char = C;code = 67
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = i;code = 105
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = n;code = 110
char = e;code = 101
char = l;code = 108
char = ;code = 32
char = b;code = 98
char = l;code = 108
char = o;code = 111
char = c;code = 99
char = k;code = 107
char = e;code = 101
char = r;code = 114
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char = u;code = 117
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = r;code = 114
char = i;code = 105
char = s;code = 115
char = k;code = 107
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
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char = o;code = 111
char = s;code = 115
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char = t;code = 116
char = e;code = 101
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char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = .;code = 46
result sql = Calcium channel blocker use and the risk of prostate cancer.
Calcium channel blocker use and the risk of prostate cancer.
char = A;code = 65
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
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char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = g;code = 103
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = k;code = 107
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
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char = u;code = 117
char = d;code = 100
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char = g;code = 103
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = ,;code = 44
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
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char = e;code = 101
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = u;code = 117
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = i;code = 105
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = n;code = 110
char = e;code = 101
char = l;code = 108
char = ;code = 32
char = b;code = 98
char = l;code = 108
char = o;code = 111
char = c;code = 99
char = k;code = 107
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = b;code = 98
char = j;code = 106
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = t;code = 116
char = e;code = 101
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char = m;code = 109
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = p;code = 112
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
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char = i;code = 105
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = c;code = 99
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char = u;code = 117
char = m;code = 109
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char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = n;code = 110
char = e;code = 101
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char = ;code = 32
char = b;code = 98
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char = u;code = 117
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char = e;code = 101
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char = ;code = 32
char = A;code = 65
char = ;code = 32
char = c;code = 99
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char = e;code = 101
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char = c;code = 99
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char = t;code = 116
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = s;code = 115
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char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ;code = 32
char = w;code = 119
char = a;code = 97
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char = ;code = 32
char = c;code = 99
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char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = M;code = 77
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = a;code = 97
char = c;code = 99
char = h;code = 104
char = u;code = 117
char = s;code = 115
char = e;code = 101
char = t;code = 116
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = u;code = 117
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = e;code = 101
char = s;code = 115
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = a;code = 97
char = g;code = 103
char = n;code = 110
char = o;code = 111
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = D;code = 68
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = m;code = 109
char = b;code = 98
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = 1;code = 49
char = 9;code = 57
char = 9;code = 57
char = 2;code = 50
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = g;code = 103
char = h;code = 104
char = ;code = 32
char = F;code = 70
char = e;code = 101
char = b;code = 98
char = r;code = 114
char = u;code = 117
char = a;code = 97
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = 1;code = 49
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char = 9;code = 57
char = 5;code = 53
char = .;code = 46
char = ;code = 32
char = C;code = 67
char = a;code = 97
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char = e;code = 101
char = s;code = 115
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = n;code = 110
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char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = g;code = 103
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = r;code = 114
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = o;code = 111
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = n;code = 110
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char = 7;code = 55
char = 0;code = 48
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char = y;code = 121
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char = a;code = 97
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char = s;code = 115
char = ;code = 32
char = o;code = 111
char = l;code = 108
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = n;code = 110
char = e;code = 101
char = w;code = 119
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = a;code = 97
char = g;code = 103
char = n;code = 110
char = o;code = 111
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
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char = .;code = 46
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char = C;code = 67
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char = r;code = 114
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char = l;code = 108
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = a;code = 97
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char = m;code = 109
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char = a;code = 97
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char = 1;code = 49
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char = 0;code = 48
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char = c;code = 99
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char = m;code = 109
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char = s;code = 115
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char = r;code = 114
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char = l;code = 108
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char = u;code = 117
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char = n;code = 110
char = e;code = 101
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char = b;code = 98
char = l;code = 108
char = o;code = 111
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char = k;code = 107
char = e;code = 101
char = r;code = 114
char = s;code = 115
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char = u;code = 117
char = s;code = 115
char = e;code = 101
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char = w;code = 119
char = h;code = 104
char = i;code = 105
char = l;code = 108
char = e;code = 101
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char = c;code = 99
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char = n;code = 110
char = t;code = 116
char = r;code = 114
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char = l;code = 108
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = c;code = 99
char = o;code = 111
char = n;code = 110
char = f;code = 102
char = o;code = 111
char = u;code = 117
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char = d;code = 100
char = i;code = 105
char = n;code = 110
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = r;code = 114
char = e;code = 101
char = l;code = 108
char = a;code = 97
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char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = r;code = 114
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char = s;code = 115
char = k;code = 107
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char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = p;code = 112
char = r;code = 114
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char = s;code = 115
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char = t;code = 116
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char = c;code = 99
char = a;code = 97
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char = r;code = 114
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = c;code = 99
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char = u;code = 117
char = m;code = 109
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char = c;code = 99
char = h;code = 104
char = a;code = 97
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char = n;code = 110
char = e;code = 101
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char = b;code = 98
char = l;code = 108
char = o;code = 111
char = c;code = 99
char = k;code = 107
char = e;code = 101
char = r;code = 114
char = s;code = 115
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char = r;code = 114
char = e;code = 101
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = t;code = 116
char = o;code = 111
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char = n;code = 110
char = o;code = 111
char = n;code = 110
char = u;code = 117
char = s;code = 115
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char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = 1;code = 49
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char = 2;code = 50
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char = (;code = 40
char = 9;code = 57
char = 5;code = 53
char = %;code = 37
char = ;code = 32
char = c;code = 99
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char = f;code = 102
char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = c;code = 99
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = r;code = 114
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char = a;code = 97
char = l;code = 108
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char = [;code = 91
char = C;code = 67
char = I;code = 73
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char = ,;code = 44
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 9;code = 57
char = -;code = 45
char = 1;code = 49
char = .;code = 46
char = 5;code = 53
char = );code = 41
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = n;code = 110
char = o;code = 111
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char = e;code = 101
char = v;code = 118
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = c;code = 99
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char = d;code = 100
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = d;code = 100
char = u;code = 117
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = u;code = 117
char = s;code = 115
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = W;code = 87
char = h;code = 104
char = e;code = 101
char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = a;code = 97
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char = a;code = 97
char = l;code = 108
char = y;code = 121
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char = i;code = 105
char = s;code = 115
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char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = c;code = 99
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char = i;code = 105
char = n;code = 110
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = s;code = 115
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char = m;code = 109
char = p;code = 112
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char = o;code = 111
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char = a;code = 97
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char = i;code = 105
char = c;code = 99
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char = n;code = 110
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char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = e;code = 101
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = r;code = 114
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char = s;code = 115
char = k;code = 107
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char = e;code = 101
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = 1;code = 49
char = .;code = 46
char = 1;code = 49
char = ;code = 32
char = (;code = 40
char = 0;code = 48
char = .;code = 46
char = 8;code = 56
char = -;code = 45
char = 1;code = 49
char = .;code = 46
char = 4;code = 52
char = );code = 41
char = ;code = 32
char = o;code = 111
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = a;code = 97
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char = ;code = 32
char = 1;code = 49
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char = 2;code = 50
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char = (;code = 40
char = 0;code = 48
char = .;code = 46
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char = -;code = 45
char = 1;code = 49
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char = 7;code = 55
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char = a;code = 97
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char = o;code = 111
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char = t;code = 116
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char = a;code = 97
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char = e;code = 101
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char = t;code = 116
char = o;code = 111
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char = y;code = 121
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = s;code = 115
char = .;code = 46
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char = R;code = 82
char = e;code = 101
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = r;code = 114
char = i;code = 105
char = s;code = 115
char = k;code = 107
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char = m;code = 109
char = a;code = 97
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char = s;code = 115
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char = o;code = 111
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char = e;code = 101
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char = a;code = 97
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char = s;code = 115
char = e;code = 101
char = s;code = 115
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char = f;code = 102
char = ;code = 32
char = a;code = 97
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char = t;code = 116
char = i;code = 105
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char = y;code = 121
char = p;code = 112
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char = e;code = 101
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char = s;code = 115
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char = e;code = 101
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char = g;code = 103
char = s;code = 115
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char = s;code = 115
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char = m;code = 109
char = p;code = 112
char = t;code = 116
char = o;code = 111
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char = a;code = 97
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char = i;code = 105
char = c;code = 99
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char = c;code = 99
char = l;code = 108
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char = s;code = 115
char = e;code = 101
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char = t;code = 116
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char = 1;code = 49
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char = e;code = 101
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char = p;code = 112
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char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = m;code = 109
char = a;code = 97
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char = e;code = 101
char = s;code = 115
char = ;code = 32
char = a;code = 97
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char = o;code = 111
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char = g;code = 103
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char = a;code = 97
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char = t;code = 116
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char = i;code = 105
char = c;code = 99
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char = e;code = 101
char = r;code = 114
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char = g;code = 103
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char = r;code = 114
char = a;code = 97
char = l;code = 108
char = l;code = 108
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char = u;code = 117
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char = t;code = 116
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char = e;code = 101
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char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = 1;code = 49
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char = .;code = 46
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char = T;code = 84
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = f;code = 102
char = i;code = 105
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char = c;code = 99
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char = T;code = 84
char = h;code = 104
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char = d;code = 100
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char = v;code = 118
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char = s;code = 115
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char = m;code = 109
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char = p;code = 112
char = a;code = 97
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char = i;code = 105
char = b;code = 98
char = l;code = 108
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char = o;code = 111
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char = b;code = 98
char = i;code = 105
char = a;code = 97
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char = e;code = 101
char = c;code = 99
char = a;code = 97
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char = s;code = 115
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char = f;code = 102
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char = i;code = 105
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char = a;code = 97
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char = u;code = 117
char = s;code = 115
char = e;code = 101
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char = f;code = 102
char = ;code = 32
char = P;code = 80
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char = s;code = 115
char = t;code = 116
char = a;code = 97
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char = e;code = 101
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char = S;code = 83
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char = e;code = 101
char = c;code = 99
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char = f;code = 102
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char = c;code = 99
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char = n;code = 110
char = t;code = 116
char = i;code = 105
char = g;code = 103
char = e;code = 101
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result sql = A recent study suggested that the risk of all cancers, including prostate cancer, is increased by the use of calcium channel blockers. The objective of this study was to determine whether prostate cancer is associated with calcium channel blocker use. A case-control study was conducted in Massachusetts using cases diagnosed from December 1992 through February 1995. Cases were men identified by tumor registrars who were less than 70 years old with newly diagnosed prostate cancer. Controls were men with no history of prostate cancer or symptoms of undiagnosed prostate cancer, and were matched to the cases on precinct of residence and half-decade of age. A total of 1217 cases of prostate cancer and 1400 community controls are included in this analysis. Data were collected by telephone interview. Multiple logistic regression was used to estimate relative risks for calcium channel blockers use while controlling for confounding. The relative risk for prostate cancer for any use of calcium channel blockers relative to nonuse was 1.2 (95% confidence interval [CI], 0.9-1.5). There was no evidence of a trend according to duration of use. When the analysis was confined to symptomatic men, the relative risk estimate was 1.1 (0.8-1.4) overall and 1.2 (0.8-1.7) among those aged 65 to 69 years. Relative risk estimates for the use of other classes of antihypertensive drugs among symptomatic men were close to 1.0; the corresponding estimates among asymptomatic men were generally further from 1.0. These findings suggest that calcium channel blockers do not increase the risk of prostate cancer. The differences in the relative risk estimates between symptomatic and asymptomatic men are compatible with detection bias. Because of the widespread use of Prostate-Specific Antigen testing for early detection of prostate cancer, potential detection bias needs to be considered in future studies of prostate cancer.

Publication: Am. J. Hypertens. 1998 Dec ;11(12)::1420-5.
Publication Date: 1998 Dec
Study Author(s): Vezina, R M;Lesko, S M;Rosenberg, L;Shapiro, S;
Institution: Slone Epidemiology Unit, Boston University School of Public Health, Massachusetts, USA. [email protected]
Shortcut link to this study:
A recent study suggested that the risk of all cancers, including prostate cancer, is increased by the use of calcium channel blockers. The objective of this study was to determine whether prostate cancer is associated with calcium channel blocker use. A case-control study was conducted in Massachusetts using cases diagnosed from December 1992 through February 1995. Cases were men identified by tumor registrars who were less than 70 years old with newly diagnosed prostate cancer. Controls were men with no history of prostate cancer or symptoms of undiagnosed prostate cancer, and were matched to the cases on precinct of residence and half-decade of age. A total of 1217 cases of prostate cancer and 1400 community controls are included in this analysis. Data were collected by telephone interview. Multiple logistic regression was used to estimate relative risks for calcium channel blockers use while controlling for confounding. The relative risk for prostate cancer for any use of calcium channel blockers relative to nonuse was 1.2 (95% confidence interval [CI], 0.9-1.5). There was no evidence of a trend according to duration of use. When the analysis was confined to symptomatic men, the relative risk estimate was 1.1 (0.8-1.4) overall and 1.2 (0.8-1.7) among those aged 65 to 69 years. Relative risk estimates for the use of other classes of antihypertensive drugs among symptomatic men were close to 1.0; the corresponding estimates among asymptomatic men were generally further from 1.0. These findings suggest that calcium channel blockers do not increase the risk of prostate cancer. The differences in the relative risk estimates between symptomatic and asymptomatic men are compatible with detection bias. Because of the widespread use of Prostate-Specific Antigen testing for early detection of prostate cancer, potential detection bias needs to be considered in future studies of prostate cancer.
PMID: 9880123

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