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|
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result sql = Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C.
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result sql = Twenty resveratrol (3,5,4'-trihydroxystilbene) (Res) derivatives, which were isolated from stem bark of Vatica rassak (Dipterocarpaceae), were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. Among them, seven compounds displayed marked cytotoxicity. Vaticanol C (Vat C) as a major component induced a considerable cytotoxicity in all cell lines tested and exhibited growth suppression in colon cancer cell lines at low dose. Vat C caused two cell lines (SW480 and HL60) to induce cell death at four to seven times lower concentrations, compared with Res. The growth suppression by Vat C was found to be due to apoptosis, which was assessed by morphological findings (nuclear condensation and fragmentation) and DNA ladder formation in the colon cancer cell lines. The apoptosis in SW480 colon cancer cells was executed by the activation of caspase-3, which was shown by western blot and apoptosis inhibition assay. Furthermore, the mitochondrial membrane potential of apoptotic SW480 cells after 12 h treatment with Vat C was significantly lost, and concurrently the cytochrome c release and activation of caspase-9 were also detected by western blot analysis. Over-expression of Bcl-2 protein in SW480 cells significantly prevented the cell death induced by Vat C. Taken together, the findings presented here indicate that Vat C induced marked apoptosis in malignant cells mainly by affecting mitochondrial membrane potential.
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char = C;code = 67
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result sql = Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C.
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char = a;code = 97
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char = V;code = 86
char = a;code = 97
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char = c;code = 99
char = a;code = 97
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char = a;code = 97
char = s;code = 115
char = s;code = 115
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char = e;code = 101
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char = a;code = 97
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char = u;code = 117
char = a;code = 97
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char = l;code = 108
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char = l;code = 108
char = i;code = 105
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char = s;code = 115
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char = A;code = 65
char = m;code = 109
char = o;code = 111
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char = s;code = 115
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char = e;code = 101
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char = o;code = 111
char = m;code = 109
char = p;code = 112
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char = d;code = 100
char = s;code = 115
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char = d;code = 100
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char = s;code = 115
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char = a;code = 97
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char = e;code = 101
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char = m;code = 109
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = c;code = 99
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char = t;code = 116
char = o;code = 111
char = t;code = 116
char = o;code = 111
char = x;code = 120
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char = c;code = 99
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = ;code = 32
char = V;code = 86
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = C;code = 67
char = ;code = 32
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char = V;code = 86
char = a;code = 97
char = t;code = 116
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char = C;code = 67
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char = ;code = 32
char = a;code = 97
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
char = j;code = 106
char = o;code = 111
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char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
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char = t;code = 116
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char = i;code = 105
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char = u;code = 117
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
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char = c;code = 99
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char = s;code = 115
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char = d;code = 100
char = e;code = 101
char = r;code = 114
char = a;code = 97
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char = l;code = 108
char = e;code = 101
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char = c;code = 99
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char = o;code = 111
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char = c;code = 99
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char = l;code = 108
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char = l;code = 108
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char = s;code = 115
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char = t;code = 116
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char = p;code = 112
char = p;code = 112
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char = c;code = 99
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char = l;code = 108
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char = l;code = 108
char = i;code = 105
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char = a;code = 97
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char = ;code = 32
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char = w;code = 119
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char = d;code = 100
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char = e;code = 101
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char = V;code = 86
char = a;code = 97
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char = C;code = 67
char = ;code = 32
char = c;code = 99
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char = s;code = 115
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char = d;code = 100
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char = S;code = 83
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char = L;code = 76
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char = h;code = 104
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char = R;code = 82
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = g;code = 103
char = r;code = 114
char = o;code = 111
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char = t;code = 116
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char = s;code = 115
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char = o;code = 111
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char = b;code = 98
char = y;code = 121
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char = V;code = 86
char = a;code = 97
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char = ;code = 32
char = C;code = 67
char = ;code = 32
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char = a;code = 97
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char = e;code = 101
char = s;code = 115
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char = e;code = 101
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char = D;code = 68
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char = F;code = 70
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char = p;code = 112
char = o;code = 111
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result sql = Twenty resveratrol (3,5,4'-trihydroxystilbene) (Res) derivatives, which were isolated from stem bark of Vatica rassak (Dipterocarpaceae), were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. Among them, seven compounds displayed marked cytotoxicity. Vaticanol C (Vat C) as a major component induced a considerable cytotoxicity in all cell lines tested and exhibited growth suppression in colon cancer cell lines at low dose. Vat C caused two cell lines (SW480 and HL60) to induce cell death at four to seven times lower concentrations, compared with Res. The growth suppression by Vat C was found to be due to apoptosis, which was assessed by morphological findings (nuclear condensation and fragmentation) and DNA ladder formation in the colon cancer cell lines. The apoptosis in SW480 colon cancer cells was executed by the activation of caspase-3, which was shown by western blot and apoptosis inhibition assay. Furthermore, the mitochondrial membrane potential of apoptotic SW480 cells after 12 h treatment with Vat C was significantly lost, and concurrently the cytochrome c release and activation of caspase-9 were also detected by western blot analysis. Over-expression of Bcl-2 protein in SW480 cells significantly prevented the cell death induced by Vat C. Taken together, the findings presented here indicate that Vat C induced marked apoptosis in malignant cells mainly by affecting mitochondrial membrane potential.
Publication: Carcinogenesis 2003 Sep ;24(9)::1489-97.
Publication Date: 2003 Sep
Study Author(s): Ito, Tetsuro;Akao, Yukihiro;Yi, Hong;Ohguchi, Kenji;Matsumoto, Kenji;Tanaka, Toshiyuki;Iinuma, Munekazu;Nozawa, Yoshinori;
Institution: Gifu International Institute of Biotechnology, Mitake, Kani-gun, Gifu 505-0116, Japan.
Shortcut link to this study:
Publication Date: 2003 Sep
Study Author(s): Ito, Tetsuro;Akao, Yukihiro;Yi, Hong;Ohguchi, Kenji;Matsumoto, Kenji;Tanaka, Toshiyuki;Iinuma, Munekazu;Nozawa, Yoshinori;
Institution: Gifu International Institute of Biotechnology, Mitake, Kani-gun, Gifu 505-0116, Japan.
Shortcut link to this study:
Twenty resveratrol (3,5,4'-trihydroxystilbene) (Res) derivatives, which were isolated from stem bark of Vatica rassak (Dipterocarpaceae), were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. Among them, seven compounds displayed marked cytotoxicity. Vaticanol C (Vat C) as a major component induced a considerable cytotoxicity in all cell lines tested and exhibited growth suppression in colon cancer cell lines at low dose. Vat C caused two cell lines (SW480 and HL60) to induce cell death at four to seven times lower concentrations, compared with Res. The growth suppression by Vat C was found to be due to apoptosis, which was assessed by morphological findings (nuclear condensation and fragmentation) and DNA ladder formation in the colon cancer cell lines. The apoptosis in SW480 colon cancer cells was executed by the activation of caspase-3, which was shown by western blot and apoptosis inhibition assay. Furthermore, the mitochondrial membrane potential of apoptotic SW480 cells after 12 h treatment with Vat C was significantly lost, and concurrently the cytochrome c release and activation of caspase-9 were also detected by western blot analysis. Over-expression of Bcl-2 protein in SW480 cells significantly prevented the cell death induced by Vat C. Taken together, the findings presented here indicate that Vat C induced marked apoptosis in malignant cells mainly by affecting mitochondrial membrane potential.
PMID: 12844481
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