|
|
char = R;code = 82
char = e;code = 101
char = s;code = 115
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = -;code = 45
char = i;code = 105
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char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
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char = i;code = 105
char = n;code = 110
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char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
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char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = M;code = 77
char = C;code = 67
char = F;code = 70
char = 7;code = 55
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char = h;code = 104
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char = r;code = 114
char = e;code = 101
char = a;code = 97
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char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
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char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = m;code = 109
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char = d;code = 100
char = u;code = 117
char = l;code = 108
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char = o;code = 111
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char = ;code = 32
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char = o;code = 111
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char = p;code = 112
char = h;code = 104
char = o;code = 111
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char = y;code = 121
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char = e;code = 101
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char = k;code = 107
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char = p;code = 112
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char = e;code = 101
char = -;code = 45
char = 9;code = 57
char = .;code = 46
result sql = Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9.
Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9.char = R;code = 82
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char = s;code = 115
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = a;code = 97
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char = r;code = 114
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = (;code = 40
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = -;code = 45
char = 3;code = 51
char = ,;code = 44
char = 4;code = 52
char = N;code = 78
char = ,;code = 44
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char = o;code = 111
char = a;code = 97
char = l;code = 108
char = e;code = 101
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char = r;code = 114
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char = e;code = 101
char = m;code = 109
char = e;code = 101
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char = n;code = 110
char = g;code = 103
char = ;code = 32
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char = ;code = 32
char = a;code = 97
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char = n;code = 110
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char = a;code = 97
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char = o;code = 111
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char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = n;code = 110
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char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
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char = r;code = 114
char = ;code = 32
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char = r;code = 114
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char = t;code = 116
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char = h;code = 104
char = a;code = 97
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char = ;code = 32
char = M;code = 77
char = C;code = 67
char = F;code = 70
char = 7;code = 55
char = ;code = 32
char = i;code = 105
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char = t;code = 116
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result sql = Resveratrol (trans-3,4N,-5-trihydroxystilbene), a phytoalexin present in grapes and red wine, is emerging as a natural compound with potential anticancer properties. Here we show that resveratrol affects the growth of human breast cancer cell lines MCF7, MDA-MB-231, SK-BR-3, and Bcap-37 in a dose-dependent manner and that MCF7 is the most sensitive among the four cell lines. MCF7 cells treated with resveratrol showed typical characteristics of apoptosis including the poly (ADP-ribose) polymerase cleavage, TdT-mediated dUTP nick end labeling-positive staining, and morphologic changes. Phosphorylation of the oncogene product Akt was significantly reduced followed by decreased phosphorylation and increased processing of pro-caspase-9 on resveratrol treatment. These results indicate that resveratrol seems to exert its growth-inhibitory/apoptotic effect on the breast cancer cell line MCF7 via the Akt-caspase-9 pathway.
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result sql = Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9.
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result sql = Resveratrol (trans-3,4N,-5-trihydroxystilbene), a phytoalexin present in grapes and red wine, is emerging as a natural compound with potential anticancer properties. Here we show that resveratrol affects the growth of human breast cancer cell lines MCF7, MDA-MB-231, SK-BR-3, and Bcap-37 in a dose-dependent manner and that MCF7 is the most sensitive among the four cell lines. MCF7 cells treated with resveratrol showed typical characteristics of apoptosis including the poly (ADP-ribose) polymerase cleavage, TdT-mediated dUTP nick end labeling-positive staining, and morphologic changes. Phosphorylation of the oncogene product Akt was significantly reduced followed by decreased phosphorylation and increased processing of pro-caspase-9 on resveratrol treatment. These results indicate that resveratrol seems to exert its growth-inhibitory/apoptotic effect on the breast cancer cell line MCF7 via the Akt-caspase-9 pathway.
Publication: Appl. Biochem. Biotechnol. 2006 Dec ;135(3)::181-92.
Publication Date: 2006 Dec
Study Author(s): Li, Yan;Liu, Junye;Liu, Xinping;Xing, Kefei;Wang, Yun;Li, Fuyang;Yao, Libo;
Institution: Department of Biochemistry and Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an 710032, China.
Shortcut link to this study:
Publication Date: 2006 Dec
Study Author(s): Li, Yan;Liu, Junye;Liu, Xinping;Xing, Kefei;Wang, Yun;Li, Fuyang;Yao, Libo;
Institution: Department of Biochemistry and Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an 710032, China.
Shortcut link to this study:
Resveratrol (trans-3,4N,-5-trihydroxystilbene), a phytoalexin present in grapes and red wine, is emerging as a natural compound with potential anticancer properties. Here we show that resveratrol affects the growth of human breast cancer cell lines MCF7, MDA-MB-231, SK-BR-3, and Bcap-37 in a dose-dependent manner and that MCF7 is the most sensitive among the four cell lines. MCF7 cells treated with resveratrol showed typical characteristics of apoptosis including the poly (ADP-ribose) polymerase cleavage, TdT-mediated dUTP nick end labeling-positive staining, and morphologic changes. Phosphorylation of the oncogene product Akt was significantly reduced followed by decreased phosphorylation and increased processing of pro-caspase-9 on resveratrol treatment. These results indicate that resveratrol seems to exert its growth-inhibitory/apoptotic effect on the breast cancer cell line MCF7 via the Akt-caspase-9 pathway.
PMID: 17299206
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