|
|
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result sql = Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasound.
Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasound.char = B;code = 66
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result sql = Bioflavonoids, such as quercetin, have recently emerged as a new class of chemotherapeutic drugs for the treatment of various cancer types, but are marred by their low potency and poor selectivity. We report that a short application of low-frequency ultrasound selectively sensitises prostate and skin cancer cells against quercetin. Pretreatment of cells with ultrasound (20 kHz, 2 W cm(-2), 60 s) selectively induced cytotoxicity in skin and prostate cancer cells, while having minimal effect on corresponding normal cell lines. About 90% of the viable skin cancer cell population was lost within 48 h after ultrasound-quercetin (50 microM) treatment. Ultrasound reduced the LC50 of quercetin for skin cancer cells by almost 80-fold, while showing no effect on LC50 for nonmalignant skin cells.
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result sql = Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasound.
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result sql = Bioflavonoids, such as quercetin, have recently emerged as a new class of chemotherapeutic drugs for the treatment of various cancer types, but are marred by their low potency and poor selectivity. We report that a short application of low-frequency ultrasound selectively sensitises prostate and skin cancer cells against quercetin. Pretreatment of cells with ultrasound (20 kHz, 2 W cm(-2), 60 s) selectively induced cytotoxicity in skin and prostate cancer cells, while having minimal effect on corresponding normal cell lines. About 90% of the viable skin cancer cell population was lost within 48 h after ultrasound-quercetin (50 microM) treatment. Ultrasound reduced the LC50 of quercetin for skin cancer cells by almost 80-fold, while showing no effect on LC50 for nonmalignant skin cells.
Publication: Br. J. Cancer 2005 Feb 14 ;92(3)::499-502.
Publication Date: 2005 Feb 14
Study Author(s): Paliwal, S;Sundaram, J;Mitragotri, S;
Institution: Department of Chemical Engineering, University of California, Santa Barbara, CA 93106-5080, USA.
Shortcut link to this study:
Publication Date: 2005 Feb 14
Study Author(s): Paliwal, S;Sundaram, J;Mitragotri, S;
Institution: Department of Chemical Engineering, University of California, Santa Barbara, CA 93106-5080, USA.
Shortcut link to this study:
Bioflavonoids, such as quercetin, have recently emerged as a new class of chemotherapeutic drugs for the treatment of various cancer types, but are marred by their low potency and poor selectivity. We report that a short application of low-frequency ultrasound selectively sensitises prostate and skin cancer cells against quercetin. Pretreatment of cells with ultrasound (20 kHz, 2 W cm(-2), 60 s) selectively induced cytotoxicity in skin and prostate cancer cells, while having minimal effect on corresponding normal cell lines. About 90% of the viable skin cancer cell population was lost within 48 h after ultrasound-quercetin (50 microM) treatment. Ultrasound reduced the LC50 of quercetin for skin cancer cells by almost 80-fold, while showing no effect on LC50 for nonmalignant skin cells.
PMID: 15685239
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