Pharmacological Actions

Alphabetical:

12-lipoxygenase   (882 occurrences)
5-alpha reductase inhibitor   (7123 occurrences)
5-HTergic   (122 occurrences)
5-Lipoxygenase Inhibitor   (4013 occurrences)
Abortifacient   (600 occurrences)
Acetylcholinesterase Inhibitor   (3012 occurrences)
Adenosine deaminase inhibitor   (5493 occurrences)
Adiponectin upregulation   (168 occurrences)
Adjuvants   (5537 occurrences)
Adrenergic   (8949 occurrences)
Adrenergic Agonists   (5420 occurrences)
Air Pollutants   (5288 occurrences)
Aldose reductase inhibitor   (3001 occurrences)
Alpha-amylase inhibitor   (641 occurrences)
Alpha-glucosidase inhibitor   (720 occurrences)
Anabolic   (5965 occurrences)
Analgesics   (5950 occurrences)
Androgen Antagonists   (844 occurrences)
Androgens   (6348 occurrences)
Anesthetics   (6257 occurrences)
Angiogenesis Inhibitors   (5126 occurrences)
Angiotensin II Type 1 Receptor Blockers   (23 occurrences)
Angiotensin-Converting Enzyme Inhibitors   (9098 occurrences)
Antacids   (2107 occurrences)
Anti-Adipogenic   (310 occurrences)
Anti-Allergic   (3132 occurrences)
Anti-Androgen   (3214 occurrences)
Anti-Angiogenic   (6320 occurrences)
Anti-Anxiety   (1230 occurrences)
Anti-Apoptotic   (6553 occurrences)
Anti-Arrhythmia   (476 occurrences)
Anti-Asthmatic   (1299 occurrences)
Anti-atherogenic   (3791 occurrences)
Anti-Bacterial   (8668 occurrences)
Anticarcinogenic   (2230 occurrences)
Anticholinergic   (5281 occurrences)
Anticoagulants   (5869 occurrences)
Anticonvulsants   (5173 occurrences)
Antidepressive   (1866 occurrences)
Antidiarrheals   (80 occurrences)
Anti-elastase   (287 occurrences)
Antiemetics   (1660 occurrences)
Anti-Estrogenic   (2059 occurrences)
Anti-Fibrotic   (2970 occurrences)
Antifungal   (8285 occurrences)
Anti-HIV   (6232 occurrences)
Antihypertensive   (8550 occurrences)
Anti-Infective   (1981 occurrences)
Anti-Inflammatory   (9068 occurrences)
Antimalarials   (2274 occurrences)
Anti-metastatic   (2742 occurrences)
Antimicrobial   (9112 occurrences)
Antimitotic   (1850 occurrences)
Antimutagenic   (1609 occurrences)
Antimycobacterial   (2313 occurrences)
Antineoplastic   (6305 occurrences)
Antioxidants   (8218 occurrences)
Antiparasitic   (2335 occurrences)
Anti-Platelet   (6713 occurrences)
Antiproliferative   (7142 occurrences)
Anti-Proliferative   (7879 occurrences)
Antiprotozoal   (836 occurrences)
Anti-Psychotic   (7533 occurrences)
Anti-pyretic   (2669 occurrences)
Anti-Retroviral   (8723 occurrences)
Antispasmodic   (799 occurrences)
Anti-thrombotic   (6177 occurrences)
Antitubercular   (1724 occurrences)
Anti-Tumor   (9143 occurrences)
Antitussive   (937 occurrences)
Anti-Ulcer   (2666 occurrences)
Antiurolithiatic   (21 occurrences)
Antiviral   (8685 occurrences)
Anxiolytic   (5577 occurrences)
Aphrodisiac   (335 occurrences)
Apoptotic   (9203 occurrences)
Aromatase Inhibitors   (3208 occurrences)
Autophagy Up-regulation   (2268 occurrences)
Bcl-2 protein down-regulation   (5834 occurrences)
Bcl-xL down-regulation   (861 occurrences)
Benzodiazepine receptor agonist   (5627 occurrences)
Bronchoconstrictor   (1224 occurrences)
Bronchodilator   (5321 occurrences)
Calcium Channel Blockers   (8351 occurrences)
Cannabinoid Receptor Antagonist   (5546 occurrences)
Carcinogens   (6116 occurrences)
Cardioprotective   (5872 occurrences)
Cardiotonic   (1378 occurrences)
Cardiovascular   (9499 occurrences)
Carminative   (84 occurrences)
Caspase-2 Activation   (6325 occurrences)
Caspase-3 Activation   (6325 occurrences)
Caspase-3 Inhibition   (5240 occurrences)
Caspase-8 activation   (6325 occurrences)
Caspase-9 Activation   (6325 occurrences)
Cell cycle arrest   (9045 occurrences)
Chelating   (6053 occurrences)
Chemopreventive   (5717 occurrences)
Chemosensitizer   (263 occurrences)
Chemotherapeutic   (7479 occurrences)
Cholinergic   (8664 occurrences)
Cholinergic Antagonists   (3263 occurrences)
Cholinesterase Inhibitors   (2549 occurrences)
Chondroprotective   (514 occurrences)
Chymotrypsin Inhibitor   (2995 occurrences)
Cicatrizing   (138 occurrences)
Contraceptive   (8115 occurrences)
Cyclin-Dependent Kinase Inhibitor   (6584 occurrences)
Cyclooxygenase 2 Inhibitors   (27 occurrences)
Cyclooxygenase Inhibitors   (5456 occurrences)
Cytoprotective   (5518 occurrences)
Cytotoxic   (9498 occurrences)
Cytotoxins   (1241 occurrences)
Dermatologic   (5629 occurrences)
Detoxifier   (47 occurrences)
Disinfectants   (2983 occurrences)
Diuretics   (5563 occurrences)
Dopamine   (8997 occurrences)
Dopamine Agonists   (5537 occurrences)
Dopaminergic   (8728 occurrences)
Drug synergy   (1662 occurrences)
E-cadherin down-regulation   (1649 occurrences)
Enkephalinase inhibitor   (312 occurrences)
Enzyme Inhibitors   (7519 occurrences)
Epidermal growth factor receptor inhibitor   (9363 occurrences)
Ergogenic   (845 occurrences)
Eryptotic   (35 occurrences)
Erythropoietic   (3473 occurrences)
Estrogen Antagonists   (1383 occurrences)
Estrogen Receptor Agonist   (9076 occurrences)
Estrogen Receptor Modulators   (9075 occurrences)
Expectorants   (123 occurrences)
Fatty Acid Oxidation   (9160 occurrences)
Fibrinolytic   (6338 occurrences)
GABA Modulators   (889 occurrences)
Galactogogue   (18 occurrences)
Gastroprotective   (1466 occurrences)
Genoprotective   (78 occurrences)
Glutathione S-transferase Inhibitor   (8478 occurrences)
Glycine   (7896 occurrences)
Glycogen synthase kinase-3beta Inhibitor   (5744 occurrences)
Heat Shock Protein Inducer   (8705 occurrences)
Hematologic   (7900 occurrences)
Hematopoietic   (9088 occurrences)
Hepatoprotective   (3280 occurrences)
Histamine H2 Antagonists   (5549 occurrences)
Histone deacetylase inhibitor   (7070 occurrences)
HIV Fusion Inhibitors   (6615 occurrences)
HIV Protease Inhibitors   (7093 occurrences)
HIV-1 Integrase Inhibitor   (6111 occurrences)
HMG-CoA reductase inhibitor   (5448 occurrences)
Hypnotics and Sedatives   (379 occurrences)
Hypoglycemic   (5660 occurrences)
Hypolipidemic   (3019 occurrences)
Hypomethylating   (479 occurrences)
Hypotensive   (6216 occurrences)
Immunomodulatory   (7143 occurrences)
Immunostimulatory   (4191 occurrences)
Immunosuppressive   (8686 occurrences)
Insulin Sensitizers   (589 occurrences)
Insulin-mimetic   (439 occurrences)
Insulinotrophic   (57 occurrences)
Insulin-releasing   (461 occurrences)
Interferon Inducers   (1008 occurrences)
Interleukin-1 receptor antagonist   (8625 occurrences)
Intracellular adhesion molecule-1   (5164 occurrences)
Iron Chelating   (2251 occurrences)
Laxative   (1685 occurrences)
Leishmanicidal   (641 occurrences)
Leukotriene Antagonists   (1539 occurrences)
Lipolytic   (5244 occurrences)
Lipotropic   (152 occurrences)
Lipoxygenase Inhibitors   (3212 occurrences)
Matrix metalloproteinase-2 inhibitor   (8883 occurrences)
Metal Chelation   (1739 occurrences)
Mitogen-activated protein kinase inhibitors   (9308 occurrences)
Mitogen-activated protein kinase kinase 4   (20 occurrences)
Molecular Probes   (5365 occurrences)
Monoamine Oxidase Inhibitors   (6758 occurrences)
Monoaminergic   (3845 occurrences)
Mucolytic   (766 occurrences)
Muscarinic Agonists   (3844 occurrences)
Muscarinic Antagonists   (3816 occurrences)
Muscle Relaxants   (2574 occurrences)
NADPH Oxidase Inhibitors   (5804 occurrences)
Natriuretic   (8297 occurrences)
Neuritogenic   (442 occurrences)
Neurogenesis   (6257 occurrences)
Neuroprotective   (8576 occurrences)
Neurorestorative   (212 occurrences)
Neutrophil Activation   (5607 occurrences)
NF-kappaB Inhibitor   (5103 occurrences)
Nitric Oxide Inhibitor   (9429 occurrences)
Noradrenergic   (6622 occurrences)
NOX2 inhibitor   (201 occurrences)
Osteogenic   (6500 occurrences)
Oxidants   (5500 occurrences)
Oxytocics   (161 occurrences)
P21 Activation   (4982 occurrences)
P-glycoprotein Inhibitors   (5192 occurrences)
Phosphodiesterase Inhibitors   (5315 occurrences)
Phospholipase D Inhibitors   (2 occurrences)
Photoprotective   (1154 occurrences)
Photosensitizing   (1736 occurrences)
Platelet aggregation inhibitor   (7751 occurrences)
PPAR-Gamma Up-Regulation   (1703 occurrences)
Progestagenic   (122 occurrences)
Protease Inhibitors   (6969 occurrences)
Proteasome Inhibitors   (4147 occurrences)
Protein Kinase C Inhibitor   (143 occurrences)
Protein Kinase Inhibitors   (9360 occurrences)
Proton Pump Inhibitor   (6171 occurrences)
Psychedelic   (206 occurrences)
Radiation-Sensitizing   (112 occurrences)
Radiopharmaceuticals   (3515 occurrences)
Radioprotective   (2214 occurrences)
Radiosensitizer   (1225 occurrences)
Regenerative   (6729 occurrences)
Renoprotective   (1952 occurrences)
Reverse Transcriptase Inhibitors   (8692 occurrences)
Ribonucleotide Reductase Inhibitor   (3248 occurrences)
Scolicidal   (124 occurrences)
Secretagogue   (4409 occurrences)
Selective Estrogen Receptor Modulators   (9318 occurrences)
Serine Proteinase Inhibitors   (5449 occurrences)
Serotonergic   (7573 occurrences)
Serotonin Agonists   (3918 occurrences)
SIRT1 Activator   (258 occurrences)
Spasmogenic   (492 occurrences)
Spermatogenic   (4442 occurrences)
STAT3 Inhibitor   (1828 occurrences)
Steroidogenesis   (6061 occurrences)
Stomachic   (63 occurrences)
Sulfonation   (603 occurrences)
Superoxide Scavenger   (3199 occurrences)
Survivin Down-Regulation   (804 occurrences)
Telomerase Inhibitor   (678 occurrences)
Telomerase Upregulation   (234 occurrences)
Teratogens   (1073 occurrences)
Thermogenic   (2483 occurrences)
Thrombolytic   (6337 occurrences)
Tocolytic   (1377 occurrences)
Topoisomerase I inhibitor   (83 occurrences)
Topoisomerase II Inhibitor   (5625 occurrences)
Transforming growth factor beta inhibitor   (9397 occurrences)
Trypanocidal   (1224 occurrences)
Tumor Necrosis Factor Alpha Inhibitor   (9508 occurrences)
Tyrosinase inhibitors   (526 occurrences)
Uncoupling   (6664 occurrences)
Uterotonic   (606 occurrences)
Vascular Endothelial Growth Factor Inhibitors   (9224 occurrences)
Vasodilator   (6470 occurrences)
Vasoprotective   (492 occurrences)
Xanthine oxidase inhibitor   (5458 occurrences)

By Popularity:

Tumor Necrosis Factor Alpha Inhibitor   (9508 occurrences)
Cardiovascular   (9499 occurrences)
Cytotoxic   (9498 occurrences)
Nitric Oxide Inhibitor   (9429 occurrences)
Transforming growth factor beta inhibitor   (9397 occurrences)
Epidermal growth factor receptor inhibitor   (9363 occurrences)
Protein Kinase Inhibitors   (9360 occurrences)
Selective Estrogen Receptor Modulators   (9318 occurrences)
Mitogen-activated protein kinase inhibitors   (9308 occurrences)
Vascular Endothelial Growth Factor Inhibitors   (9224 occurrences)
Apoptotic   (9203 occurrences)
Fatty Acid Oxidation   (9160 occurrences)
Anti-Tumor   (9143 occurrences)
Antimicrobial   (9112 occurrences)
Angiotensin-Converting Enzyme Inhibitors   (9098 occurrences)
Hematopoietic   (9088 occurrences)
Estrogen Receptor Agonist   (9076 occurrences)
Estrogen Receptor Modulators   (9075 occurrences)
Anti-Inflammatory   (9068 occurrences)
Cell cycle arrest   (9045 occurrences)
Dopamine   (8997 occurrences)
Adrenergic   (8949 occurrences)
Matrix metalloproteinase-2 inhibitor   (8883 occurrences)
Dopaminergic   (8728 occurrences)
Anti-Retroviral   (8723 occurrences)
Heat Shock Protein Inducer   (8705 occurrences)
Reverse Transcriptase Inhibitors   (8692 occurrences)
Immunosuppressive   (8686 occurrences)
Antiviral   (8685 occurrences)
Anti-Bacterial   (8668 occurrences)
Cholinergic   (8664 occurrences)
Interleukin-1 receptor antagonist   (8625 occurrences)
Neuroprotective   (8576 occurrences)
Antihypertensive   (8550 occurrences)
Glutathione S-transferase Inhibitor   (8478 occurrences)
Calcium Channel Blockers   (8351 occurrences)
Natriuretic   (8297 occurrences)
Antifungal   (8285 occurrences)
Antioxidants   (8218 occurrences)
Contraceptive   (8115 occurrences)
Hematologic   (7900 occurrences)
Glycine   (7896 occurrences)
Anti-Proliferative   (7879 occurrences)
Platelet aggregation inhibitor   (7751 occurrences)
Serotonergic   (7573 occurrences)
Anti-Psychotic   (7533 occurrences)
Enzyme Inhibitors   (7519 occurrences)
Chemotherapeutic   (7479 occurrences)
Immunomodulatory   (7143 occurrences)
Antiproliferative   (7142 occurrences)
5-alpha reductase inhibitor   (7123 occurrences)
HIV Protease Inhibitors   (7093 occurrences)
Histone deacetylase inhibitor   (7070 occurrences)
Protease Inhibitors   (6969 occurrences)
Monoamine Oxidase Inhibitors   (6758 occurrences)
Regenerative   (6729 occurrences)
Anti-Platelet   (6713 occurrences)
Uncoupling   (6664 occurrences)
Noradrenergic   (6622 occurrences)
HIV Fusion Inhibitors   (6615 occurrences)
Cyclin-Dependent Kinase Inhibitor   (6584 occurrences)
Anti-Apoptotic   (6553 occurrences)
Osteogenic   (6500 occurrences)
Vasodilator   (6470 occurrences)
Androgens   (6348 occurrences)
Fibrinolytic   (6338 occurrences)
Thrombolytic   (6337 occurrences)
Caspase-8 activation   (6325 occurrences)
Caspase-9 Activation   (6325 occurrences)
Caspase-2 Activation   (6325 occurrences)
Caspase-3 Activation   (6325 occurrences)
Anti-Angiogenic   (6320 occurrences)
Antineoplastic   (6305 occurrences)
Anesthetics   (6257 occurrences)
Neurogenesis   (6257 occurrences)
Anti-HIV   (6232 occurrences)
Hypotensive   (6216 occurrences)
Anti-thrombotic   (6177 occurrences)
Proton Pump Inhibitor   (6171 occurrences)
Carcinogens   (6116 occurrences)
HIV-1 Integrase Inhibitor   (6111 occurrences)
Steroidogenesis   (6061 occurrences)
Chelating   (6053 occurrences)
Anabolic   (5965 occurrences)
Analgesics   (5950 occurrences)
Cardioprotective   (5872 occurrences)
Anticoagulants   (5869 occurrences)
Bcl-2 protein down-regulation   (5834 occurrences)
NADPH Oxidase Inhibitors   (5804 occurrences)
Glycogen synthase kinase-3beta Inhibitor   (5744 occurrences)
Chemopreventive   (5717 occurrences)
Hypoglycemic   (5660 occurrences)
Dermatologic   (5629 occurrences)
Benzodiazepine receptor agonist   (5627 occurrences)
Topoisomerase II Inhibitor   (5625 occurrences)
Neutrophil Activation   (5607 occurrences)
Anxiolytic   (5577 occurrences)
Diuretics   (5563 occurrences)
Histamine H2 Antagonists   (5549 occurrences)
Cannabinoid Receptor Antagonist   (5546 occurrences)
Dopamine Agonists   (5537 occurrences)
Adjuvants   (5537 occurrences)
Cytoprotective   (5518 occurrences)
Oxidants   (5500 occurrences)
Adenosine deaminase inhibitor   (5493 occurrences)
Xanthine oxidase inhibitor   (5458 occurrences)
Cyclooxygenase Inhibitors   (5456 occurrences)
Serine Proteinase Inhibitors   (5449 occurrences)
HMG-CoA reductase inhibitor   (5448 occurrences)
Adrenergic Agonists   (5420 occurrences)
Molecular Probes   (5365 occurrences)
Bronchodilator   (5321 occurrences)
Phosphodiesterase Inhibitors   (5315 occurrences)
Air Pollutants   (5288 occurrences)
Anticholinergic   (5281 occurrences)
Lipolytic   (5244 occurrences)
Caspase-3 Inhibition   (5240 occurrences)
P-glycoprotein Inhibitors   (5192 occurrences)
Anticonvulsants   (5173 occurrences)
Intracellular adhesion molecule-1   (5164 occurrences)
Angiogenesis Inhibitors   (5126 occurrences)
NF-kappaB Inhibitor   (5103 occurrences)
P21 Activation   (4982 occurrences)
Spermatogenic   (4442 occurrences)
Secretagogue   (4409 occurrences)
Immunostimulatory   (4191 occurrences)
Proteasome Inhibitors   (4147 occurrences)
5-Lipoxygenase Inhibitor   (4013 occurrences)
Serotonin Agonists   (3918 occurrences)
Monoaminergic   (3845 occurrences)
Muscarinic Agonists   (3844 occurrences)
Muscarinic Antagonists   (3816 occurrences)
Anti-atherogenic   (3791 occurrences)
Radiopharmaceuticals   (3515 occurrences)
Erythropoietic   (3473 occurrences)
Hepatoprotective   (3280 occurrences)
Cholinergic Antagonists   (3263 occurrences)
Ribonucleotide Reductase Inhibitor   (3248 occurrences)
Anti-Androgen   (3214 occurrences)
Lipoxygenase Inhibitors   (3212 occurrences)
Aromatase Inhibitors   (3208 occurrences)
Superoxide Scavenger   (3199 occurrences)
Anti-Allergic   (3132 occurrences)
Hypolipidemic   (3019 occurrences)
Acetylcholinesterase Inhibitor   (3012 occurrences)
Aldose reductase inhibitor   (3001 occurrences)
Chymotrypsin Inhibitor   (2995 occurrences)
Disinfectants   (2983 occurrences)
Anti-Fibrotic   (2970 occurrences)
Anti-metastatic   (2742 occurrences)
Anti-pyretic   (2669 occurrences)
Anti-Ulcer   (2666 occurrences)
Muscle Relaxants   (2574 occurrences)
Cholinesterase Inhibitors   (2549 occurrences)
Thermogenic   (2483 occurrences)
Antiparasitic   (2335 occurrences)
Antimycobacterial   (2313 occurrences)
Antimalarials   (2274 occurrences)
Autophagy Up-regulation   (2268 occurrences)
Iron Chelating   (2251 occurrences)
Anticarcinogenic   (2230 occurrences)
Radioprotective   (2214 occurrences)
Antacids   (2107 occurrences)
Anti-Estrogenic   (2059 occurrences)
Anti-Infective   (1981 occurrences)
Renoprotective   (1952 occurrences)
Antidepressive   (1866 occurrences)
Antimitotic   (1850 occurrences)
STAT3 Inhibitor   (1828 occurrences)
Metal Chelation   (1739 occurrences)
Photosensitizing   (1736 occurrences)
Antitubercular   (1724 occurrences)
PPAR-Gamma Up-Regulation   (1703 occurrences)
Laxative   (1685 occurrences)
Drug synergy   (1662 occurrences)
Antiemetics   (1660 occurrences)
E-cadherin down-regulation   (1649 occurrences)
Antimutagenic   (1609 occurrences)
Leukotriene Antagonists   (1539 occurrences)
Gastroprotective   (1466 occurrences)
Estrogen Antagonists   (1383 occurrences)
Cardiotonic   (1378 occurrences)
Tocolytic   (1377 occurrences)
Anti-Asthmatic   (1299 occurrences)
Cytotoxins   (1241 occurrences)
Anti-Anxiety   (1230 occurrences)
Radiosensitizer   (1225 occurrences)
Trypanocidal   (1224 occurrences)
Bronchoconstrictor   (1224 occurrences)
Photoprotective   (1154 occurrences)
Teratogens   (1073 occurrences)
Interferon Inducers   (1008 occurrences)
Antitussive   (937 occurrences)
GABA Modulators   (889 occurrences)
12-lipoxygenase   (882 occurrences)
Bcl-xL down-regulation   (861 occurrences)
Ergogenic   (845 occurrences)
Androgen Antagonists   (844 occurrences)
Antiprotozoal   (836 occurrences)
Survivin Down-Regulation   (804 occurrences)
Antispasmodic   (799 occurrences)
Mucolytic   (766 occurrences)
Alpha-glucosidase inhibitor   (720 occurrences)
Telomerase Inhibitor   (678 occurrences)
Leishmanicidal   (641 occurrences)
Alpha-amylase inhibitor   (641 occurrences)
Uterotonic   (606 occurrences)
Sulfonation   (603 occurrences)
Abortifacient   (600 occurrences)
Insulin Sensitizers   (589 occurrences)
Tyrosinase inhibitors   (526 occurrences)
Chondroprotective   (514 occurrences)
Vasoprotective   (492 occurrences)
Spasmogenic   (492 occurrences)
Hypomethylating   (479 occurrences)
Anti-Arrhythmia   (476 occurrences)
Insulin-releasing   (461 occurrences)
Neuritogenic   (442 occurrences)
Insulin-mimetic   (439 occurrences)
Hypnotics and Sedatives   (379 occurrences)
Aphrodisiac   (335 occurrences)
Enkephalinase inhibitor   (312 occurrences)
Anti-Adipogenic   (310 occurrences)
Anti-elastase   (287 occurrences)
Chemosensitizer   (263 occurrences)
SIRT1 Activator   (258 occurrences)
Telomerase Upregulation   (234 occurrences)
Neurorestorative   (212 occurrences)
Psychedelic   (206 occurrences)
NOX2 inhibitor   (201 occurrences)
Adiponectin upregulation   (168 occurrences)
Oxytocics   (161 occurrences)
Lipotropic   (152 occurrences)
Protein Kinase C Inhibitor   (143 occurrences)
Cicatrizing   (138 occurrences)
Scolicidal   (124 occurrences)
Expectorants   (123 occurrences)
5-HTergic   (122 occurrences)
Progestagenic   (122 occurrences)
Radiation-Sensitizing   (112 occurrences)
Carminative   (84 occurrences)
Topoisomerase I inhibitor   (83 occurrences)
Antidiarrheals   (80 occurrences)
Genoprotective   (78 occurrences)
Stomachic   (63 occurrences)
Insulinotrophic   (57 occurrences)
Detoxifier   (47 occurrences)
Eryptotic   (35 occurrences)
Cyclooxygenase 2 Inhibitors   (27 occurrences)
Angiotensin II Type 1 Receptor Blockers   (23 occurrences)
Antiurolithiatic   (21 occurrences)
Mitogen-activated protein kinase kinase 4   (20 occurrences)
Galactogogue   (18 occurrences)
Phospholipase D Inhibitors   (2 occurrences)