molecular target of curcumin and AMPK activation partially contributes to the cytotoxic effect of curcumin in ovarian cancer cells.
PMID: 19020741
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