|
|
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result sql = The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo.
The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo.char = C;code = 67
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char = o;code = 111
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char = u;code = 117
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char = M;code = 77
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char = a;code = 97
char = n;code = 110
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char = M;code = 77
char = M;code = 77
char = P;code = 80
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char = a;code = 97
char = c;code = 99
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char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = n;code = 110
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char = h;code = 104
char = e;code = 101
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char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
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char = b;code = 98
char = e;code = 101
char = a;code = 97
char = r;code = 114
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char = n;code = 110
char = g;code = 103
char = ;code = 32
char = s;code = 115
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char = t;code = 116
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char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = m;code = 109
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char = a;code = 97
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = o;code = 111
char = d;code = 100
char = u;code = 117
char = l;code = 108
char = e;code = 101
char = s;code = 115
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char = i;code = 105
char = n;code = 110
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char = v;code = 118
char = i;code = 105
char = v;code = 118
char = o;code = 111
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char = w;code = 119
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char = e;code = 101
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = ;code = 32
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char = e;code = 101
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char = u;code = 117
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char = i;code = 105
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char = e;code = 101
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char = g;code = 103
char = r;code = 114
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char = u;code = 117
char = n;code = 110
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char = a;code = 97
char = t;code = 116
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char = d;code = 100
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char = o;code = 111
char = u;code = 117
char = p;code = 112
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char = ;code = 32
char = C;code = 67
char = u;code = 117
char = r;code = 114
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char = u;code = 117
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char = n;code = 110
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char = p;code = 112
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char = c;code = 99
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char = t;code = 116
char = u;code = 117
char = t;code = 116
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char = r;code = 114
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char = e;code = 101
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char = t;code = 116
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char = o;code = 111
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char = e;code = 101
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char = i;code = 105
char = t;code = 116
char = i;code = 105
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char = l;code = 108
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char = s;code = 115
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char = t;code = 116
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char = s;code = 115
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char = i;code = 105
char = n;code = 110
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char = p;code = 112
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char = t;code = 116
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char = t;code = 116
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result sql = Curcumin has become a focus of interest with regard to its antitumor effects in prostate cancer; however, the effects of this agent on invasion and metastasis remain less well understood. Matrix metalloproteinases (MMPs) are important prerequisite for tumor invasion and metastasis. In this study, we evaluated the effects of curcumin on prostate cancer cells (DU-145) invasion in both in vitro and in vivo. We utilized zymography and ELISA in order to determine the MMP-2 and MMP-9 activity. Matrigel invasion assay was performed to assess cellular invasion. We developed a xenograft model to examine tumorigenicity. Curcumin treatment resulted not only in a significant reduction in the expression of MMP-2 and MMP-9, but also effected the inhibition of invasive ability in vitro. Curcumin was shown to induce a marked reduction of tumor volume, MMP-2, and MMP-9 activity in the tumor-bearing site. The metastatic nodules in vivo were significantly fewer in the curcumin-treated group than untreated group. Curcumin appears to constitute a potential agent for the prevention of cancer progression, or at least of the initial phase of metastasis, in prostate cancer.
char = h;code = 104
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char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = r;code = 114
char = c;code = 99
char = u;code = 117
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = n;code = 110
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char = i;code = 105
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = e;code = 101
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char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = s;code = 115
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char = a;code = 97
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char = e;code = 101
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char = c;code = 99
char = a;code = 97
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char = c;code = 99
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = i;code = 105
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char = n;code = 110
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = v;code = 118
char = o;code = 111
char = .;code = 46
result sql = The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo.
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result sql = Curcumin has become a focus of interest with regard to its antitumor effects in prostate cancer; however, the effects of this agent on invasion and metastasis remain less well understood. Matrix metalloproteinases (MMPs) are important prerequisite for tumor invasion and metastasis. In this study, we evaluated the effects of curcumin on prostate cancer cells (DU-145) invasion in both in vitro and in vivo. We utilized zymography and ELISA in order to determine the MMP-2 and MMP-9 activity. Matrigel invasion assay was performed to assess cellular invasion. We developed a xenograft model to examine tumorigenicity. Curcumin treatment resulted not only in a significant reduction in the expression of MMP-2 and MMP-9, but also effected the inhibition of invasive ability in vitro. Curcumin was shown to induce a marked reduction of tumor volume, MMP-2, and MMP-9 activity in the tumor-bearing site. The metastatic nodules in vivo were significantly fewer in the curcumin-treated group than untreated group. Curcumin appears to constitute a potential agent for the prevention of cancer progression, or at least of the initial phase of metastasis, in prostate cancer.
Publication: Prostate Cancer Prostatic Dis. 2006 ;9(2)::147-52.
Publication Date: 2006
Study Author(s): Hong, J H;Ahn, K S;Bae, E;Jeon, S S;Choi, H Y;
Institution: Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Shortcut link to this study:
Publication Date: 2006
Study Author(s): Hong, J H;Ahn, K S;Bae, E;Jeon, S S;Choi, H Y;
Institution: Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Shortcut link to this study:
Curcumin has become a focus of interest with regard to its antitumor effects in prostate cancer; however, the effects of this agent on invasion and metastasis remain less well understood. Matrix metalloproteinases (MMPs) are important prerequisite for tumor invasion and metastasis. In this study, we evaluated the effects of curcumin on prostate cancer cells (DU-145) invasion in both in vitro and in vivo. We utilized zymography and ELISA in order to determine the MMP-2 and MMP-9 activity. Matrigel invasion assay was performed to assess cellular invasion. We developed a xenograft model to examine tumorigenicity. Curcumin treatment resulted not only in a significant reduction in the expression of MMP-2 and MMP-9, but also effected the inhibition of invasive ability in vitro. Curcumin was shown to induce a marked reduction of tumor volume, MMP-2, and MMP-9 activity in the tumor-bearing site. The metastatic nodules in vivo were significantly fewer in the curcumin-treated group than untreated group. Curcumin appears to constitute a potential agent for the prevention of cancer progression, or at least of the initial phase of metastasis, in prostate cancer.
PMID: 16389264
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