|
|
char = O;code = 79
char = x;code = 120
char = y;code = 121
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char = f;code = 102
char = r;code = 114
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char = .;code = 46
result sql = Oxytocin does not induce a rise in intracellular free calcium in human breast cancer cells.
Oxytocin does not induce a rise in intracellular free calcium in human breast cancer cells.char = R;code = 82
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char = t;code = 116
char = s;code = 115
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char = t;code = 116
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char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = m;code = 109
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char = d;code = 100
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = o;code = 111
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char = y;code = 121
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char = f;code = 102
char = e;code = 101
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char = s;code = 115
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char = s;code = 115
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char = n;code = 110
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char = f;code = 102
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char = o;code = 111
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result sql = Research suggests that oxytocin acts as a growth modulating agent for breast cancer cells. However, the signaling mechanisms responsible for these modulatory effects have not been fully elucidated. In the physiological setting oxytocin is known to stimulate contraction of myometrial cells in the uterus and myoepithelial cells in the breast by increasing intracellular free calcium ([Ca2+]i). The expression of oxytocin receptor mRNA in T-47D breast cancer cells, and four additional breast cancer cell lines (BT-549, MCF-7, MDA-MB- 231, ZR-75-1), was confirmed by RT-PCR analysis. Oxytocin-induced changes in [Ca2+]i in indo-1 AM loaded T-47D breast cancer cells were monitored using flow cytometric analysis. In this cell line, oxytocin (0, 1, 10, 100, and 1,000 nM) did not induce a dose-dependent increase in the mean 405 nm/485 nm emission ratio. These results indicate that oxytocin signaling in T-47D breast cancer cells does not appear to involve an increase in [Ca2+]i.
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char = n;code = 110
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char = c;code = 99
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result sql = Oxytocin does not induce a rise in intracellular free calcium in human breast cancer cells.
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result sql = Research suggests that oxytocin acts as a growth modulating agent for breast cancer cells. However, the signaling mechanisms responsible for these modulatory effects have not been fully elucidated. In the physiological setting oxytocin is known to stimulate contraction of myometrial cells in the uterus and myoepithelial cells in the breast by increasing intracellular free calcium ([Ca2+]i). The expression of oxytocin receptor mRNA in T-47D breast cancer cells, and four additional breast cancer cell lines (BT-549, MCF-7, MDA-MB- 231, ZR-75-1), was confirmed by RT-PCR analysis. Oxytocin-induced changes in [Ca2+]i in indo-1 AM loaded T-47D breast cancer cells were monitored using flow cytometric analysis. In this cell line, oxytocin (0, 1, 10, 100, and 1,000 nM) did not induce a dose-dependent increase in the mean 405 nm/485 nm emission ratio. These results indicate that oxytocin signaling in T-47D breast cancer cells does not appear to involve an increase in [Ca2+]i.
Publication: Res. Commun. Mol. Pathol. Pharmacol. 1999 Feb ;103(2)::115-28.
Publication Date: 1999 Feb
Study Author(s): Fay, M J;Du, J;Longo, K A;North, W G;
Institution: Department of Pharmacology, Midwestern University, Downers Grove, IL 60515, USA. [email protected]
Shortcut link to this study:
Publication Date: 1999 Feb
Study Author(s): Fay, M J;Du, J;Longo, K A;North, W G;
Institution: Department of Pharmacology, Midwestern University, Downers Grove, IL 60515, USA. [email protected]
Shortcut link to this study:
Research suggests that oxytocin acts as a growth modulating agent for breast cancer cells. However, the signaling mechanisms responsible for these modulatory effects have not been fully elucidated. In the physiological setting oxytocin is known to stimulate contraction of myometrial cells in the uterus and myoepithelial cells in the breast by increasing intracellular free calcium ([Ca2+]i). The expression of oxytocin receptor mRNA in T-47D breast cancer cells, and four additional breast cancer cell lines (BT-549, MCF-7, MDA-MB- 231, ZR-75-1), was confirmed by RT-PCR analysis. Oxytocin-induced changes in [Ca2+]i in indo-1 AM loaded T-47D breast cancer cells were monitored using flow cytometric analysis. In this cell line, oxytocin (0, 1, 10, 100, and 1,000 nM) did not induce a dose-dependent increase in the mean 405 nm/485 nm emission ratio. These results indicate that oxytocin signaling in T-47D breast cancer cells does not appear to involve an increase in [Ca2+]i.
PMID: 10461679
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