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result sql = Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells.
Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells.char = P;code = 80
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result sql = Phytochemical compounds and histone deacetylase (HDAC) inhibitors are emerging as a new generation of anticancer agents with limited toxicity in cancer patients. We investigated the impact of luteolin, a dietary flavonoid, on survival, migration, invasion of cancer cells in vitro, and tumor growth in vivo. Luteolin (25-200μM) decreased the viability of human cancer cell lines originating from the lung (LNM35), colon (HT29), liver (HepG2) and breast (MCF7/6 and MDA-MB231-1833). Luteolin effectively increased the sub-G1 (apoptotic) fraction of cells through caspase-3 and -7 dependent pathways. We provide evidence that luteolin at sub-lethal/non-toxic concentrations inhibited the invasive potential of LNM35, MCF-7/6 and MDA-MB231-1833 cancer cells using Matrigel as well as the chick heart and Oris invasion assays. Moreover, we demonstrate for the first time that luteolin is a potent HDAC inhibitor that potentiates the cytotoxicity of cisplatin in LNM35 cells and decreases the growth of LNM35 tumor xenografts in athymic mice after intraperitoneal injection (20mg/kg/day for 18days) Thus, luteolin, in combination with standard anticancer drugs such as cisplatin, may be a promising HDAC inhibitor for the treatment of lung cancer.
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result sql = Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells.
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char = ;code = 32
char = c;code = 99
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char = c;code = 99
char = e;code = 101
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = i;code = 105
char = n;code = 110
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char = i;code = 105
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
char = r;code = 114
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char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = v;code = 118
char = o;code = 111
char = .;code = 46
char = ;code = 32
char = L;code = 76
char = u;code = 117
char = t;code = 116
char = e;code = 101
char = o;code = 111
char = l;code = 108
char = i;code = 105
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char = 2;code = 50
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char = 2;code = 50
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char = 0;code = 48
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char = #;code = 35
char = 9;code = 57
char = 5;code = 53
char = 6;code = 54
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char = ;code = 32
char = d;code = 100
char = e;code = 101
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char = r;code = 114
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char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = v;code = 118
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char = a;code = 97
char = b;code = 98
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = t;code = 116
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char = f;code = 102
char = ;code = 32
char = h;code = 104
char = u;code = 117
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char = a;code = 97
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char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = s;code = 115
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char = o;code = 111
char = r;code = 114
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char = g;code = 103
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = t;code = 116
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char = n;code = 110
char = g;code = 103
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = l;code = 108
char = u;code = 117
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = (;code = 40
char = L;code = 76
char = N;code = 78
char = M;code = 77
char = 3;code = 51
char = 5;code = 53
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = (;code = 40
char = H;code = 72
char = T;code = 84
char = 2;code = 50
char = 9;code = 57
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = r;code = 114
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char = (;code = 40
char = H;code = 72
char = e;code = 101
char = p;code = 112
char = G;code = 71
char = 2;code = 50
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char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = (;code = 40
char = M;code = 77
char = C;code = 67
char = F;code = 70
char = 7;code = 55
char = /;code = 47
char = 6;code = 54
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = M;code = 77
char = D;code = 68
char = A;code = 65
char = -;code = 45
char = M;code = 77
char = B;code = 66
char = 2;code = 50
char = 3;code = 51
char = 1;code = 49
char = -;code = 45
char = 1;code = 49
char = 8;code = 56
char = 3;code = 51
char = 3;code = 51
char = );code = 41
char = .;code = 46
char = ;code = 32
char = L;code = 76
char = u;code = 117
char = t;code = 116
char = e;code = 101
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = -;code = 45
char = G;code = 71
char = 1;code = 49
char = ;code = 32
char = (;code = 40
char = a;code = 97
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = );code = 41
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = g;code = 103
char = h;code = 104
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = s;code = 115
char = p;code = 112
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = 3;code = 51
char = ;code = 32
char = a;code = 97
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char = -;code = 45
char = 7;code = 55
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char = d;code = 100
char = e;code = 101
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char = e;code = 101
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char = d;code = 100
char = e;code = 101
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char = t;code = 116
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char = p;code = 112
char = a;code = 97
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char = h;code = 104
char = w;code = 119
char = a;code = 97
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char = s;code = 115
char = .;code = 46
char = ;code = 32
char = W;code = 87
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = v;code = 118
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char = d;code = 100
char = e;code = 101
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char = e;code = 101
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char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = c;code = 99
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char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = l;code = 108
char = u;code = 117
char = t;code = 116
char = e;code = 101
char = o;code = 111
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char = i;code = 105
char = n;code = 110
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char = a;code = 97
char = t;code = 116
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = b;code = 98
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char = l;code = 108
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = l;code = 108
char = /;code = 47
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char = o;code = 111
char = n;code = 110
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char = t;code = 116
char = o;code = 111
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char = i;code = 105
char = c;code = 99
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char = c;code = 99
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char = c;code = 99
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char = t;code = 116
char = r;code = 114
char = a;code = 97
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char = o;code = 111
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char = s;code = 115
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char = i;code = 105
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char = d;code = 100
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = n;code = 110
char = v;code = 118
char = a;code = 97
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char = e;code = 101
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char = p;code = 112
char = o;code = 111
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char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = L;code = 76
char = N;code = 78
char = M;code = 77
char = 3;code = 51
char = 5;code = 53
char = ,;code = 44
char = ;code = 32
char = M;code = 77
char = C;code = 67
char = F;code = 70
char = -;code = 45
char = 7;code = 55
char = /;code = 47
char = 6;code = 54
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = M;code = 77
char = D;code = 68
char = A;code = 65
char = -;code = 45
char = M;code = 77
char = B;code = 66
char = 2;code = 50
char = 3;code = 51
char = 1;code = 49
char = -;code = 45
char = 1;code = 49
char = 8;code = 56
char = 3;code = 51
char = 3;code = 51
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char = c;code = 99
char = a;code = 97
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char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = u;code = 117
char = s;code = 115
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char = n;code = 110
char = g;code = 103
char = ;code = 32
char = M;code = 77
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char = t;code = 116
char = r;code = 114
char = i;code = 105
char = g;code = 103
char = e;code = 101
char = l;code = 108
char = ;code = 32
char = a;code = 97
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char = w;code = 119
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char = l;code = 108
char = l;code = 108
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char = a;code = 97
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char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = c;code = 99
char = h;code = 104
char = i;code = 105
char = c;code = 99
char = k;code = 107
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char = e;code = 101
char = a;code = 97
char = r;code = 114
char = t;code = 116
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = O;code = 79
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = v;code = 118
char = a;code = 97
char = s;code = 115
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char = o;code = 111
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char = a;code = 97
char = s;code = 115
char = s;code = 115
char = a;code = 97
char = y;code = 121
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char = .;code = 46
char = ;code = 32
char = M;code = 77
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = o;code = 111
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char = e;code = 101
char = r;code = 114
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char = w;code = 119
char = e;code = 101
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char = d;code = 100
char = e;code = 101
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char = o;code = 111
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char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
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char = e;code = 101
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char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = f;code = 102
char = i;code = 105
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char = s;code = 115
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char = a;code = 97
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char = a;code = 97
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char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
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char = H;code = 72
char = D;code = 68
char = A;code = 65
char = C;code = 67
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char = i;code = 105
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char = L;code = 76
char = N;code = 78
char = M;code = 77
char = 3;code = 51
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char = c;code = 99
char = e;code = 101
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char = d;code = 100
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char = o;code = 111
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = L;code = 76
char = N;code = 78
char = M;code = 77
char = 3;code = 51
char = 5;code = 53
char = ;code = 32
char = t;code = 116
char = u;code = 117
char = m;code = 109
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char = a;code = 97
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char = t;code = 116
char = s;code = 115
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char = a;code = 97
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char = c;code = 99
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char = a;code = 97
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char = t;code = 116
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char = i;code = 105
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char = a;code = 97
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char = e;code = 101
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char = t;code = 116
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char = e;code = 101
char = a;code = 97
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char = c;code = 99
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char = 2;code = 50
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char = a;code = 97
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char = o;code = 111
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char = d;code = 100
char = a;code = 97
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char = s;code = 115
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char = ;code = 32
char = T;code = 84
char = h;code = 104
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char = b;code = 98
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char = a;code = 97
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char = t;code = 116
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char = g;code = 103
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char = s;code = 115
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char = h;code = 104
char = ;code = 32
char = a;code = 97
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result sql = Phytochemical compounds and histone deacetylase (HDAC) inhibitors are emerging as a new generation of anticancer agents with limited toxicity in cancer patients. We investigated the impact of luteolin, a dietary flavonoid, on survival, migration, invasion of cancer cells in vitro, and tumor growth in vivo. Luteolin (25-200μM) decreased the viability of human cancer cell lines originating from the lung (LNM35), colon (HT29), liver (HepG2) and breast (MCF7/6 and MDA-MB231-1833). Luteolin effectively increased the sub-G1 (apoptotic) fraction of cells through caspase-3 and -7 dependent pathways. We provide evidence that luteolin at sub-lethal/non-toxic concentrations inhibited the invasive potential of LNM35, MCF-7/6 and MDA-MB231-1833 cancer cells using Matrigel as well as the chick heart and Oris invasion assays. Moreover, we demonstrate for the first time that luteolin is a potent HDAC inhibitor that potentiates the cytotoxicity of cisplatin in LNM35 cells and decreases the growth of LNM35 tumor xenografts in athymic mice after intraperitoneal injection (20mg/kg/day for 18days) Thus, luteolin, in combination with standard anticancer drugs such as cisplatin, may be a promising HDAC inhibitor for the treatment of lung cancer.
Publication: Eur. J. Pharmacol. 2011 Jan 25 ;651(1-3)::18-25. :doi: 10.1016/j.ejphar.2010.10.063.
Publication Date: 2011 Jan 25
Study Author(s): Attoub, Samir;Hassan, Ahmed H;Vanhoecke, Barbara;Iratni, Rabah;Takahashi, Takashi;Gaben, Anne-Marie;Bracke, Marc;Awad, Salma;John, Anne;Kamalboor, Hamda Ahmed;Al Sultan, Mahmood Ahmed;Arafat, Kholoud;Gespach, Christian;Petroianu, Georg;
Institution: Department of Pharmacology & Therapeutics, United Arab Emirates University, Al-Ain, United Arab Emirates. [email protected]
Shortcut link to this study:
Publication Date: 2011 Jan 25
Study Author(s): Attoub, Samir;Hassan, Ahmed H;Vanhoecke, Barbara;Iratni, Rabah;Takahashi, Takashi;Gaben, Anne-Marie;Bracke, Marc;Awad, Salma;John, Anne;Kamalboor, Hamda Ahmed;Al Sultan, Mahmood Ahmed;Arafat, Kholoud;Gespach, Christian;Petroianu, Georg;
Institution: Department of Pharmacology & Therapeutics, United Arab Emirates University, Al-Ain, United Arab Emirates. [email protected]
Shortcut link to this study:
Phytochemical compounds and histone deacetylase (HDAC) inhibitors are emerging as a new generation of anticancer agents with limited toxicity in cancer patients. We investigated the impact of luteolin, a dietary flavonoid, on survival, migration, invasion of cancer cells in vitro, and tumor growth in vivo. Luteolin (25-200μM) decreased the viability of human cancer cell lines originating from the lung (LNM35), colon (HT29), liver (HepG2) and breast (MCF7/6 and MDA-MB231-1833). Luteolin effectively increased the sub-G1 (apoptotic) fraction of cells through caspase-3 and -7 dependent pathways. We provide evidence that luteolin at sub-lethal/non-toxic concentrations inhibited the invasive potential of LNM35, MCF-7/6 and MDA-MB231-1833 cancer cells using Matrigel as well as the chick heart and Oris invasion assays. Moreover, we demonstrate for the first time that luteolin is a potent HDAC inhibitor that potentiates the cytotoxicity of cisplatin in LNM35 cells and decreases the growth of LNM35 tumor xenografts in athymic mice after intraperitoneal injection (20mg/kg/day for 18days) Thus, luteolin, in combination with standard anticancer drugs such as cisplatin, may be a promising HDAC inhibitor for the treatment of lung cancer.
PMID: 21074525
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