char = R;code = 82
char = e;code = 101
char = d;code = 100
char = o;code = 111
char = x;code = 120
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char = m;code = 109
char = o;code = 111
char = d;code = 100
char = u;code = 117
char = l;code = 108
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char = t;code = 116
char = i;code = 105
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = b;code = 98
char = i;code = 105
char = l;code = 108
char = e;code = 101
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char = d;code = 100
char = u;code = 117
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char = t;code = 116
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = r;code = 114
char = c;code = 99
char = u;code = 117
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = .;code = 46
result sql = Redox modulation and human bile duct cancer inhibition by curcumin.
Redox modulation and human bile duct cancer inhibition by curcumin.
char = C;code = 67
char = u;code = 117
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char = c;code = 99
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char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = m;code = 109
char = a;code = 97
char = j;code = 106
char = o;code = 111
char = r;code = 114
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char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = o;code = 111
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char = n;code = 110
char = t;code = 116
char = ;code = 32
char = f;code = 102
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char = o;code = 111
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char = m;code = 109
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char = l;code = 108
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char = k;code = 107
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char = n;code = 110
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char = s;code = 115
char = s;code = 115
char = e;code = 101
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char = a;code = 97
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char = c;code = 99
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char = e;code = 101
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char = ;code = 32
char = T;code = 84
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char = t;code = 116
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char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = i;code = 105
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char = ;code = 32
char = s;code = 115
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char = g;code = 103
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char = e;code = 101
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char = o;code = 111
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char = a;code = 97
char = c;code = 99
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char = t;code = 116
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char = h;code = 104
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char = e;code = 101
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char = y;code = 121
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = t;code = 116
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char = d;code = 100
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char = w;code = 119
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char = ;code = 32
char = t;code = 116
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char = ;code = 32
char = c;code = 99
char = l;code = 108
char = a;code = 97
char = r;code = 114
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char = f;code = 102
char = y;code = 121
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char = f;code = 102
char = e;code = 101
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char = c;code = 99
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char = c;code = 99
char = a;code = 97
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char = c;code = 99
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = b;code = 98
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char = d;code = 100
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char = a;code = 97
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char = y;code = 121
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = c;code = 99
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char = e;code = 101
char = m;code = 109
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char = h;code = 104
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char = a;code = 97
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char = e;code = 101
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char = c;code = 99
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char = W;code = 87
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char = e;code = 101
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char = a;code = 97
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char = f;code = 102
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char = a;code = 97
char = n;code = 110
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char = i;code = 105
char = t;code = 116
char = u;code = 117
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char = a;code = 97
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char = ;code = 32
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char = K;code = 75
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char = C;code = 67
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result sql = Curcumin, a major component from tumeric and well-known dietary spice, possesses various pharmacological effects. The cancer chemoprevention effect is suggested to act through its pro-oxidant property. The study was to clarify effects of curcumin on cholangiocarcinoma cells, a cancer of the bile duct that refractory to chemotherapeutic drugs. We examined time-course of oxidant formation in relation to antitumor and the adaptive antioxidant response of the cells. Curcumin induced antiproliferation and apoptosis in KKU-M214 CCA cells with concentration- and time- dependent manners. The antiproliferative effect of curcumin was observed at concentrations as low as 3 microM and was not necessarily associated with oxidative stress, while induction of apoptosis required significant production of superoxide anion, suppression of cellular redox and collapse of mitochondrial transmembrane potential. Western blot analysis showed a temporal relationship between the suppression of nuclear NF-kappaB with Bcl-XL protein levels. Up-regulation of p53 and Bax was associated with marked oxidative stress and apoptosis. Curcumin also induced Nrf2 protein expression with up-regulation of gamma-glutamylcysteine ligase mRNA and increased cellular antioxidant, glutathione. The study suggests that curcumin could be developed into an effective chemoprevention against CCA.

Publication: Food Chem. Toxicol. 2010 Aug-Sep ;48(8-9)::2265-72. :doi: 10.1016/j.fct.2010.05.059.
Publication Date: 2010 Aug-Sep
Study Author(s): Suphim, Bunliang;Prawan, Auemduan;Kukongviriyapan, Upa;Kongpetch, Sarinya;Buranrat, Benjaporn;Kukongviriyapan, Veerapol;
Institution: Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Shortcut link to this study:
Curcumin, a major component from tumeric and well-known dietary spice, possesses various pharmacological effects. The cancer chemoprevention effect is suggested to act through its pro-oxidant property. The study was to clarify effects of curcumin on cholangiocarcinoma cells, a cancer of the bile duct that refractory to chemotherapeutic drugs. We examined time-course of oxidant formation in relation to antitumor and the adaptive antioxidant response of the cells. Curcumin induced antiproliferation and apoptosis in KKU-M214 CCA cells with concentration- and time- dependent manners. The antiproliferative effect of curcumin was observed at concentrations as low as 3 microM and was not necessarily associated with oxidative stress, while induction of apoptosis required significant production of superoxide anion, suppression of cellular redox and collapse of mitochondrial transmembrane potential. Western blot analysis showed a temporal relationship between the suppression of nuclear NF-kappaB with Bcl-XL protein levels. Up-regulation of p53 and Bax was associated with marked oxidative stress and apoptosis. Curcumin also induced Nrf2 protein expression with up-regulation of gamma-glutamylcysteine ligase mRNA and increased cellular antioxidant, glutathione. The study suggests that curcumin could be developed into an effective chemoprevention against CCA.
PMID: 20510329

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