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result sql = The pharmacology and regulation of T type calcium channels: new opportunities for unique therapeutics for cancer.
The pharmacology and regulation of T type calcium channels: new opportunities for unique therapeutics for cancer.
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char = o;code = 111
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char = u;code = 117
char = l;code = 108
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char = ;code = 32
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = r;code = 114
char = m;code = 109
char = a;code = 97
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char = o;code = 111
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char = l;code = 108
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char = T;code = 84
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char = N;code = 78
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char = l;code = 108
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char = a;code = 97
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char = l;code = 108
char = o;code = 111
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char = f;code = 102
char = ;code = 32
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char = t;code = 116
char = y;code = 121
char = p;code = 112
char = e;code = 101
char = ;code = 32
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char = a;code = 97
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char = ;code = 32
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = n;code = 110
char = e;code = 101
char = l;code = 108
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = J;code = 74
char = p;code = 112
char = n;code = 110
char = .;code = 46
char = ;code = 32
char = J;code = 74
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = ;code = 32
char = P;code = 80
char = h;code = 104
char = a;code = 97
char = r;code = 114
char = m;code = 109
char = a;code = 97
char = c;code = 99
char = o;code = 111
char = l;code = 108
char = :;code = 58
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char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
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char = 8;code = 56
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char = ;code = 32
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char = ;code = 32
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char = 3;code = 51
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char = 3;code = 51
char = 5;code = 53
char = 0;code = 48
char = .;code = 46
char = ];code = 93
char = ;;code = 59
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = y;code = 121
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = y;code = 121
char = ;code = 32
char = [;code = 91
char = E;code = 69
char = .;code = 46
char = ;code = 32
char = P;code = 80
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = z;code = 122
char = -;code = 45
char = R;code = 82
char = e;code = 101
char = y;code = 121
char = e;code = 101
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = M;code = 77
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = y;code = 121
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = l;code = 108
char = o;code = 111
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char = ;code = 32
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char = ;code = 32
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char = w;code = 119
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char = i;code = 105
char = v;code = 118
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = -;code = 45
char = t;code = 116
char = y;code = 121
char = p;code = 112
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = i;code = 105
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = n;code = 110
char = e;code = 101
char = l;code = 108
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = P;code = 80
char = h;code = 104
char = y;code = 121
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = l;code = 108
char = .;code = 46
char = ;code = 32
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = ;code = 32
char = R;code = 82
char = e;code = 101
char = v;code = 118
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = ;code = 32
char = 8;code = 56
char = 3;code = 51
char = ;code = 32
char = (;code = 40
char = 2;code = 50
char = 0;code = 48
char = 0;code = 48
char = 3;code = 51
char = );code = 41
char = ;code = 32
char = 1;code = 49
char = 1;code = 49
char = 7;code = 55
char = -;code = 45
char = 1;code = 49
char = 6;code = 54
char = 1;code = 49
char = .;code = 46
char = ];code = 93
char = );code = 41
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = -;code = 45
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = i;code = 105
char = e;code = 101
char = w;code = 119
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = u;code = 117
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = r;code = 114
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = o;code = 111
char = u;code = 117
char = r;code = 114
char = c;code = 99
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = T type calcium channels are implicated in a fascinating array of physiological and pathophysiological phenomena, as reviewed extensively in this issue of Cell Calcium. It is also evident from this timely collection of papers that knowledge about T channels is nascent. This creates the exciting potential to explore an uncharted territory for new insights into important physiological processes and associated diseases. Equally exciting and perhaps more important is the opportunity to exploit the developing understanding of T channels to design new therapeutic approaches to diseases that are now intractable to varying degrees. This review will focus on the controversy surrounding the proposed novel functions for and means of regulation of T type Ca2+ channels, particularly with regard to the potential role of pharmacologic modulation of T type Ca2+ channels in cytostatic cancer chemotherapy. In addition, we will concentrate on recent studies of the molecular pharmacology and physiology of T type channels, since these areas (molecular pharmacology [T.N. Heady, J.C. Gomora, T.L. Macdonald, E. Perez-Reyes, Molecular pharmacology of T-type Ca2+ channels, Jpn. J Pharmacol: 85 (2001) 339-350.]; physiology [E. Perez-Reyes, Molecular physiology of low-voltage-activated t-type calcium channels, Physiol.

Rev: 83 (2003) 117-161.]) have been very well-reviewed and the reader is referred to these authoritative sources.

Publication: Cell Calcium 2006 Aug ;40(2)::115-20.
Publication Date: 2006 Aug
Study Author(s): Gray, Lloyd S;Macdonald, Timothy L;
Institution: Department of Pathology, P.O. Box 800214, Charlottesville, VA 22911-0214, USA. [email protected]
Shortcut link to this study:
T type calcium channels are implicated in a fascinating array of physiological and pathophysiological phenomena, as reviewed extensively in this issue of Cell Calcium. It is also evident from this timely collection of papers that knowledge about T channels is nascent. This creates the exciting potential to explore an uncharted territory for new insights into important physiological processes and associated diseases. Equally exciting and perhaps more important is the opportunity to exploit the developing understanding of T channels to design new therapeutic approaches to diseases that are now intractable to varying degrees. This review will focus on the controversy surrounding the proposed novel functions for and means of regulation of T type Ca2+ channels, particularly with regard to the potential role of pharmacologic modulation of T type Ca2+ channels in cytostatic cancer chemotherapy. In addition, we will concentrate on recent studies of the molecular pharmacology and physiology of T type channels, since these areas (molecular pharmacology [T.N. Heady, J.C. Gomora, T.L. Macdonald, E. Perez-Reyes, Molecular pharmacology of T-type Ca2+ channels, Jpn. J Pharmacol: 85 (2001) 339-350.]; physiology [E. Perez-Reyes, Molecular physiology of low-voltage-activated t-type calcium channels, Physiol.

Rev: 83 (2003) 117-161.]) have been very well-reviewed and the reader is referred to these authoritative sources.
PMID: 16806465

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