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char = ;code = 32
char = g;code = 103
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char = u;code = 117
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = S;code = 83
char = -;code = 45
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
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char = e;code = 101
char = r;code = 114
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = G;code = 71
char = S;code = 83
char = T;code = 84
char = );code = 41
char = ;code = 32
char = M;code = 77
char = 1;code = 49
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = G;code = 71
char = S;code = 83
char = T;code = 84
char = T;code = 84
char = 1;code = 49
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = y;code = 121
char = p;code = 112
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = u;code = 117
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = l;code = 108
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = k;code = 107
char = .;code = 46
result sql = Effects of glutathione S-transferase (GST) M1 and GSTT1 genotypes on urothelial cancer risk.
Effects of glutathione S-transferase (GST) M1 and GSTT1 genotypes on urothelial cancer risk.
char = T;code = 84
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char = e;code = 101
char = m;code = 109
char = b;code = 98
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = m;code = 109
char = u;code = 117
char = ;code = 32
char = c;code = 99
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = h;code = 104
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = l;code = 108
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char = a;code = 97
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = e;code = 101
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char = S;code = 83
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char = t;code = 116
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char = a;code = 97
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char = e;code = 101
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char = e;code = 101
char = ;code = 32
char = (;code = 40
char = G;code = 71
char = S;code = 83
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char = g;code = 103
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char = ;code = 32
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char = b;code = 98
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char = 5;code = 53
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char = %;code = 37
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char = d;code = 100
char = i;code = 105
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char = i;code = 105
char = d;code = 100
char = u;code = 117
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = G;code = 71
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char = T;code = 84
char = 1;code = 49
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char = ;code = 32
char = m;code = 109
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char = m;code = 109
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = h;code = 104
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = ;code = 32
char = c;code = 99
char = l;code = 108
char = a;code = 97
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char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = i;code = 105
char = c;code = 99
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char = ;code = 32
char = h;code = 104
char = a;code = 97
char = s;code = 115
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char = b;code = 98
char = e;code = 101
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char = c;code = 99
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char = b;code = 98
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char = c;code = 99
char = ,;code = 44
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char = e;code = 101
char = x;code = 120
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char = s;code = 115
char = e;code = 101
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char = ;code = 32
char = o;code = 111
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char = d;code = 100
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = d;code = 100
char = u;code = 117
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char = .;code = 46
char = ;code = 32
char = I;code = 73
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char = s;code = 115
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char = 1;code = 49
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char = 5;code = 53
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char = J;code = 74
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char = a;code = 97
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char = w;code = 119
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char = ;code = 32
char = c;code = 99
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char = l;code = 108
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char = c;code = 99
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char = c;code = 99
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char = 1;code = 49
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char = 5;code = 53
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char = h;code = 104
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char = l;code = 108
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char = h;code = 104
char = y;code = 121
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char = c;code = 99
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char = a;code = 97
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char = e;code = 101
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char = ;code = 32
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char = f;code = 102
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char = e;code = 101
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char = c;code = 99
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char = s;code = 115
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char = f;code = 102
char = ;code = 32
char = G;code = 71
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char = ;code = 32
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char = e;code = 101
char = ;code = 32
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char = R;code = 82
char = ;code = 32
char = 1;code = 49
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char = ;code = 32
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char = ;code = 32
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char = 2;code = 50
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char = .;code = 46
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char = ;code = 32
char = s;code = 115
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char = i;code = 105
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char = t;code = 116
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char = n;code = 110
char = t;code = 116
char = e;code = 101
char = r;code = 114
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char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
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char = e;code = 101
char = t;code = 116
char = w;code = 119
char = e;code = 101
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
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char = S;code = 83
char = T;code = 84
char = M;code = 77
char = 1;code = 49
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = y;code = 121
char = p;code = 112
char = e;code = 101
char = ;code = 32
char = a;code = 97
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char = ;code = 32
char = s;code = 115
char = m;code = 109
char = o;code = 111
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char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = u;code = 117
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = ;;code = 59
char = ;code = 32
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char = h;code = 104
char = e;code = 101
char = ;code = 32
char = G;code = 71
char = S;code = 83
char = T;code = 84
char = M;code = 77
char = 1;code = 49
char = ;code = 32
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char = u;code = 117
char = l;code = 108
char = l;code = 108
char = ;code = 32
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char = e;code = 101
char = n;code = 110
char = o;code = 111
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char = y;code = 121
char = p;code = 112
char = e;code = 101
char = ;code = 32
char = w;code = 119
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char = s;code = 115
char = ;code = 32
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char = s;code = 115
char = s;code = 115
char = o;code = 111
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char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = w;code = 119
char = i;code = 105
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char = h;code = 104
char = ;code = 32
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char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
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char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = k;code = 107
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = u;code = 117
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = l;code = 108
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = g;code = 103
char = ;code = 32
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char = m;code = 109
char = o;code = 111
char = k;code = 107
char = e;code = 101
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char = s;code = 115
char = ;code = 32
char = (;code = 40
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char = R;code = 82
char = ;code = 32
char = 1;code = 49
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char = 8;code = 56
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char = ;code = 32
char = 9;code = 57
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char = ;code = 32
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char = ;code = 32
char = 1;code = 49
char = .;code = 46
char = 1;code = 49
char = 0;code = 48
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char = 3;code = 51
char = .;code = 46
char = 5;code = 53
char = 7;code = 55
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result sql = The M1 member of the mu class of the glutathione S-transferase (GSTM1) gene is present in about 50% of individuals. GSTT1, a member of the theta class, which has been recently shown to be polymorphic, is expressed in 35-90% of individuals. In this study, 145 Japanese patients with urothelial transitional cell carcinoma and 145 healthy controls, frequency-matched for age and gender, were compared for frequencies of GSTM1 and GSTT1 genotypes. The urothelial cancer risk increased due to the GSTM1 null genotype (odds ratio (OR) 1.71, 95% confidence interval (CI) 1.05-2.79). On the other hand, the OR tended to decrease due to the GSTT1 null genotype, although not significantly. Among individuals of the GSTM1 null genotype, those of the GSTT1-positive genotype had a two-fold risk (OR 2.62, 95% CI 1.36-5.05) compared with the GSTT1 null genotype (OR 1.25, 95% CI 0.62-2.51). A significant interaction between the GSTM1 genotype and smoking status was found; the GSTM1 null genotype was associated with an increased risk of urothelial cancer among smokers (OR 1.98, 95% CI 1.10-3.57).

Publication: Cancer Lett. 1998 Oct 23 ;132(1-2)::147-52.
Publication Date: 1998 Oct 23
Study Author(s): Katoh, T;Inatomi, H;Kim, H;Yang, M;Matsumoto, T;Kawamoto, T;
Institution: Department of Health Information Science, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu City, Japan.
Shortcut link to this study:
The M1 member of the mu class of the glutathione S-transferase (GSTM1) gene is present in about 50% of individuals. GSTT1, a member of the theta class, which has been recently shown to be polymorphic, is expressed in 35-90% of individuals. In this study, 145 Japanese patients with urothelial transitional cell carcinoma and 145 healthy controls, frequency-matched for age and gender, were compared for frequencies of GSTM1 and GSTT1 genotypes. The urothelial cancer risk increased due to the GSTM1 null genotype (odds ratio (OR) 1.71, 95% confidence interval (CI) 1.05-2.79). On the other hand, the OR tended to decrease due to the GSTT1 null genotype, although not significantly. Among individuals of the GSTM1 null genotype, those of the GSTT1-positive genotype had a two-fold risk (OR 2.62, 95% CI 1.36-5.05) compared with the GSTT1 null genotype (OR 1.25, 95% CI 0.62-2.51). A significant interaction between the GSTM1 genotype and smoking status was found; the GSTM1 null genotype was associated with an increased risk of urothelial cancer among smokers (OR 1.98, 95% CI 1.10-3.57).
PMID: 10397466

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