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result sql = Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model.
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result sql = Curcumin, a well-known dietary pigment derived from Curcuma longa, inhibited growth of several types of malignant cells both in vivo and in vitro. Its effects on cell proliferation and the induction of apoptosis in human bladder cancer cell lines and intravesical activity in a rat bladder tumor model were studied. Exposure of human bladder cancer cells to curcumin resulted in the induction of apoptotic cell death and caused cells to arrest in the G2/M phase. The anti-apoptotic Bcl-2 and Survivin protein was downregulated by the curcumin treatment together with enhancement of the Bax and p53 expression. The inhibitory activities of curcumin were stronger than those of cisplatin and could not be prevented by catalase pretreatment in T24 cells. Clonal assay indicated large-dose and short-term curcumin was lethal to bladder cancer cells. Moreover, the in vivo study revealed curcumin did induce apoptosis in situ, inhibit and slow the development of bladder cancer. These observations suggest that curcumin could prove an effective chemopreventive and chemotherapy agent for bladder cancer.
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char = ;code = 32
char = c;code = 99
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char = r;code = 114
char = c;code = 99
char = u;code = 117
char = m;code = 109
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char = ;code = 32
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char = d;code = 100
char = d;code = 100
char = e;code = 101
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char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = d;code = 100
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char = e;code = 101
char = l;code = 108
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char = d;code = 100
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char = ;code = 32
char = m;code = 109
char = o;code = 111
char = d;code = 100
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char = .;code = 46
result sql = Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model.
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result sql = Curcumin, a well-known dietary pigment derived from Curcuma longa, inhibited growth of several types of malignant cells both in vivo and in vitro. Its effects on cell proliferation and the induction of apoptosis in human bladder cancer cell lines and intravesical activity in a rat bladder tumor model were studied. Exposure of human bladder cancer cells to curcumin resulted in the induction of apoptotic cell death and caused cells to arrest in the G2/M phase. The anti-apoptotic Bcl-2 and Survivin protein was downregulated by the curcumin treatment together with enhancement of the Bax and p53 expression. The inhibitory activities of curcumin were stronger than those of cisplatin and could not be prevented by catalase pretreatment in T24 cells. Clonal assay indicated large-dose and short-term curcumin was lethal to bladder cancer cells. Moreover, the in vivo study revealed curcumin did induce apoptosis in situ, inhibit and slow the development of bladder cancer. These observations suggest that curcumin could prove an effective chemopreventive and chemotherapy agent for bladder cancer.
Publication: Cancer Lett. 2008 Jun 18 ;264(2)::299-308. :doi: 10.1016/j.canlet.2008.01.041.
Publication Date: 2008 Jun 18
Study Author(s): Tian, Binqiang;Wang, Zhiping;Zhao, Yingmei;Wang, Degui;Li, Yonggang;Ma, Li;Li, Xiaoming;Li, Jing;Xiao, Nan;Tian, Junqiang;Rodriguez, Ronald;
Institution: Institute of Urology, Second Hospital, Lanzhou University, 80 Cuiyingmen Street, Lanzhou, Gansu 730030, China.
Shortcut link to this study:
Publication Date: 2008 Jun 18
Study Author(s): Tian, Binqiang;Wang, Zhiping;Zhao, Yingmei;Wang, Degui;Li, Yonggang;Ma, Li;Li, Xiaoming;Li, Jing;Xiao, Nan;Tian, Junqiang;Rodriguez, Ronald;
Institution: Institute of Urology, Second Hospital, Lanzhou University, 80 Cuiyingmen Street, Lanzhou, Gansu 730030, China.
Shortcut link to this study:
Curcumin, a well-known dietary pigment derived from Curcuma longa, inhibited growth of several types of malignant cells both in vivo and in vitro. Its effects on cell proliferation and the induction of apoptosis in human bladder cancer cell lines and intravesical activity in a rat bladder tumor model were studied. Exposure of human bladder cancer cells to curcumin resulted in the induction of apoptotic cell death and caused cells to arrest in the G2/M phase. The anti-apoptotic Bcl-2 and Survivin protein was downregulated by the curcumin treatment together with enhancement of the Bax and p53 expression. The inhibitory activities of curcumin were stronger than those of cisplatin and could not be prevented by catalase pretreatment in T24 cells. Clonal assay indicated large-dose and short-term curcumin was lethal to bladder cancer cells. Moreover, the in vivo study revealed curcumin did induce apoptosis in situ, inhibit and slow the development of bladder cancer. These observations suggest that curcumin could prove an effective chemopreventive and chemotherapy agent for bladder cancer.
PMID: 18342436
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