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char = c;code = 99
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char = p;code = 112
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
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char = .;code = 46
result sql = Mechanism of alpha-lipoic acid-induced apoptosis of lung cancer cells.
Mechanism of alpha-lipoic acid-induced apoptosis of lung cancer cells.
char = A;code = 65
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char = c;code = 99
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char = d;code = 100
char = ;code = 32
char = (;code = 40
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char = A;code = 65
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char = w;code = 119
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
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char = e;code = 101
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char = f;code = 102
char = e;code = 101
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char = o;code = 111
char = n;code = 110
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char = s;code = 115
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char = o;code = 111
char = p;code = 112
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
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char = .;code = 46
char = ;code = 32
char = I;code = 73
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char = t;code = 116
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
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char = C;code = 67
char = a;code = 97
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char = g;code = 103
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char = a;code = 97
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char = o;code = 111
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char = i;code = 105
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char = a;code = 97
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char = h;code = 104
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char = s;code = 115
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char = i;code = 105
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char = l;code = 108
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char = h;code = 104
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = C;code = 67
char = a;code = 97
char = (;code = 40
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char = );code = 41
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char = i;code = 105
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char = L;code = 76
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char = a;code = 97
char = b;code = 98
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char = y;code = 121
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char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = D;code = 68
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result sql = Alpha-lipoic acid (LA) shows a protective effect on oxidative stress-induced apoptosis while it induces apoptosis in various cancer cells. Intracellular Ca(2+) plays a central role in triggering apoptotic pathways. In the present study, we aim to investigate whether LA induces apoptosis in lung cancer cells and whether Ca(2+) is involved in LA-induced apoptosis. We found that LA decreased cell viability and increased DNA fragmentation of the cells. LA activated the caspase-independent pathway, determined by upregulation of poly(ADP-ribose) polymerase (PARP) and increased the nuclear level of apoptosis-inducing factor and caspase-dependent apoptotic pathway, determined by increased levels of cytochrome c and PARP-1 cleavage product. LA-induced apoptotic alterations were inhibited in the cells treated with Ca(2+) chelator BAPTA-AM. In conclusion, LA induces apoptosis through caspase-independent and caspase-dependent pathways, which is mediated by intracellular Ca(2+).

Publication: Ann. N. Y. Acad. Sci. 2009 Aug ;1171:149-55. :doi: 10.1111/j.1749-6632.2009.04708.x.
Publication Date: 2009 Aug
Study Author(s): Choi, Sang Yong;Yu, Ji Hoon;Kim, Hyeyoung;
Institution: Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University College of Human Ecology, Seoul, Korea.
Shortcut link to this study:
Alpha-lipoic acid (LA) shows a protective effect on oxidative stress-induced apoptosis while it induces apoptosis in various cancer cells. Intracellular Ca(2+) plays a central role in triggering apoptotic pathways. In the present study, we aim to investigate whether LA induces apoptosis in lung cancer cells and whether Ca(2+) is involved in LA-induced apoptosis. We found that LA decreased cell viability and increased DNA fragmentation of the cells. LA activated the caspase-independent pathway, determined by upregulation of poly(ADP-ribose) polymerase (PARP) and increased the nuclear level of apoptosis-inducing factor and caspase-dependent apoptotic pathway, determined by increased levels of cytochrome c and PARP-1 cleavage product. LA-induced apoptotic alterations were inhibited in the cells treated with Ca(2+) chelator BAPTA-AM. In conclusion, LA induces apoptosis through caspase-independent and caspase-dependent pathways, which is mediated by intracellular Ca(2+).
PMID: 19723049

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