|
|
char = H;code = 72
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result sql = High curative resection rate with weekly cisplatin, 5-fluorouracil, epidoxorubicin, 6S-leucovorin, glutathione, and filgastrim in patients with locally advanced, unresectable gastric cancer: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD).
High curative resection rate with weekly cisplatin, 5-fluorouracil, epidoxorubicin, 6S-leucovorin, glutathione, and filgastrim in patients with locally advanced, unresectable gastric cancer: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD).char = T;code = 84
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result sql = The aim of the present study was to evaluate the role of a weekly preoperative chemotherapy in locally advanced, unresectable gastric cancer. In all, 82 patients with an Eastern Oncology Cooperative Group PS CHEMOTHERAPY TREATMENT WAS: cisplatin 40 mg x m(-2); 5-fluorouracil 500 mg x m(-2); epidoxorubicin 35 mg x m(-2); 6S-leucovorin 250 mg x m(-2) and glutathione 1.5 g x m(-2) (PELF). One cycle consisted of 8 weekly treatments. Response to chemotherapy was observed in 40 of 82 patients (49%): six (7%) complete and 34 (41%) partial responses, and in four (5%) cases a complete pathological response was confirmed. Of the 40 responding patients, 37 (45%) had potentially curative surgery. Grade 3/4 leucopenia and thrombocytopenia occurred in three and two patients. At a median follow-up of 48 months, 25 of the 37 resected patients (68%) were alive and 24 (65%) were disease free. The median and 4-year survival for the whole group was 17 months and 31%, respectively. The median survival was 12 months for inoperable patients and it was not reached in resected patients.
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char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = h;code = 104
char = e;code = 101
char = ;code = 32
char = S;code = 83
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = D;code = 68
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char = g;code = 103
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char = v;code = 118
char = e;code = 101
char = ;code = 32
char = T;code = 84
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = C;code = 67
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = (;code = 40
char = G;code = 71
char = I;code = 73
char = S;code = 83
char = C;code = 67
char = A;code = 65
char = D;code = 68
char = );code = 41
char = .;code = 46
result sql = High curative resection rate with weekly cisplatin, 5-fluorouracil, epidoxorubicin, 6S-leucovorin, glutathione, and filgastrim in patients with locally advanced, unresectable gastric cancer: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD).
char = h;code = 104
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char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
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char = I;code = 73
char = n;code = 110
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char = l;code = 108
char = ,;code = 44
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char = 8;code = 56
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char = C;code = 67
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char = P;code = 80
char = Y;code = 89
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char = W;code = 87
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char = <;code = 60
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result sql = The aim of the present study was to evaluate the role of a weekly preoperative chemotherapy in locally advanced, unresectable gastric cancer. In all, 82 patients with an Eastern Oncology Cooperative Group PS
Publication: Br. J. Cancer 2004 Apr 19 ;90(8)::1521-5.
Publication Date: 2004 Apr 19
Study Author(s): Cascinu, S;Scartozzi, M;Labianca, R;Catalano, V;Silva, R R;Barni, S;Zaniboni, A;D'Angelo, A;Salvagni, S;Martignoni, G;Beretta, G D;Graziano, F;Berardi, R;Franciosi, V;Italian Group for the Study of Digestive Tract Cancer (GISCAD);
Institution: Clinica di Oncologia, Università Politecnica delle Marche-Azienda Ospedaliera Umberto I, via Conca, Ancona 60020, Italy. [email protected]
Shortcut link to this study:
Publication Date: 2004 Apr 19
Study Author(s): Cascinu, S;Scartozzi, M;Labianca, R;Catalano, V;Silva, R R;Barni, S;Zaniboni, A;D'Angelo, A;Salvagni, S;Martignoni, G;Beretta, G D;Graziano, F;Berardi, R;Franciosi, V;Italian Group for the Study of Digestive Tract Cancer (GISCAD);
Institution: Clinica di Oncologia, Università Politecnica delle Marche-Azienda Ospedaliera Umberto I, via Conca, Ancona 60020, Italy. [email protected]
Shortcut link to this study:
The aim of the present study was to evaluate the role of a weekly preoperative chemotherapy in locally advanced, unresectable gastric cancer. In all, 82 patients with an Eastern Oncology Cooperative Group PS CHEMOTHERAPY TREATMENT WAS: cisplatin 40 mg x m(-2); 5-fluorouracil 500 mg x m(-2); epidoxorubicin 35 mg x m(-2); 6S-leucovorin 250 mg x m(-2) and glutathione 1.5 g x m(-2) (PELF). One cycle consisted of 8 weekly treatments. Response to chemotherapy was observed in 40 of 82 patients (49%): six (7%) complete and 34 (41%) partial responses, and in four (5%) cases a complete pathological response was confirmed. Of the 40 responding patients, 37 (45%) had potentially curative surgery. Grade 3/4 leucopenia and thrombocytopenia occurred in three and two patients. At a median follow-up of 48 months, 25 of the 37 resected patients (68%) were alive and 24 (65%) were disease free. The median and 4-year survival for the whole group was 17 months and 31%, respectively. The median survival was 12 months for inoperable patients and it was not reached in resected patients.
PMID: 15083179
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