|
|
char = C;code = 67
char = u;code = 117
char = r;code = 114
char = c;code = 99
char = u;code = 117
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = F;code = 70
char = O;code = 79
char = L;code = 76
char = F;code = 70
char = O;code = 79
char = X;code = 88
char = -;code = 45
char = s;code = 115
char = u;code = 117
char = r;code = 114
char = v;code = 118
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = a;code = 97
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = E;code = 69
char = G;code = 71
char = F;code = 70
char = R;code = 82
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = I;code = 73
char = G;code = 71
char = F;code = 70
char = -;code = 45
char = 1;code = 49
char = R;code = 82
char = .;code = 46
result sql = Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R.
Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R.char = C;code = 67
char = u;code = 117
char = r;code = 114
char = c;code = 99
char = u;code = 117
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = (;code = 40
char = d;code = 100
char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = u;code = 117
char = l;code = 108
char = o;code = 111
char = y;code = 121
char = l;code = 108
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = e;code = 101
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = w;code = 119
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char = i;code = 105
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char = ;code = 32
char = h;code = 104
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char = o;code = 111
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char = d;code = 100
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char = s;code = 115
char = c;code = 99
char = e;code = 101
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char = i;code = 105
char = b;code = 98
char = l;code = 108
char = e;code = 101
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char = t;code = 116
char = o;code = 111
char = x;code = 120
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char = c;code = 99
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char = t;code = 116
char = y;code = 121
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char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
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char = t;code = 116
char = s;code = 115
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char = i;code = 105
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char = i;code = 105
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char = m;code = 109
char = o;code = 111
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char = d;code = 100
char = ;code = 32
char = p;code = 112
char = r;code = 114
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char = g;code = 103
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = c;code = 99
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char = g;code = 103
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char = e;code = 101
char = s;code = 115
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char = s;code = 115
char = .;code = 46
char = ;code = 32
char = 5;code = 53
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char = F;code = 70
char = l;code = 108
char = u;code = 117
char = o;code = 111
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = i;code = 105
char = l;code = 108
char = ;code = 32
char = (;code = 40
char = 5;code = 53
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char = F;code = 70
char = U;code = 85
char = );code = 41
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = 5;code = 53
char = -;code = 45
char = F;code = 70
char = U;code = 85
char = ;code = 32
char = p;code = 112
char = l;code = 108
char = u;code = 117
char = s;code = 115
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char = o;code = 111
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char = i;code = 105
char = p;code = 112
char = l;code = 108
char = a;code = 97
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char = n;code = 110
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char = (;code = 40
char = F;code = 70
char = O;code = 79
char = L;code = 76
char = F;code = 70
char = O;code = 79
char = X;code = 88
char = );code = 41
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = m;code = 109
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = b;code = 98
char = a;code = 97
char = c;code = 99
char = k;code = 107
char = b;code = 98
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char = o;code = 111
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char = c;code = 99
char = o;code = 111
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char = o;code = 111
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char = e;code = 101
char = c;code = 99
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char = ;code = 32
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char = n;code = 110
char = c;code = 99
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char = r;code = 114
char = ;code = 32
char = c;code = 99
char = h;code = 104
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char = m;code = 109
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char = r;code = 114
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char = (;code = 40
char = c;code = 99
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char = i;code = 105
char = v;code = 118
char = i;code = 105
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char = g;code = 103
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char = c;code = 99
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char = l;code = 108
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char = ;code = 32
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char = r;code = 114
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char = e;code = 101
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = t;code = 116
char = i;code = 105
char = g;code = 103
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char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = u;code = 117
char = n;code = 110
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char = a;code = 97
char = k;code = 107
char = e;code = 101
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char = e;code = 101
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char = w;code = 119
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char = e;code = 101
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char = h;code = 104
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char = d;code = 100
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char = o;code = 111
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char = ;code = 32
char = c;code = 99
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char = r;code = 114
char = c;code = 99
char = u;code = 117
char = m;code = 109
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char = ;code = 32
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char = o;code = 111
char = ;code = 32
char = F;code = 70
char = O;code = 79
char = L;code = 76
char = F;code = 70
char = O;code = 79
char = X;code = 88
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char = a;code = 97
char = ;code = 32
char = s;code = 115
char = u;code = 117
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char = r;code = 114
char = i;code = 105
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
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char = r;code = 114
char = a;code = 97
char = p;code = 112
char = e;code = 101
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = s;code = 115
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char = r;code = 114
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char = t;code = 116
char = e;code = 101
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char = y;code = 121
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char = f;code = 102
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char = c;code = 99
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char = e;code = 101
char = m;code = 109
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char = i;code = 105
char = v;code = 118
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char = ;code = 32
char = c;code = 99
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char = .;code = 46
char = ;code = 32
char = F;code = 70
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char = e;code = 101
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char = m;code = 109
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char = H;code = 72
char = C;code = 67
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char = 1;code = 49
char = 1;code = 49
char = 6;code = 54
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char = c;code = 99
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char = e;code = 101
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char = o;code = 111
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char = o;code = 111
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char = ;code = 32
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char = H;code = 72
char = E;code = 69
char = R;code = 82
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char = l;code = 108
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char = a;code = 97
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char = t;code = 116
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char = y;code = 121
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char = m;code = 109
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char = r;code = 114
char = a;code = 97
char = l;code = 108
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char = o;code = 111
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char = c;code = 99
char = o;code = 111
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char = e;code = 101
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char = e;code = 101
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char = m;code = 109
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = g;code = 103
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char = 1;code = 49
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char = (;code = 40
char = A;code = 65
char = K;code = 75
char = T;code = 84
char = );code = 41
char = ,;code = 44
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char = c;code = 99
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char = c;code = 99
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char = o;code = 111
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char = a;code = 97
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char = 2;code = 50
char = ;code = 32
char = (;code = 40
char = C;code = 67
char = O;code = 79
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char = a;code = 97
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char = c;code = 99
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char = D;code = 68
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char = ;code = 32
char = H;code = 72
char = o;code = 111
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char = e;code = 101
char = v;code = 118
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char = r;code = 114
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char = i;code = 105
char = n;code = 110
char = c;code = 99
char = l;code = 108
char = u;code = 117
char = s;code = 115
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char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
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char = r;code = 114
char = c;code = 99
char = u;code = 117
char = m;code = 109
char = i;code = 105
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char = t;code = 116
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char = c;code = 99
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char = n;code = 110
char = t;code = 116
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char = n;code = 110
char = u;code = 117
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = F;code = 70
char = O;code = 79
char = L;code = 76
char = F;code = 70
char = O;code = 79
char = X;code = 88
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
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char = t;code = 116
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char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = a;code = 97
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = 4;code = 52
char = 8;code = 56
char = ;code = 32
char = h;code = 104
char = ;code = 32
char = g;code = 103
char = r;code = 114
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char = a;code = 97
char = t;code = 116
char = l;code = 108
char = y;code = 121
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char = r;code = 114
char = e;code = 101
char = d;code = 100
char = u;code = 117
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
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char = e;code = 101
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char = s;code = 115
char = u;code = 117
char = r;code = 114
char = v;code = 118
char = i;code = 105
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = o;code = 111
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = c;code = 99
char = e;code = 101
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char = l;code = 108
char = s;code = 115
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char = c;code = 99
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = b;code = 98
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char = a;code = 97
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char = c;code = 99
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char = c;code = 99
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char = m;code = 109
char = i;code = 105
char = t;code = 116
char = a;code = 97
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char = t;code = 116
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char = d;code = 100
char = u;code = 117
char = c;code = 99
char = t;code = 116
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char = o;code = 111
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char = n;code = 110
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char = a;code = 97
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char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = E;code = 69
char = G;code = 71
char = F;code = 70
char = R;code = 82
char = ,;code = 44
char = ;code = 32
char = H;code = 72
char = E;code = 69
char = R;code = 82
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char = 2;code = 50
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char = ;code = 32
char = I;code = 73
char = G;code = 71
char = F;code = 70
char = -;code = 45
char = 1;code = 49
char = R;code = 82
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = A;code = 65
char = K;code = 75
char = T;code = 84
char = ,;code = 44
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char = a;code = 97
char = s;code = 115
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char = w;code = 119
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char = l;code = 108
char = l;code = 108
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char = r;code = 114
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char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = C;code = 67
char = O;code = 79
char = X;code = 88
char = -;code = 45
char = 2;code = 50
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char = a;code = 97
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char = c;code = 99
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char = i;code = 105
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char = D;code = 68
char = 1;code = 49
char = .;code = 46
char = ;code = 32
char = M;code = 77
char = o;code = 111
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char = e;code = 101
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char = i;code = 105
char = m;code = 109
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char = E;code = 69
char = G;code = 71
char = F;code = 70
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char = o;code = 111
char = s;code = 115
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char = i;code = 105
char = b;code = 98
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char = a;code = 97
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char = t;code = 116
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char = o;code = 111
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char = o;code = 111
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char = ;code = 32
char = I;code = 73
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char = F;code = 70
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char = 1;code = 49
char = R;code = 82
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = r;code = 114
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char = s;code = 115
char = s;code = 115
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char = o;code = 111
char = n;code = 110
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char = b;code = 98
char = y;code = 121
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char = h;code = 104
char = e;code = 101
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char = c;code = 99
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char = g;code = 103
char = ;code = 32
char = s;code = 115
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char = -;code = 45
char = R;code = 82
char = N;code = 78
char = A;code = 65
char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = s;code = 115
char = e;code = 101
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char = a;code = 97
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char = 3;code = 51
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char = 6;code = 54
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char = %;code = 37
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char = o;code = 111
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char = t;code = 116
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char = b;code = 98
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char = o;code = 111
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char = c;code = 99
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char = e;code = 101
char = m;code = 109
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char = r;code = 114
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char = i;code = 105
char = v;code = 118
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char = n;code = 110
char = g;code = 103
char = ;code = 32
char = H;code = 72
char = C;code = 67
char = T;code = 84
char = -;code = 45
char = 1;code = 49
char = 1;code = 49
char = 6;code = 54
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = .;code = 46
char = ;code = 32
char = H;code = 72
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char = e;code = 101
char = v;code = 118
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char = b;code = 98
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char = G;code = 71
char = F;code = 70
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char = 1;code = 49
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char = s;code = 115
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char = R;code = 82
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char = H;code = 72
char = C;code = 67
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char = -;code = 45
char = 1;code = 49
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char = ;code = 32
char = F;code = 70
char = O;code = 79
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char = F;code = 70
char = O;code = 79
char = X;code = 88
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char = t;code = 116
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char = O;code = 79
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char = d;code = 100
char = a;code = 97
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char = a;code = 97
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char = c;code = 99
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char = g;code = 103
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result sql = Curcumin (diferuloylmethane), which has no discernible toxicity, inhibits initiation, promotion and progression of carcinogenesis. 5-Fluorouracil (5-FU) or 5-FU plus oxaliplatin (FOLFOX) remains the backbone of colorectal cancer chemotherapeutics, but produces an incomplete response resulting in survival of cells (chemo-surviving cells) that may lead to cancer recurrence. The present investigation was, therefore, undertaken to examine whether addition of curcumin to FOLFOX is a superior therapeutic strategy for chemo-surviving cells. Forty-eight-hour treatment of colon cancer HCT-116 and HT-29 cells with FOLFOX resulted in 60-70% survival, accompanied by a marked activation of insulin like growth factor-1 receptor (IGF-1R) and minor to moderate increase in epidermal growth factor receptor (EGFR), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (HER-2) as well as v-akt murine thymoma viral oncogene homolog 1 (AKT), cyclooxygenase-2 (COX-2) and cyclin-D1. However, inclusion of curcumin to continued FOLFOX treatment for another 48 h greatly reduced the survival of these cells, accompanied by a concomitant reduction in activation of EGFR, HER-2, IGF-1R and AKT, as well as expression of COX-2 and cyclin-D1. More importantly, EGFR tyrosine kinase inhibitor gefitinib or attenuation of IGF-1R expression by the corresponding si-RNA caused a 30-60% growth inhibition of chemo-surviving HCT-116 cells. However, curcumin alone was found to be more effective than both gefitinib and IGF-1R si-RNA mediated growth inhibition of chemo-surviving HCT-116 cells and addition of FOLFOX to curcumin did not increase the growth inhibitory effect of curcumin. Our data suggest that inclusion of curcumin in conventional chemotherapeutic regimens could be an effective strategy to prevent the emergence of chemoresistant colon cancer cells.
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result sql = Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R.
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char = o;code = 111
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char = l;code = 108
char = i;code = 105
char = k;code = 107
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char = r;code = 114
char = o;code = 111
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char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
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char = 1;code = 49
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char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
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char = r;code = 114
char = ;code = 32
char = (;code = 40
char = I;code = 73
char = G;code = 71
char = F;code = 70
char = -;code = 45
char = 1;code = 49
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = m;code = 109
char = i;code = 105
char = n;code = 110
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char = t;code = 116
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char = m;code = 109
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char = d;code = 100
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char = r;code = 114
char = a;code = 97
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char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = e;code = 101
char = p;code = 112
char = i;code = 105
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char = a;code = 97
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char = r;code = 114
char = o;code = 111
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char = t;code = 116
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char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
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char = r;code = 114
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char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = r;code = 114
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char = (;code = 40
char = E;code = 69
char = G;code = 71
char = F;code = 70
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char = ,;code = 44
char = ;code = 32
char = v;code = 118
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char = b;code = 98
char = 2;code = 50
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char = r;code = 114
char = y;code = 121
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char = r;code = 114
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char = b;code = 98
char = l;code = 108
char = a;code = 97
char = s;code = 115
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char = i;code = 105
char = c;code = 99
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char = l;code = 108
char = e;code = 101
char = u;code = 117
char = k;code = 107
char = e;code = 101
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char = i;code = 105
char = a;code = 97
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char = v;code = 118
char = i;code = 105
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = o;code = 111
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char = c;code = 99
char = o;code = 111
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char = e;code = 101
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char = e;code = 101
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char = h;code = 104
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char = m;code = 109
char = o;code = 111
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char = o;code = 111
char = g;code = 103
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char = 2;code = 50
char = ;code = 32
char = (;code = 40
char = H;code = 72
char = E;code = 69
char = R;code = 82
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char = 2;code = 50
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char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = w;code = 119
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = s;code = 115
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char = v;code = 118
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char = a;code = 97
char = k;code = 107
char = t;code = 116
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = y;code = 121
char = m;code = 109
char = o;code = 111
char = m;code = 109
char = a;code = 97
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char = v;code = 118
char = i;code = 105
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = o;code = 111
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char = c;code = 99
char = o;code = 111
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char = e;code = 101
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char = e;code = 101
char = ;code = 32
char = h;code = 104
char = o;code = 111
char = m;code = 109
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = ;code = 32
char = 1;code = 49
char = ;code = 32
char = (;code = 40
char = A;code = 65
char = K;code = 75
char = T;code = 84
char = );code = 41
char = ,;code = 44
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char = c;code = 99
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char = c;code = 99
char = l;code = 108
char = o;code = 111
char = o;code = 111
char = x;code = 120
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char = g;code = 103
char = e;code = 101
char = n;code = 110
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = 2;code = 50
char = ;code = 32
char = (;code = 40
char = C;code = 67
char = O;code = 79
char = X;code = 88
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char = 2;code = 50
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = c;code = 99
char = l;code = 108
char = i;code = 105
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char = D;code = 68
char = 1;code = 49
char = .;code = 46
char = ;code = 32
char = H;code = 72
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = r;code = 114
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char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = l;code = 108
char = u;code = 117
char = s;code = 115
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char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
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char = r;code = 114
char = c;code = 99
char = u;code = 117
char = m;code = 109
char = i;code = 105
char = n;code = 110
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char = t;code = 116
char = o;code = 111
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char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = u;code = 117
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = F;code = 70
char = O;code = 79
char = L;code = 76
char = F;code = 70
char = O;code = 79
char = X;code = 88
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = a;code = 97
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = 4;code = 52
char = 8;code = 56
char = ;code = 32
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char = g;code = 103
char = r;code = 114
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char = a;code = 97
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char = l;code = 108
char = y;code = 121
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char = u;code = 117
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char = e;code = 101
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char = e;code = 101
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char = s;code = 115
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char = v;code = 118
char = a;code = 97
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char = ;code = 32
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char = h;code = 104
char = e;code = 101
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char = e;code = 101
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char = c;code = 99
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char = e;code = 101
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char = a;code = 97
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char = o;code = 111
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char = ;code = 32
char = E;code = 69
char = G;code = 71
char = F;code = 70
char = R;code = 82
char = ,;code = 44
char = ;code = 32
char = H;code = 72
char = E;code = 69
char = R;code = 82
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char = 2;code = 50
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char = ;code = 32
char = I;code = 73
char = G;code = 71
char = F;code = 70
char = -;code = 45
char = 1;code = 49
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char = ;code = 32
char = a;code = 97
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char = A;code = 65
char = K;code = 75
char = T;code = 84
char = ,;code = 44
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char = a;code = 97
char = s;code = 115
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char = w;code = 119
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char = l;code = 108
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char = a;code = 97
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char = e;code = 101
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char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = C;code = 67
char = O;code = 79
char = X;code = 88
char = -;code = 45
char = 2;code = 50
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char = a;code = 97
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char = c;code = 99
char = y;code = 121
char = c;code = 99
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char = n;code = 110
char = -;code = 45
char = D;code = 68
char = 1;code = 49
char = .;code = 46
char = ;code = 32
char = M;code = 77
char = o;code = 111
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char = e;code = 101
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char = i;code = 105
char = m;code = 109
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char = E;code = 69
char = G;code = 71
char = F;code = 70
char = R;code = 82
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char = t;code = 116
char = y;code = 121
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char = o;code = 111
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char = i;code = 105
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char = k;code = 107
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char = a;code = 97
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char = e;code = 101
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char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
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char = e;code = 101
char = f;code = 102
char = i;code = 105
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char = i;code = 105
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char = i;code = 105
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char = a;code = 97
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char = t;code = 116
char = e;code = 101
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char = u;code = 117
char = a;code = 97
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char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = I;code = 73
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char = F;code = 70
char = -;code = 45
char = 1;code = 49
char = R;code = 82
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = r;code = 114
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char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = b;code = 98
char = y;code = 121
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char = t;code = 116
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char = e;code = 101
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char = c;code = 99
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char = g;code = 103
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char = s;code = 115
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char = -;code = 45
char = R;code = 82
char = N;code = 78
char = A;code = 65
char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = s;code = 115
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char = v;code = 118
char = i;code = 105
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char = H;code = 72
char = C;code = 67
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char = -;code = 45
char = 1;code = 49
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char = 6;code = 54
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char = l;code = 108
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char = .;code = 46
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char = e;code = 101
char = v;code = 118
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char = b;code = 98
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char = f;code = 102
char = f;code = 102
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char = a;code = 97
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char = g;code = 103
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char = b;code = 98
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char = a;code = 97
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char = I;code = 73
char = G;code = 71
char = F;code = 70
char = -;code = 45
char = 1;code = 49
char = R;code = 82
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = -;code = 45
char = R;code = 82
char = N;code = 78
char = A;code = 65
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char = m;code = 109
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = a;code = 97
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char = o;code = 111
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char = o;code = 111
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char = e;code = 101
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char = -;code = 45
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char = v;code = 118
char = i;code = 105
char = v;code = 118
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char = n;code = 110
char = g;code = 103
char = ;code = 32
char = H;code = 72
char = C;code = 67
char = T;code = 84
char = -;code = 45
char = 1;code = 49
char = 1;code = 49
char = 6;code = 54
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = a;code = 97
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char = a;code = 97
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char = d;code = 100
char = i;code = 105
char = t;code = 116
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char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = F;code = 70
char = O;code = 79
char = L;code = 76
char = F;code = 70
char = O;code = 79
char = X;code = 88
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = c;code = 99
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result sql = Curcumin (diferuloylmethane), which has no discernible toxicity, inhibits initiation, promotion and progression of carcinogenesis. 5-Fluorouracil (5-FU) or 5-FU plus oxaliplatin (FOLFOX) remains the backbone of colorectal cancer chemotherapeutics, but produces an incomplete response resulting in survival of cells (chemo-surviving cells) that may lead to cancer recurrence. The present investigation was, therefore, undertaken to examine whether addition of curcumin to FOLFOX is a superior therapeutic strategy for chemo-surviving cells. Forty-eight-hour treatment of colon cancer HCT-116 and HT-29 cells with FOLFOX resulted in 60-70% survival, accompanied by a marked activation of insulin like growth factor-1 receptor (IGF-1R) and minor to moderate increase in epidermal growth factor receptor (EGFR), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (HER-2) as well as v-akt murine thymoma viral oncogene homolog 1 (AKT), cyclooxygenase-2 (COX-2) and cyclin-D1. However, inclusion of curcumin to continued FOLFOX treatment for another 48 h greatly reduced the survival of these cells, accompanied by a concomitant reduction in activation of EGFR, HER-2, IGF-1R and AKT, as well as expression of COX-2 and cyclin-D1. More importantly, EGFR tyrosine kinase inhibitor gefitinib or attenuation of IGF-1R expression by the corresponding si-RNA caused a 30-60% growth inhibition of chemo-surviving HCT-116 cells. However, curcumin alone was found to be more effective than both gefitinib and IGF-1R si-RNA mediated growth inhibition of chemo-surviving HCT-116 cells and addition of FOLFOX to curcumin did not increase the growth inhibitory effect of curcumin. Our data suggest that inclusion of curcumin in conventional chemotherapeutic regimens could be an effective strategy to prevent the emergence of chemoresistant colon cancer cells.
Publication: Anticancer Res. 2010 Feb ;30(2)::319-25.
Publication Date: 2010 Feb
Study Author(s): Patel, Bhaumik B;Gupta, Deepshika;Elliott, Althea A;Sengupta, Vivek;Yu, Yingjie;Majumdar, Adhip P N;
Institution: Department of Veterans Affairs Medical Center, Karmanos Cancer Center, Wayne State University, Detroit, MI 48201, USA.
Shortcut link to this study:
Publication Date: 2010 Feb
Study Author(s): Patel, Bhaumik B;Gupta, Deepshika;Elliott, Althea A;Sengupta, Vivek;Yu, Yingjie;Majumdar, Adhip P N;
Institution: Department of Veterans Affairs Medical Center, Karmanos Cancer Center, Wayne State University, Detroit, MI 48201, USA.
Shortcut link to this study:
Curcumin (diferuloylmethane), which has no discernible toxicity, inhibits initiation, promotion and progression of carcinogenesis. 5-Fluorouracil (5-FU) or 5-FU plus oxaliplatin (FOLFOX) remains the backbone of colorectal cancer chemotherapeutics, but produces an incomplete response resulting in survival of cells (chemo-surviving cells) that may lead to cancer recurrence. The present investigation was, therefore, undertaken to examine whether addition of curcumin to FOLFOX is a superior therapeutic strategy for chemo-surviving cells. Forty-eight-hour treatment of colon cancer HCT-116 and HT-29 cells with FOLFOX resulted in 60-70% survival, accompanied by a marked activation of insulin like growth factor-1 receptor (IGF-1R) and minor to moderate increase in epidermal growth factor receptor (EGFR), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (HER-2) as well as v-akt murine thymoma viral oncogene homolog 1 (AKT), cyclooxygenase-2 (COX-2) and cyclin-D1. However, inclusion of curcumin to continued FOLFOX treatment for another 48 h greatly reduced the survival of these cells, accompanied by a concomitant reduction in activation of EGFR, HER-2, IGF-1R and AKT, as well as expression of COX-2 and cyclin-D1. More importantly, EGFR tyrosine kinase inhibitor gefitinib or attenuation of IGF-1R expression by the corresponding si-RNA caused a 30-60% growth inhibition of chemo-surviving HCT-116 cells. However, curcumin alone was found to be more effective than both gefitinib and IGF-1R si-RNA mediated growth inhibition of chemo-surviving HCT-116 cells and addition of FOLFOX to curcumin did not increase the growth inhibitory effect of curcumin. Our data suggest that inclusion of curcumin in conventional chemotherapeutic regimens could be an effective strategy to prevent the emergence of chemoresistant colon cancer cells.
PMID: 20332435
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