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result sql = Differential modulation of cyclooxygenase-mediated prostaglandin production by the putative cancer chemopreventive flavonoids tricin, apigenin and quercetin.
Differential modulation of cyclooxygenase-mediated prostaglandin production by the putative cancer chemopreventive flavonoids tricin, apigenin and quercetin.
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char = l;code = 108
char = l;code = 108
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char = E;code = 69
char = C;code = 67
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char = );code = 41
char = ;code = 32
char = P;code = 80
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char = v;code = 118
char = e;code = 101
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char = c;code = 99
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char = l;code = 108
char = u;code = 117
char = l;code = 108
char = a;code = 97
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char = b;code = 98
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char = >;code = 62
char = <;code = 60
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char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = R;code = 82
char = E;code = 69
char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
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char = b;code = 98
char = >;code = 62
char = T;code = 84
char = r;code = 114
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char = c;code = 99
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char = n;code = 110
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char = a;code = 97
char = n;code = 110
char = d;code = 100
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char = q;code = 113
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char = e;code = 101
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char = i;code = 105
char = n;code = 110
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char = i;code = 105
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char = t;code = 116
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char = i;code = 105
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char = ;code = 32
char = p;code = 112
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char = f;code = 102
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char = e;code = 101
char = d;code = 100
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char = C;code = 67
char = O;code = 79
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char = -;code = 45
char = 1;code = 49
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char = a;code = 97
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char = d;code = 100
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char = 2;code = 50
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char = p;code = 112
char = r;code = 114
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char = p;code = 112
char = a;code = 97
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = s;code = 115
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = I;code = 73
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char = 5;code = 53
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char = v;code = 118
char = a;code = 97
char = l;code = 108
char = u;code = 117
char = e;code = 101
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = n;code = 110
char = e;code = 101
char = a;code = 97
char = r;code = 114
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char = 1;code = 49
char = ;code = 32
char = (;code = 40
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = c;code = 99
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char = n;code = 110
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = 5;code = 53
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char = m;code = 109
char = i;code = 105
char = c;code = 99
char = r;code = 114
char = o;code = 111
char = M;code = 77
char = ;code = 32
char = (;code = 40
char = q;code = 113
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char = e;code = 101
char = r;code = 114
char = c;code = 99
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = n;code = 110
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char = .;code = 46
char = ;code = 32
char = A;code = 65
char = p;code = 112
char = i;code = 105
char = g;code = 103
char = e;code = 101
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char = i;code = 105
char = n;code = 110
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char = a;code = 97
char = t;code = 116
char = ;code = 32
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = 2;code = 50
char = 5;code = 53
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = c;code = 99
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char = d;code = 100
char = i;code = 105
char = d;code = 100
char = ;code = 32
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char = a;code = 97
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = C;code = 67
char = O;code = 79
char = X;code = 88
char = ;code = 32
char = e;code = 101
char = n;code = 110
char = z;code = 122
char = y;code = 121
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char = e;code = 101
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char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
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char = ;code = 32
char = F;code = 70
char = l;code = 108
char = a;code = 97
char = v;code = 118
char = o;code = 111
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char = o;code = 111
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char = d;code = 100
char = s;code = 115
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char = w;code = 119
char = e;code = 101
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char = e;code = 101
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char = i;code = 105
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char = b;code = 98
char = a;code = 97
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char = t;code = 116
char = h;code = 104
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char = c;code = 99
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char = l;code = 108
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char = r;code = 114
char = ;code = 32
char = 6;code = 54
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char = 2;code = 50
char = 4;code = 52
char = ;code = 32
char = h;code = 104
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = C;code = 67
char = O;code = 79
char = X;code = 88
char = -;code = 45
char = 2;code = 50
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char = p;code = 112
char = r;code = 114
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char = t;code = 116
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char = e;code = 101
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char = s;code = 115
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char = o;code = 111
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char = a;code = 97
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char = e;code = 101
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char = s;code = 115
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char = s;code = 115
char = s;code = 115
char = e;code = 101
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char = W;code = 87
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char = t;code = 116
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char = s;code = 115
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char = v;code = 118
char = e;code = 101
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char = y;code = 121
char = .;code = 46
char = ;code = 32
char = N;code = 78
char = o;code = 111
char = n;code = 110
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = e;code = 101
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char = f;code = 102
char = e;code = 101
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char = t;code = 116
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char = e;code = 101
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char = C;code = 67
char = O;code = 79
char = X;code = 88
char = -;code = 45
char = 2;code = 50
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char = e;code = 101
char = x;code = 120
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char = n;code = 110
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char = i;code = 105
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char = H;code = 72
char = C;code = 67
char = A;code = 65
char = -;code = 45
char = 7;code = 55
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
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char = ;code = 32
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char = g;code = 103
char = e;code = 101
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char = ;code = 32
char = b;code = 98
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char = t;code = 116
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char = w;code = 119
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char = u;code = 117
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char = a;code = 97
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char = i;code = 105
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char = e;code = 101
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char = C;code = 67
char = O;code = 79
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char = -;code = 45
char = 2;code = 50
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char = e;code = 101
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char = E;code = 69
char = C;code = 67
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char = c;code = 99
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char = h;code = 104
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char = C;code = 67
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char = c;code = 99
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char = <;code = 60
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char = C;code = 67
char = O;code = 79
char = N;code = 78
char = C;code = 67
char = L;code = 76
char = U;code = 85
char = S;code = 83
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = S;code = 83
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char = :;code = 58
char = ;code = 32
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char = a;code = 97
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char = C;code = 67
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char = a;code = 97
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char = -;code = 45
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char = p;code = 112
char = r;code = 114
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result sql = OBJECTIVES : Diet-derived flavonoids possess cancer chemopreventive properties in preclinical models. The knowledge of the pharmacology of most flavonoids is insufficient to warrant their advancement to clinical evaluation.

METHODS : Here the three flavonoids tricin from rice bran, apigenin from leafy vegetables, and quercetin from onions and apples, were compared in terms of their ability to modulate cyclooxygenase- (COX-) catalyzed prostaglandin E-2 (PGE-2) generation. Specifically their effects on the following parameters were studied: (1) COX enzyme activity, (2) COX-2 expression in human-derived colon cancer cells HCA-7, which express COX-2 constitutively, (3) phorbol ester-mediated COX-2 induction in human colon epithelial cells (HCEC), and (4) PGE-2 levels in cellular incubations.

RESULTS : Tricin and quercetin inhibited enzyme activity in purified COX-1 and -2 preparations with IC50 values of near 1 (tricin) and 5 microM (quercetin). Apigenin at up to 25 microM did not affect COX enzyme activity. Flavonoids were incubated with cells for 6 or 24 h and COX-2 protein expression and PGE-2 levels were assessed by Western blot and competitive immunoassay, respectively. None of the agents affected constitutive COX-2 expression in HCA-7 cells. Apigenin, but not tricin or quercetin, down-regulated inducible COX-2 expression in HCEC cells on 6 h incubation. All three flavonoids reduced cellular levels of PGE-2 in the supernatant of HCA-7 cells at both time points and of HCEC cells at 6 h.

CONCLUSIONS : The results demonstrate that these structurally similar flavonoids regulate COX-mediated PGE-2 production in different fashions. Their ability to attenuate prostanoid levels may contribute to their cancer chemopreventive efficacy.

Publication: Cancer Chemother. Pharmacol. 2006 Dec ;58(6)::816-25.
Publication Date: 2006 Dec
Study Author(s): Al-Fayez, Mohammad;Cai, Hong;Tunstall, Richard;Steward, William P;Gescher, Andreas J;
Institution: Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, LE2 7LX, Leicester, UK.
Shortcut link to this study:
OBJECTIVES : Diet-derived flavonoids possess cancer chemopreventive properties in preclinical models. The knowledge of the pharmacology of most flavonoids is insufficient to warrant their advancement to clinical evaluation.

METHODS : Here the three flavonoids tricin from rice bran, apigenin from leafy vegetables, and quercetin from onions and apples, were compared in terms of their ability to modulate cyclooxygenase- (COX-) catalyzed prostaglandin E-2 (PGE-2) generation. Specifically their effects on the following parameters were studied: (1) COX enzyme activity, (2) COX-2 expression in human-derived colon cancer cells HCA-7, which express COX-2 constitutively, (3) phorbol ester-mediated COX-2 induction in human colon epithelial cells (HCEC), and (4) PGE-2 levels in cellular incubations.

RESULTS : Tricin and quercetin inhibited enzyme activity in purified COX-1 and -2 preparations with IC50 values of near 1 (tricin) and 5 microM (quercetin). Apigenin at up to 25 microM did not affect COX enzyme activity. Flavonoids were incubated with cells for 6 or 24 h and COX-2 protein expression and PGE-2 levels were assessed by Western blot and competitive immunoassay, respectively. None of the agents affected constitutive COX-2 expression in HCA-7 cells. Apigenin, but not tricin or quercetin, down-regulated inducible COX-2 expression in HCEC cells on 6 h incubation. All three flavonoids reduced cellular levels of PGE-2 in the supernatant of HCA-7 cells at both time points and of HCEC cells at 6 h.

CONCLUSIONS : The results demonstrate that these structurally similar flavonoids regulate COX-mediated PGE-2 production in different fashions. Their ability to attenuate prostanoid levels may contribute to their cancer chemopreventive efficacy.
PMID: 16552572

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